Application of CUL7 in glioma diagnosis, treatment and prognosis

A technology for glioma and glioma cells, which is applied in the fields of biomedicine and molecular biology, and can solve problems such as unclear roles
CN110396544AActive Publication Date: 2019-11-01SHANDONG UNIV QILU HOSPITAL
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG UNIV QILU HOSPITAL
Publication Date
2019-11-01

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Abstract

The invention provides an application of CUL7 in glioma diagnosis, treatment and prognosis. Specifically, the invention proves that CUL7 expression is increased along with the increase of the malignancy degree of the glioma and is in negative correlation with a survival rate. The down regulation of the CUL7 inhibits the proliferation and the colony formation of glioma cells. Meanwhile, researchesdiscover that the CUL7 expression is increased along with the increase of the malignancy degree of the glioma and is in the negative correlation with the survival rate, the down regulation of the CUL7inhibits the proliferation and the colony formation of the glioma cells as well as inhibits the invasion and the migration of the glioma cells, meanwhile, the apoptosis of the glioma cells can be accelerated, and a glioma cell cycle is retarded. Meanwhile, the invention discovers that miR-3940 can target the CUL7 and further inhibit the proliferation, the invasion and the migration of the glioma,a reference is provided for the targeted treatment of the glioma, and therefore, the invention has a good practical application value.
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Description

technical field

[0001] The invention belongs to the technical fields of biomedicine and molecular biology, and in particular relates to the application of CUL7 in the diagnosis, treatment and prognosis of glioma. Background technique

[0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily to be regarded as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art.

[0003] Glioma, also known as glioma for short, is the most common primary central nervous system tumor, accounting for about 50% of all primary intracranial tumors. There are three types of gliomas according to their origin and the World Health Organization definition, including astrocytoma (astrocytoma grade I, II), grade III (anaplastic astrocytoma) and grade IV (GBM) . Due to the uncontrolled cell proliferati...

Claims

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