Application of CUL7 in glioma diagnosis, treatment and prognosis

A technology for glioma and glioma cells, which is applied in the fields of biomedicine and molecular biology, and can solve problems such as unclear roles

Active Publication Date: 2019-11-01
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cullin-7, CUL7 is a ubiquitinated ligase, the inventors found that its role in glioma has not yet been clarified

Method used

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  • Application of CUL7 in glioma diagnosis, treatment and prognosis
  • Application of CUL7 in glioma diagnosis, treatment and prognosis
  • Application of CUL7 in glioma diagnosis, treatment and prognosis

Examples

Experimental program
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Effect test

Embodiment 1

[0057] 1. Materials and methods

[0058] 1.1 Cox proportional hazards model and TCGA database analysis

[0059] Cox proportional hazards models were used to select genes associated with patient survival and build a predictive model for future predictions. Time to outcome was defined as overall survival in months and disease-free survival in months. Select N genes to build a Cox regression model; for each gene Gj (j=1, 2, ..., N), the following Cox model is established for the risk of life status or death at time t.

[0060]

[0061] in is the baseline risk function of gene Gj, and X1, X2, ..., XP are covariates. Adjusted covariates included race, age, sex, KPM (Karnofsky performance) score, tumor status, and history of neoadjuvant tumors. The transcript abundance of glial-associated CUL7 was mined from The Cancer Genome Atlas (TCGA, http: / / cancergenome.nih.gov). In all, 702 glioma cases including low-grade glioma (LGG, n=529) and glioblastoma (GBM, n=173) from the TCG...

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Abstract

The invention provides an application of CUL7 in glioma diagnosis, treatment and prognosis. Specifically, the invention proves that CUL7 expression is increased along with the increase of the malignancy degree of the glioma and is in negative correlation with a survival rate. The down regulation of the CUL7 inhibits the proliferation and the colony formation of glioma cells. Meanwhile, researchesdiscover that the CUL7 expression is increased along with the increase of the malignancy degree of the glioma and is in the negative correlation with the survival rate, the down regulation of the CUL7inhibits the proliferation and the colony formation of the glioma cells as well as inhibits the invasion and the migration of the glioma cells, meanwhile, the apoptosis of the glioma cells can be accelerated, and a glioma cell cycle is retarded. Meanwhile, the invention discovers that miR-3940 can target the CUL7 and further inhibit the proliferation, the invasion and the migration of the glioma,a reference is provided for the targeted treatment of the glioma, and therefore, the invention has a good practical application value.

Description

technical field [0001] The invention belongs to the technical fields of biomedicine and molecular biology, and in particular relates to the application of CUL7 in the diagnosis, treatment and prognosis of glioma. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily to be regarded as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Glioma, also known as glioma for short, is the most common primary central nervous system tumor, accounting for about 50% of all primary intracranial tumors. There are three types of gliomas according to their origin and the World Health Organization definition, including astrocytoma (astrocytoma grade I, II), grade III (anaplastic astrocytoma) and grade IV (GBM) . Due to the uncontrolled cell proliferati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/573G01N33/574A61K45/00A61P35/00
CPCC12Q1/6886G01N33/573G01N33/57407G01N33/57484A61K45/00A61P35/00C12Q2600/158C12Q2600/112G01N2333/9015
Inventor 李刚薛皓徐建业邓林郭钦栋张宇韩琳刘宏薛付忠
Owner SHANDONG UNIV QILU HOSPITAL
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