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Application of cul7 in diagnosis, treatment and prognosis of glioma

A technology for glioma and glioma cells, which is applied in the fields of biomedicine and molecular biology, and can solve problems such as unclear roles

Active Publication Date: 2021-12-24
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cullin-7, CUL7 is a ubiquitinated ligase, the inventors found that its role in glioma has not yet been clarified

Method used

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  • Application of cul7 in diagnosis, treatment and prognosis of glioma
  • Application of cul7 in diagnosis, treatment and prognosis of glioma
  • Application of cul7 in diagnosis, treatment and prognosis of glioma

Examples

Experimental program
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Effect test

Embodiment 1

[0057] 1. Materials and methods

[0058] 1.1 Cox proportional hazards model and TCGA database analysis

[0059] Cox proportional hazards models were used to select genes associated with patient survival and build a predictive model for future predictions. Time to outcome was defined as overall survival in months and disease-free survival in months. Select N genes to build a Cox regression model; for each gene Gj (j=1, 2, ..., N), the following Cox model is established for the risk of life status or death at time t.

[0060]

[0061] in is the baseline risk function of gene Gj, and X1, X2, ..., XP are covariates. Adjusted covariates included race, age, sex, KPM (Karnofsky performance) score, tumor status, and history of neoadjuvant tumors. The transcript abundance of glial-associated CUL7 was mined from The Cancer Genome Atlas (TCGA, http: / / cancergenome.nih.gov). In all, 702 glioma cases including low-grade glioma (LGG, n=529) and glioblastoma (GBM, n=173) from the TCG...

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Abstract

The present invention provides the application of CUL7 in the diagnosis, treatment and prognosis of glioma. Specifically, the present invention proves for the first time that the expression of CUL7 increases with the increase of the malignant degree of glioma, and is negatively correlated with the survival rate. Down-regulation of CUL7 inhibited the proliferation and colony formation of glioma cells. At the same time, it was found that the expression of CUL7 increased with the increase of the malignant degree of glioma, and was negatively correlated with the survival rate. The down-regulation of CUL7 inhibits the proliferation and colony formation of glioma cells, as well as the invasion and migration of glioma cells, and can promote the apoptosis of glioma cells and block the glioma cell cycle. At the same time, the present invention finds that miR-3940 can target CUL7, thereby inhibiting the proliferation, invasion and migration functions of glioma, and provides a reference for targeted therapy of glioma; thus, the present invention has good practical application value.

Description

technical field [0001] The invention belongs to the technical fields of biomedicine and molecular biology, and in particular relates to the application of CUL7 in the diagnosis, treatment and prognosis of glioma. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily to be regarded as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Glioma, also known as glioma for short, is the most common primary central nervous system tumor, accounting for about 50% of all primary intracranial tumors. There are three types of gliomas according to their origin and the World Health Organization definition, including astrocytoma (astrocytoma grade I, II), grade III (anaplastic astrocytoma) and grade IV (GBM) . Due to the uncontrolled cell proliferati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886G01N33/573G01N33/574A61K45/00A61P35/00
CPCC12Q1/6886G01N33/573G01N33/57407G01N33/57484A61K45/00A61P35/00C12Q2600/158C12Q2600/112G01N2333/9015
Inventor 薛皓李刚徐建业邓林郭钦栋张宇韩琳刘宏薛付忠
Owner SHANDONG UNIV QILU HOSPITAL
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