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Liquid handling system and a method for analysing a state of a tip

A liquid processing and state technology, applied in analytical materials, liquid/fluid solid measurement, liquid level indicator, etc., can solve the problem of unreliable detection of clogging of the tip, and achieve the effect of reliable detection

Pending Publication Date: 2019-11-15
SARTORIUS BIOHIT LIQUID HANDLING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Pressure measurement cannot reliably detect partial clogging of the tip while air can still flow through the clog

Method used

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  • Liquid handling system and a method for analysing a state of a tip
  • Liquid handling system and a method for analysing a state of a tip
  • Liquid handling system and a method for analysing a state of a tip

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Embodiment

[0130] Figure 19 The measurement system built into a hand-held mechanical pipette (Tacta model from Sartorius) is shown. The system is based on photometry. In this test system, no normalized detector was used. In all other respects, the system uses figure 2 The measurement geometry shown in . During the measurement, 1000-μl tips were used, and the dispensing volume was set at 1000 μl. The detector signal is recorded during liquid aspiration. Digital low-pass filtering is performed by averaging the instantaneous AD converter results obtained by polling from the measurement system. result in Figure 20 Shown in is a graph of measured signal intensity versus liquid volume in the tip. The results show that the system can reliably detect the presence of liquid in the tip and pick up the tip successfully.

[0131] It is to be understood that the disclosed embodiments of the invention are not limited to the specific structures, process steps or materials disclosed herein, b...

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Abstract

According to an example aspect of the present invention, there is provided a liquid handling system for dispensing a liquid sample from a tip. The system comprises a light source configured to projecta first beam of light via a first optical path that interacts with the tip or its contents, and further configured to direct a second beam of light via a second optical path that does not interact with the tip and its contents; a first detector configured to detect the first beam of light; a second detector configured to detect the second beam of light; an analysis unit configured to analyse a state of the tip on the basis of signals obtained from the first and second detectors; wherein the second detector is a normalization detector configured to measure intensity of the light source.

Description

technical field [0001] The present invention relates to liquid handling systems, and more particularly to optical and photometric methods for monitoring and analyzing the status of tips used in such systems. Background technique [0002] In handheld pipettes and automated liquid handling devices (liquid handling robots), precise pipetting requires reliable methods for detecting and monitoring the state of the tip that is aspirating the liquid. First, the tip needs to be immersed to a certain depth in the liquid to be aspirated. Then, a precise volume of liquid is aspirated while lowering the tip so that the lower end of the tip remains below the surface of the liquid. Finally, the tip is transferred over the holding container and some or all of the liquid is dispensed into the container. [0003] It is known to use pressure measurement or capacitive methods, eg for detecting liquid levels in pipette tips. These methods suffer from a number of disadvantages. For high visc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/10G01N21/31
CPCG01N35/1009G01N35/1016G01N21/31G01N2035/1025G01F23/292G01F23/2928G01N1/14G01N35/1011G01N2001/1418G01N2035/1062G01F23/2921
Inventor M.哈马莱宁P.维希宁S.福斯曼
Owner SARTORIUS BIOHIT LIQUID HANDLING
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