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An oligodeoxyribonucleotide for alleviating chronic visceral hyperalgesia in irritable bowel syndrome

A technology of deoxyribonucleotides and pain sensitivity, applied in the field of oligodeoxyribonucleotides, can solve the problems of limited effect on chronic pain

Active Publication Date: 2021-04-27
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs targeting the intestinal level, their main role is to solve the intestinal discomfort of IBS, and their effect on IBS chronic pain is relatively limited

Method used

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  • An oligodeoxyribonucleotide for alleviating chronic visceral hyperalgesia in irritable bowel syndrome
  • An oligodeoxyribonucleotide for alleviating chronic visceral hyperalgesia in irritable bowel syndrome
  • An oligodeoxyribonucleotide for alleviating chronic visceral hyperalgesia in irritable bowel syndrome

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Embodiment Construction

[0023] The present invention will be described in further detail below in conjunction with the accompanying drawings.

[0024] Test 1: Detection method of visceral pain in rats

[0025] The Colonic Dilation Threshold (CRD) assay was used to measure visceral pain behavior in rats by placing a flexible latex balloon attached to a Tygon tube through the anus under mild sedation (isoflurane inhalation anesthesia) in the rat (5 cm) was inserted into the rat's colon, approximately 7 cm from the anus, and the Tygon tube was tied in place at the tail. The rat was placed in a small hyaloid compartment, and the CRD threshold was measured. The recorded CRD threshold was the number of mmHg on the sphygmomanometer when the pressure was steadily increased by the sphygmomanometer to make the rat's abdomen have a significant contraction response. To reduce the possible damage caused by repeated stimulation of colonic distension, the rats were acclimated to the environment for 30 minutes befo...

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Abstract

The invention discloses an oligodeoxyribonucleotide for alleviating chronic visceral hyperalgesia in irritable bowel syndrome. The oligodeoxyribonucleotide contains a transcription factor GATA1 binding site, its 5' end is added with a FAM fluorescent group, the second base is modified with a methoxy group to enhance its stability in vivo, and the 3' end is passed through a cholesterol Modified so that it can cross the cell membrane and the blood-brain barrier, the present invention can effectively alleviate the chronic visceral hyperalgesia in adult rats induced by neonatal colonic inflammatory stimulation (NCI), and is expected to be used for clinical treatment of irritable bowel syndrome ( IBS) chronic abdominal pain. And the medicine of the present invention has no side effects on the motor function of NCI rats; in addition, the present invention also has a certain improvement effect on hindlimb mechanical hyperalgesia caused by diabetic neuropathy and inflammatory pain caused by CFA.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an oligodeoxyribonucleotide for relieving chronic visceral hyperalgesia of irritable bowel syndrome. Background technique [0002] Irritable bowel syndrome (IBS) is a group of persistent or intermittent episodes characterized by abdominal pain, bloating, changes in bowel habits and / or stool characteristics, and lack of gastrointestinal structural and biochemical abnormalities in the gut Dysfunction disease. Persistent or frequent abdominal pain is reported by 75% of IBS patients, and unlike general chronic pain, IBS pain is often associated with changes in bowel movements (diarrhea, constipation, or both). New drugs for IBS developed in the past decade have focused on the gut level, such as anticholinergic drugs taken before meals can reduce abdominal pain for a short time after meals. In addition, centrally targeted drugs such as antidepressants are also used to treat chro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H21/04A61K47/55A61P29/00A61P1/00
CPCA61K47/554A61P1/00A61P29/00C07H21/04
Inventor 徐广银张平安许雪杜婉洁许宇成张冰玉
Owner SUZHOU UNIV
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