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Oligodeoxyribonucleotide for relieving chronic visceral pain sensitivity of irritable bowel syndrome

A technology of deoxyribonucleotides and pain sensitivity, applied in the field of oligodeoxyribonucleotides, can solve the problems of limited effect on chronic pain, and achieve the effect of alleviating chronic visceral hyperalgesia and improving inflammatory pain

Active Publication Date: 2020-04-07
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs targeting the intestinal level, their main role is to solve the intestinal discomfort of IBS, and their effect on IBS chronic pain is relatively limited

Method used

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  • Oligodeoxyribonucleotide for relieving chronic visceral pain sensitivity of irritable bowel syndrome
  • Oligodeoxyribonucleotide for relieving chronic visceral pain sensitivity of irritable bowel syndrome
  • Oligodeoxyribonucleotide for relieving chronic visceral pain sensitivity of irritable bowel syndrome

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Embodiment Construction

[0023] The present invention will be described in further detail below in conjunction with the accompanying drawings.

[0024] Experiment 1: Detection method of visceral pain in rats

[0025] The colon dilatation threshold (CRD) assay was used to measure visceral pain behavior in rats by passing a flexible latex balloon attached to a Tygon tube through the anus while the rat was mildly sedated (isoflurane inhalation anesthesia) (5 cm) into the colon of the rat, approximately 7 cm from the anus, and a Tygon tube tied to the tail to hold it in place. Put the rats in a small hyaluronic compartment, and measure the CRD threshold. The recorded CRD threshold is the millimeter Hg of the sphygmomanometer when the pressure is steadily increased by the sphygmomanometer so that the rat abdomen has a significant contraction response. To reduce the possible damage caused by repetitive expansion stimulation of the colon, let the rats acclimate to the environment for 30 minutes before measu...

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Abstract

The invention discloses oligodeoxyribonucleotide for relieving chronic visceral pain sensitivity of irritable bowel syndrome. The oligodeoxyribonucleotide comprises a segment of transcription factor GATA1 binding site, wherein an FAM fluorophore is added at the 5'-end of the oligodeoxyribonucleotide; the second basic group in the sequence structure of the oligodeoxyribonucleotide is modified by amethoxy group to enhance the stability of the oligodeoxyribonucleotide in vivo; and the 3'-end of the oligodeoxyribonucleotide is modified by cholesterol, so the oligodeoxyribonucleotide can penetratethrough cell membranes and blood-brain barriers. The oligodeoxyribonucleotide provided by the invention can effectively relieve an adult-rat chronic visceral pain sensitive reaction induced by nascent colitis stimulation (NCI), and is expected to be used for clinically treating the chronic abdominal pain of the irritable bowel syndrome (IBS). Meanwhile, a medicine provided by the invention is free of side effects on the movement function of NCI rats; in addition, the oligodeoxyribonucleotide provided by the invention has a certain effect of improving posterior limb mechanical pain sensitivitycaused by diabetic neuropathy and inflammatory pain caused by CFA.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an oligodeoxyribonucleotide for alleviating chronic visceral hyperalgesia in irritable bowel syndrome. Background technique [0002] Irritable bowel syndrome (IBS) is a group of persistent or intermittent episodes characterized by abdominal pain, bloating, changes in bowel habits and / or stool characteristics, and the lack of gastrointestinal structural and biochemical abnormalities Dysfunctional diseases. Seventy-five percent of IBS patients report persistent or frequent abdominal pain, and unlike general chronic pain, IBS pain is often associated with changes in bowel movements (diarrhea, constipation, or both). Newer drugs for IBS developed in the past decade have largely focused on the gut level, as anticholinergic drugs taken before meals can reduce abdominal pain for a short time after meals. In addition, centrally targeted drugs such as antidepressants are also used t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H21/04A61K47/55A61P29/00A61P1/00
CPCA61K47/554A61P1/00A61P29/00C07H21/04
Inventor 徐广银张平安许雪杜婉洁许宇成张冰玉
Owner SUZHOU UNIV
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