Application of gold compounds in the preparation of antibacterial agents

An antibacterial agent and compound technology, which is applied to the application field of gold compounds in the preparation of antibacterial agents, can solve the problems of slow progress in the development of antibiotics, and achieve the effect of good antibacterial effect.

Active Publication Date: 2021-04-13
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The powerful ability of these bacteria to acquire drug resistance and clone transmission has caused multi-drug resistance, pan-drug resistance and even full drug resistance strains to be prevalent worldwide. The situation of drug resistance is very severe, but the development of corresponding antibiotics is still progressing. slow

Method used

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  • Application of gold compounds in the preparation of antibacterial agents
  • Application of gold compounds in the preparation of antibacterial agents
  • Application of gold compounds in the preparation of antibacterial agents

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]

[0029] Select 4 drug-resistant Acinetobacter baumannii bacterial strains, cultivate overnight under low-nutrition conditions, select the minimum inhibitory concentration (MIC) of 4 strains of Acinetobacter baumannii after selecting compound 1-6 and comparative example 1 configuration and minimum bactericidal concentration (MBC). Each experiment consisted of three technical replicates and three biological replicates. (Among them, A.baumannii 53264 and A.baumannii ACICU are common drug-resistant strains of Acinetobacter baumannii, and A.baumannii R-1008 and A.baumannii17009 are from Shenzhen Third People's Hospital)

[0030] The specific detection method is as follows:

[0031] ①Take out the frozen bacterial liquid from the -80°C refrigerator, dip a small amount of bacterial liquid with an inoculation needle and streak on the LB agar plate according to the conventional method, and culture it upside down at 37°C overnight.

[0032] ② Pick a single colony grown on an...

Embodiment 2

[0043]

[0044] For compound 1 with better antibacterial effect, other drug-resistant strains of Acinetobacter baumannii were selected for detection of minimum inhibitory concentration and minimum bactericidal concentration. Three People's Hospital), detection method with reference to embodiment 1, detection result is as shown in the following table:

[0045] Table 2. Antibacterial effect on 10 strains of drug-resistant Acinetobacter baumannii

[0046]

[0047]It can be seen from the above results that compound 1 exhibited excellent antibacterial effects against various drug-resistant Acinetobacter baumannii. Compared with the existing common disinfectants, it can effectively kill drug-resistant Acinetobacter baumannii at a very low concentration. At the same time, there is no significant difference in the antibacterial effect of the compound on different strains of Acinetobacter baumannii, and the overall antibacterial effect on Acinetobacter baumannii can be reflected...

Embodiment 3

[0049]

[0050] The highly resistant A.baumannii 53264 and A.baumannii ACICU were selected as the research objects, and the bactericidal curve of compound 1 was drawn. The specific experimental steps are as follows:

[0051] ①Take out the frozen bacterial liquid from the -80°C refrigerator, dip a small amount of bacterial liquid with an inoculation needle and streak on the LB agar plate according to the conventional method, and culture it upside down at 37°C overnight.

[0052] ② Pick a single colony grown on an LB agar plate, inoculate it into ABTGC or ABTGC liquid medium containing 10% TSB, and culture it overnight on a shaker at 37°C and 200rpm for 18 hours, adjust the OD value of the bacterial solution to 1, and use ABTGC or ABTGC liquid medium containing 10% TSB was diluted to a bacterial concentration of approximately 1×10 6 CFU / mL.

[0053] ③The concentrations of the prepared compounds are 0, 1×MIC, 2×MIC and 4×MIC, respectively, take 5mL of the prepared compound in...

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Abstract

The invention discloses the application of a class of compounds or pharmaceutically acceptable salts thereof in the preparation of antibacterial agents. The compounds have a structural formula such as formula (I). The compound provided by the invention can quickly and effectively kill germs at a lower concentration, so as to achieve better antibacterial effect.

Description

technical field [0001] The invention relates to the technical field of antibacterial agents, in particular to the application of a class of gold compounds in the preparation of antibacterial agents. Background technique [0002] The World Health Organization issued a report stating that the current development of new antibiotics is seriously insufficient to combat the growing threat of antimicrobial resistance. Also identified in the report are 12 priority pathogens whose microbes are increasingly resistant to existing antibiotics and in which new therapeutics are urgently needed. These 12 key pathogens include six drug-resistant bacteria ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and some specific bacteria of the genus Enterobacter spp. The six major drug-resistant bacteria are widely distributed in the natural environment and are important pathogenic bacteria that cause nosocomial infections...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/66A61P31/04
CPCA61K31/66A61P31/04Y02A50/30
Inventor 杨亮刘玉梅刘洋韩舒虹刘晓璇
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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