The invention discloses a compound cefixime nano-emulsion antibacterial drug, which is formed by the following raw materials in mass percent: 23.0%-38.5% of surfactant, 3.0%-18.0% of oil, 0.2%-6.0% of cefixime, 0.05%-1.5% of probenecid and the balance of distilled water, wherein the sum of the mass percents of the raw materials is 100%. The compound cefixime nano-emulsion antibacterial drug is mainly used for treating bacterial infectious diseases, including respiratory tract diseases, urinary tract diseases, genital tract infections, otitis media, nasal sinusitis and scarlet fever, which are caused by streptococcus, pneumococcus, neisseria gonorrhoeae, bacillus coli, proteus and haemophilus influenza and the like. The compound cefixime nano-emulsion antibacterial drug has the advantages that: the nano-emulsion preparation is clear and transparent liquid and is good in stability, rapid in absorption and targeted in drug release, the problem of poor solubility of the nano-emulsion preparation in water is solved, the metabolic time of the nano-emulsion preparation in vivo is retarded, the consumption of adjuvants is reduced, and the production cost is lowered, so that the compound cefixime nano-emulsion antibacterial drug has broad market prospects in the medicine field.