Compound cefixime nano-emulsion antibacterial drug and preparation method thereof

Abstract

The invention discloses a compound cefixime nano-emulsion antibacterial drug, which is formed by the following raw materials in mass percent: 23.0%-38.5% of surfactant, 3.0%-18.0% of oil, 0.2%-6.0% of cefixime, 0.05%-1.5% of probenecid and the balance of distilled water, wherein the sum of the mass percents of the raw materials is 100%. The compound cefixime nano-emulsion antibacterial drug is mainly used for treating bacterial infectious diseases, including respiratory tract diseases, urinary tract diseases, genital tract infections, otitis media, nasal sinusitis and scarlet fever, which are caused by streptococcus, pneumococcus, neisseria gonorrhoeae, bacillus coli, proteus and haemophilus influenza and the like. The compound cefixime nano-emulsion antibacterial drug has the advantages that: the nano-emulsion preparation is clear and transparent liquid and is good in stability, rapid in absorption and targeted in drug release, the problem of poor solubility of the nano-emulsion preparation in water is solved, the metabolic time of the nano-emulsion preparation in vivo is retarded, the consumption of adjuvants is reduced, and the production cost is lowered, so that the compound cefixime nano-emulsion antibacterial drug has broad market prospects in the medicine field.

Description

technical field The invention belongs to the field of medicine and relates to a new dosage form of antibacterial drugs, in particular to a compound cefixime nanoemulsion antibacterial drug and a preparation method thereof. Background technique Cefixime is the third generation of oral cephalosporin antibiotics, also known as cefixime cephalosporins, Shifusu, Shifusu, by binding to one or more penicillin-binding proteins (PBPs), inhibit bacterial The cell wall of dividing cells is synthesized to play a bactericidal effect. It is clinically used to treat diseases caused by Streptococcus (except Enterococcus), Streptococcus pneumoniae, Neisseria gonorrhoeae, Escherichia coli, Branhamella catarrhalis, Serratia, Citrobacter, Enterobacter cloacae, Enterobacter aerogenes, Bacterial infectious diseases caused by Haemophilus influenzae, Klebsiella, Serratia, Proteus and influenza bacillus, suitable for bronchitis, pneumonia, pyelonephritis, cystitis, urethritis, cholecystitis, bile d...

AI Technical Summary

Problems solved by technology

At present, there are mainly cefixime capsules, tablets, granules and dry suspensions on the market, but the current problem is that cefixime is insoluble in water, oral absorption is slow, the effect is poor, and the bioavailability is extremely low

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