Beta-defensin 15 of specific antibacterial peptides of rat epididymis and application thereof

A use, mouse technology, applied in the direction of antibacterial drugs, antifungal agents, antibodies, etc., can solve problems such as less β-defensins

Active Publication Date: 2011-09-28
苏州中科细胞转化研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, in addition to immune defense, they may also play a role in maintaining normal reproductive processes, such as participating in the maturation and protection of sperm, and it has been proven that there are very few β-defensins involved in this process

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  • Beta-defensin 15 of specific antibacterial peptides of rat epididymis and application thereof
  • Beta-defensin 15 of specific antibacterial peptides of rat epididymis and application thereof
  • Beta-defensin 15 of specific antibacterial peptides of rat epididymis and application thereof

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Abstract

The invention relates to beta-defensin 15 of specific antibacterial peptides of rat epididymis and application thereof, in particular to Defb15 genes of rats or orthologous genes thereof or application of amino acid sequences of the Defb15 genes or the orthologous genes thereof in the preparation of medicines for regulating and controlling male fertility, the development of male contraceptive medicines and the preparation of medicines for diagnosing and treating male infertility and resisting genital tract infection. The invention also relates to a medicinal composition containing the genes or the amino acid sequences.

Description

technical field This application relates to epididymis-specific antimicrobial peptide β-defensin 15 (defensin) and its application. Background technique The epididymis is a highly coiled tube that connects the testis and the vas deferens. It is the place for sperm maturation, protection, transportation and storage, and plays an important role in the reproduction of male mammals. Morphologically, the epididymis is roughly divided into four segments: Initial segment, Caput, Corpus, and Cauda. Sperm released from the seminiferous tubules of the testis are functionally immature and need to undergo a series of complex structural and functional changes in the epididymis to acquire motility and potential fertilization ability to reach maturity[1-4]. It is derived from the interaction of spermatozoa with the luminal fluid of the epididymis. Epididymis intima epithelial cells can secrete a variety of proteins, some of which can be incorporated or bound to the surface of sperm membr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K48/00A61K39/395A61K31/713A61P15/16A61P15/08A61P15/00A61P31/04A61P31/10
Inventor 张永莲赵越刁华
Owner 苏州中科细胞转化研究院
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