The invention provides a drug for mainly treating gynecologic inflammation such as colpitis, urethritis, pelvic inflammation, endometritis, adnexitis, cervix erosion, and the like, and a preparation method thereof. The drug is composed of the following 16 traditional Chinese herbals: sargentg loryvine, dandelion, sappan wood, prunella vulgaris, coix seed, red sage root, peach seed, eupatorium, corydalis tuber, ligusticum wallichii, frankincense, myrrh, dried orange peel, pericarpium citri reticulatae viride, lindera aggregate, and spina gleditsiae. The provided drug is developed by combining the traditional formula and the modern pharmacopeia, is a novel product obtained by upgrading the traditional decoction, and has the functions of clearing heat, removing toxicity, activating blood circulation, freeing the collaterals, eliminating swelling, relieving pains, invigorating the spleen, removing dampness, regulating qi, and resolving stasis. Through researches and clinical observation by several generations of people, people find that the drug has a definite curative effect on gynecologic inflammation such as colpitis, urethritis, pelvic inflammation, endometritis, adnexitis, cervix erosion, and the like.