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External contraceptive capable of preventing and curing genital tract infection

A technology for reproductive tract infection and contraceptives, which is applied in the directions of medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, and can solve the problem of the lack of breakthroughs in the combined mechanical/chemical barrier method, the inconvenience of condoms, and the bacterial flora of the reproductive tract. Injury and other problems, to achieve good synergistic efficacy of spermicidal contraception, prevention and treatment of reproductive tract inflammation, and reduce side effects

Active Publication Date: 2014-12-10
TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The barrier contraceptive method has a good preventive effect on STI, but because of the inconvenience, tearing and affecting sexual pleasure in the use of condoms, most of the cases are intermittent use, which greatly reduces the preventive effect
The female condom may have harmful effects on normal reproductive tract flora, and the cost is higher than that of the male condom, especially in developing countries, the acceptability is low
The effect of topical spermicide and chemical agents with disinfectant effect on the prevention of sexually transmitted infection (STI) is still under study, and the use of disinfectants is limited due to the irritation to the local mucosa and the destruction of the vaginal environment. Combined mechanical / chemical The barrier method has not made breakthrough progress

Method used

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  • External contraceptive capable of preventing and curing genital tract infection
  • External contraceptive capable of preventing and curing genital tract infection
  • External contraceptive capable of preventing and curing genital tract infection

Examples

Experimental program
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Embodiment 1

[0034] Composition: Phellodendron 10g, Ginkgo 10g, Nightshade 30g, Dandelion 15g, Patrinia 30g, Moss bark 10g, Smilax smilax 15g, mint 10g, borneol 0.3g, Moutan bark 10g.

[0035] Preparation:

[0036] 1) Cortex Phellodendri is heated and refluxed twice with 70% ethanol with a mass fraction of 6 times its weight, each time for 1 hour, the extracts are combined, filtered, and the filtrate is used for subsequent use;

[0037] 2) Carry out steam distillation of Moutan bark, collect the distillate, about 30ml, and set aside;

[0038] 3) Peppermint is subjected to steam distillation, and the distillate is collected for subsequent use;

[0039] 4) Decoct the residues of ginkgo, black nightshade, dandelion, Patrinia, white moss bark, Smilax cocos, mint, Phellodendron cortex and Moutan bark with water for two times, the amount of water added is 8 to 10 times the total weight of the drug, 1.5 times each time hours, combine the decoctions, filter, concentrate the filtrate to a relativ...

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Abstract

The invention discloses an external contraceptive capable of preventing and curing genital tract infection and a preparation method of the external contraceptive. The external contraceptive is prepared from the following raw materials in parts by weight: 10-40 parts of cortex phellodendri, 10-40 parts of ginkgo, 30-120 parts of black nightshade, 20-60 parts of dandelion, 3-120 parts of dahurian patrinia herb, 10-40 parts of dittany bark, 30-120 parts of glabrous greenbrier rhizome, 10-25 parts of mentha haplocalyx, 1.0-2.5 parts of borneol and 10-40 parts of tree peony bark. The external contraceptive not only can effectively prevent and cure genital tract infection, but also has the efficacy of killing sperms through external use. The external contraceptive has a vagina protection effect and moreover has the effects of preventing and curing genital tract inflammation and lubrication. The external contraceptive has a killing or restraining effect on common vagina pathogens and part of sexually transmitted infection pathogens, and has little influence on lactic acid bacteria. Compared with a conventional spermicide product for vaginal use, the external contraceptive causes fewer adverse reactions such as local stimulation.

Description

technical field [0001] The invention relates to an external contraceptive, in particular to an external contraceptive capable of preventing and treating lower reproductive tract infection. Background technique [0002] Female lower genital tract infection (Genital Tract Infection GTI) disease is a clinical common disease, frequently-occurring disease. Sexually Transmitted Infection (STI) refers to diseases transmitted through sexual contact (formerly known as Sexually Transmitted Diseases, STDs). [0003] Since the 1980s, the floating population has increased, sexual concepts have changed, and unsafe sex behaviors have increased. The increase of reproductive tract infection (Reproductive Tract Infection RTI) and STI in my country has spread from the coast to the inland, and developed from the city to the countryside. For example, acquired immunodeficiency syndrome (Acquired immunodeficiency syndrome, AIDS) has spread from high-risk groups to low-risk groups, and the situat...

Claims

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Application Information

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IPC IPC(8): A61K36/90A61K36/896A61P15/18A61P15/00A61K31/045
Inventor 陈琢方建国徐丽君
Owner TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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