21 results about "Gold Compounds" patented technology

Provided herein are methods composition for treating lung cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of an imidazolate gold compound according to Formula I, or a pharmaceutically acceptable salt, racemate, or enantiomer thereof, wherein Formula I is a gold complex having a structure Au(L)(L′)n, wherein: n is an integer from 1 to 3; L is an imidazolyl-based N-heterocyclic carbene (NHC) ligand; and each L′ is independently selected from an imidazolyl-based NHC ligand, a triaryl phosphine, or a halide.

The objective is to provide an aqueous solution of gold(I) compounds that can be used as a gold source for gold plating solutions without causing precipitation over a wide pH range and with long-term oxidation stability. [Solution] An aqueous solution of a gold(I) compound having a structure represented by the following general formula (1), wherein the cyanide concentration is 500 mg / L or less, the sulfite ion concentration is 1000 ppm by mass or less, and the halogen ion concentration is 1000 mg / L or less. RS - -Au-S-(CH2) n -SO3 - ...(1) (In formula (1), R is an organic group having at least one group selected from the group consisting of a sulfonic acid group, a carboxyl group, and an amino group at its terminal or side chain, and n is an integer from 3 to 10.)

The application discloses a kind of integrated circuit chip package lead frame's electroless gold plating solution and its gold plating method, it is related to integrated circuit chip packaging field.Therein, electroless gold plating solution is following concentration component aqueous solution: water-soluble gold compound, with Au, concentration is 1-1.5g / L;Sodium hypophosphite 10~20g / L;Malic acid 15~20g / L;Citric acid 15~20g / L;N,N'-bis (2-hydroxyethyl) ethylenediamine 10~15g / L;Triammonium citrate 15~20g / L;EDTA-2Na 5~10g / L;5,5'-dimethyl hydantoin 5~10g / L;Metal ion catalyst, with metal ion, concentration is 2~3ppm;Mercaptoimidazole 0.01~0.015g / L;Hexamethylenetetramine 5~10g / L.The electroless gold plating solution in the application can consider stability, high deposition rate and plating layer deposition uniformity.

The present invention provides a method for producing a catalyst that makes it possible to produce vinyl acetate with improved selectivity while ensuring high catalytic activity. Provided is a method for producing a catalyst that is for vinyl acetate production and that contains a carrier, palladium, gold, copper, and an acetate, said method comprising: step 1, which is for impregnating an alkaline solution into the carrier; step 2, which is for causing a solution containing a compound that includes palladium, a compound that includes gold, and a compound that includes copper to come into contact with and impregnate the carrier; step 5, which is for performing a liquid phase reduction treatment in the range of 0-15°C; and step 6, which is for causing the carrier to support the acetate.

The invention relates to a catalyst for preparing vinyl acetate and a preparation method and application thereof, and the preparation method comprises the following steps: mixing and kneading superfine silica powder, superfine diatomite, silica sol and a boron compound according to the weight ratio of 100: (5-20): (10-60): (0.1-1), drying, molding, and roasting at 150-650 DEG C for 1-6 hours to prepare a boron-doped composite SiO2 carrier; according to the molar ratio of Pd / (Au + Pd) being 0.76-0.93 and the mass of the carrier being 0.5%-1%, carrying out isovolumetric rolling impregnation by using a palladium and gold compound solution, and then drying; treating for 0.5-30 hours by using an alkaline solution, drying, reducing for 1-6 hours at the temperature of 300-650 DEG C in a nitrogen-hydrogen atmosphere, washing with water until no chlorine exists, and drying; mixing copper acetate and rhenium oxide with 0.5%-3% of aluminum phosphate according to the molar ratio of Cu / (Re + Cu) of 0.93-0.97 and 0.3%-1% to prepare dilute sol, dipping, coating and drying; dipping in a potassium acetate solution according to the proportion of 0.2%-7.5%, and carrying out negative pressure heat treatment at 60-200 DEG C for 1-6 hours; the obtained high-stability long-life catalyst is high in strength and few in by-products.

The invention discloses a preparation method of mesoporous plasmon nanoparticles and application of the mesoporous plasmon nanoparticles in an optical excitation gas sensor. The preparation method of the nanoparticles comprises the following steps: dissolving a gold-containing compound in water, adding a reducing agent, and heating for reaction to obtain a colloidal gold solution; adding water and a second reducing agent, and stirring to obtain a gold nanoparticle aqueous dispersion; adding an organic solvent, a surfactant and a pore expanding agent, emulsifying, adding a dopamine precursor, adjusting the pH to be alkaline to form a mesoporous polydopamine shell layer, and washing and drying; and finally, dipping in a tin-containing compound solution, and carrying out calcination treatment. The prepared mesoporous plasmon nanoparticles can be applied to preparation of optical excitation gas sensors. The sensor has high sensitivity and high selectivity response to NO2 gas, can stably work at room temperature, and shows excellent response performance to the NO2 gas concentration range of 0.2-10 ppm.

The invention relates to the technical field of preparation of anti-cancer drugs, in particular to a Schiff base gold (III) compound and a preparation method and application thereof.The series of symmetric or asymmetric Schiff base gold (III) compounds are synthesized on the basis of the bioisostere principle in combination with a Schiff base ligand, the cyclohexanediamine structure and the NNOO coordination mode of oxaliplatin are reserved, platinum (II) is replaced with gold (III), and the Schiff base gold (III) compound is synthesized. Meanwhile, the invention relates to application of the Schiff base gold (III) compound in preparation of anti-hepatoma drugs, the defects that oxaliplatin is strong in side effect and the like are overcome, in-vivo and in-vitro experiment results of the Schiff base gold (III) compound provided by the invention show that the compounds Au3 and Au7 are remarkable in anti-hepatoma activity and can target thioredoxin reductase (TrxR) and mitochondrial DNA (mtDNA) at the same time, and the Schiff base gold (III) compound can be used for preparing anti-hepatoma drugs. The further mechanism research shows that the compound can promote the generation of reactive oxygen species (ROS) to cause endoplasmic reticulum stress (ERS) and mitochondrial injury and finally induce pyroptosis and immunogenic cell death, and has great application potential.

The application discloses synthesis of a novel Schiff base gold (III) compound and antibacterial application thereof, and belongs to the technical field of medicine preparation; gold sodium aurothiomalate has significant antibacterial activity, but the Au-S bond thereof is easily broken by intracellular reducing thiol, and the gold sodium aurothiomalate is metabolized before reaching a target point to produce toxic side effects; based on the gold sodium aurothiomalate, developing a gold compound with stronger stability is one of strategies for overcoming drug-resistant bacteria; the Schiff base itself has antibacterial activity, and after being combined with gold (III) ions, the Schiff base can stabilize gold atoms and improve the activity of the gold atoms; in vitro antibacterial activity shows that Au6 and Au13 have significant antibacterial advantages on carbapenem and polymyxin-resistant Klebsiella pneumoniae, the minimum inhibitory concentration (MIC) is 10 micromoles, and the antibacterial activity is at least 16 times higher than that of the gold sodium aurothiomalate; in vivo antibacterial activity experiments prove that Au6 and Au13 can reduce mouse skin infection and promote wound healing, and can prolong the survival time of abdominal infection mice, and have important practical application value.

Presented is a method for making a catalyst that can produce vinyl acetate with very high selectivity while ensuring high catalyst activity. A method for preparing a catalyst for the production of vinyl acetate comprising a carrier, copper, palladium, gold and acetate, the method comprising the following steps: Step 1) a step for impregnating the carrier with an alkaline solution; Step 2) a step for impregnating the carrier with a solution containing a copper-containing compound, a palladium-containing compound and a gold-containing compound; Step 3) a step for carrying out a reduction operation; and Step 4) a step for causing the carrier to carry acetate.

The application relates to the technical field of metal organic complexes, in particular to a chiral Au 16 Metal complex and preparation method and application thereof. By using a specific chiral 1,4-di (dithiocarbamate) -2-methyl piperazine potassium salt ligand, a specific chiral Au 16 Metal complex, 16 Au atoms in the structure of the metal complex form an Au 16 Macrocycle, 16 gold atoms form a polynuclear gold compound, and the chiral Au 16 Drug activity of the metal complex on cancer cells. In in-vitro cell experiments, the chiral Au 16 The metal complex has good in-vitro anticancer activity in different cancer cell lines. Meanwhile, due to the Au-Au bonding, a macrocycle structure is formed, and the chiral Au 16 Cytotoxicity of the metal complex on normal cells.

The present invention discloses phenanthroline-functionalized nitrogen heterocyclic carbene homonuclear and heteronuclear silver-gold compounds, methods, and applications. A binuclear N-heterocyclic carbene (NHC) silver complex (NHC-Ag2) and a heteronuclear NHC silver / gold bimetallic complex (NHC-Ag / Au) are synthesized using a phenanthroline-functionalized imidazole salt (HLPF6) ligand. NHC ligands have strong coordination ability and are easy to modify structurally, making them suitable for structural optimization of metal drugs. Heterocyclic functionalized NHC ligands are easy to construct multinuclear metal compounds, which can enhance the drug activity of metal drugs against cancer cells. The synthesized nitrogen heterocyclic carbene binuclear silver and heteronuclear silver / gold compounds have good in vitro anticancer activity in different cancer cell lines. Mechanism studies in colon cancer LoVo cells show that they cause increased intracellular reactive oxygen species and mitochondrial dysfunction, inducing cell necrosis.

The invention belongs to the technical field of fertilizers, and particularly relates to a multi-enzyme gold biological organic enzyme agricultural fertilizer. 8-12 parts of a mesoporous multienzyme gold compound, 10-15 parts of a temperature-sensitive enzyme nutrient compound, 3-5 parts of growth-promoting rhizobacteria microspheres, 62-76 parts of an organic carrier, 2-4 parts of a trace element additive and 1-2 parts of a pH buffer agent; wherein the mesoporous multienzyme gold compound is formed by compounding a functionalized silicon carbon carrier and a multienzyme gold compound according to a mass ratio of 1: 2; the temperature-sensitive enzyme nutrient compound is formed by compounding poly N-isopropylacrylamide, a biological organic enzyme and a slow-release nutrient according to a mass ratio of 2: 1: 3; the growth-promoting rhizobacteria microspheres are microspheres of a double-layer structure, and the growth-promoting rhizobacteria microspheres comprise the following components in parts by weight: 45-55 parts of an inner-layer bacterial strain protection layer and 45-55 parts of an outer-layer bacteriostatic protection layer.

The invention belongs to the field of organic synthesis, and particularly relates to an N-heterocyclic carbene gold compound and a preparation method and application thereof.The preparation method comprises the steps that an intermediate II is prepared, and after the intermediate II, a compound X and alkali are mixed and dissolved, an esterification reaction is conducted to generate an intermediate III; and fully mixing the intermediate III with an inorganic silver reagent, then adding an organic gold reagent and potassium salt, carrying out gold ion coordination reaction, and after the reaction is completed, carrying out post-treatment, separation and purification to obtain the product. The N-heterocyclic carbene gold compound disclosed by the invention has an anti-tumor immune effect and an anti-ferroptosis effect, and has a liver cancer specific targeting capability.

The invention belongs to the technical field of N-heterocyclic carbene gold compounds, relates to a double-pharmacophore N-heterocyclic carbene gold compound 1-14 and application thereof, and discloses a specific structure of the double-pharmacophore N-heterocyclic carbene gold compound 1-14, and the double-pharmacophore N-heterocyclic carbene gold compound 1-14 is prepared by replacing a triethyl phosphine group in gold nofen with NHC, and then adding a compound 1-14 and a compound 2-14, so that the double-pharmacophore N-heterocyclic carbene gold compound 1-14 is obtained. A traditional Chinese medicine micromolecule ferulic acid Fa is introduced for synthesis; the invention discloses application of double-pharmacophore N-heterocyclic carbene gold compounds 1-14 in preparation of anti-hepatoma drugs. The double-pharmacophore N-heterocyclic carbene gold compound Fa-Au has anti-proliferative activity on liver cancer cells HepG2 and Hepa 1-6, obviously inhibits the growth of tumors in a mouse, and improves the tumor immune microenvironment of the mouse at the same time; the N-heterocyclic carbene gold-ferulic acid compound has the advantages of reliable curative effect, no toxic or side effect, simple preparation, low price and the like.

A method for producing a catalyst for vinyl acetate production comprising a carrier, copper, palladium, gold, and an acetic acid salt, the method comprising, in the following order, step 1, in which an alkali solution is infiltrated into the carrier, step 2, in which the carrier is brought into contact and impregnated with a solution in which a copper-containing compound, a palladium-containing compound, and a gold-containing compound are contained in excess with respect to desired deposition amounts of the catalyst components, step 3, in which, after the catalyst components have been deposited in the desired deposition amounts, the carrier is separated from the solution, step 4, in which the carrier is brought into contact with water or an aqueous solution each having a pH of 7.0-11.5, step 5, in which a reduction treatment is conducted, and step 6, in which the acetic acid salt is deposited on the carrier.

The presently-disclosed subject matter includes useful water-soluble gold containing compounds and compositions, and methods of making and methods of using such compounds and compositions.

The present application relates to the field of precious metal recovery, and specifically discloses a method for recovering gold from gold ion electrolysis tail liquid; a method for recovering gold from gold ion electrolysis tail liquid, comprising the following specific steps: S1 ion exchange adsorption: after cleaning the mixed bed, soaking the ion exchange resin in sodium hydroxide solution, then loading it into the mixed bed and adding the gold tail liquid for ion exchange adsorption; S2 gold recovery: drying and carbonizing the ion exchange resin that has adsorbed the gold tail liquid to obtain a gold-containing compound, mixing and dissolving the gold-containing compound with aqua regia, using hydrochloric acid for denitrification to obtain gold aqua regia, vacuum filtering and washing, and then using anhydrous sodium sulfite for reduction to obtain reduced gold powder, which is then dried to obtain the gold powder; the ion exchange resin raw materials include cation exchange resin and carboxymethyl chitosan; the present application can enhance the adsorption capacity and adsorption rate of the ion exchange resin through the synergistic effect of various processes, thereby improving the gold recovery effect.

The present invention relates to a catalyst for preparing vinyl acetate and a preparation method therefor, and the use thereof. The preparation method comprises the following steps: kneading, drying, and shaping an ultrafine silica gel powder, ultrafine diatomaceous earth, a silica sol, and a boron compound at a weight ratio of 100: (5-20): (10-60): (0.1-1), followed by calcination at 150-650ºC for 1-6 h to prepare a boron-doped composite SiO2 carrier; subjecting the carrier to incipient wetness impregnation with rolling with a solution of palladium and gold compounds at a Pd / (Au+Pd) molar ratio of 0.76-0.93 and a loading amount of 0.5%-1% relative to the carrier mass, followed by drying; treatment with an alkaline solution for 0.5-30 h, then drying, and reduction at 300-650ºC in a nitrogen-hydrogen atmosphere for 1-6 h, and washing same with water until chlorine-free, followed by drying; preparing a dilute sol by mixing copper acetate and cesium oxide at a Cu / (Re+Cu) molar ratio of 0.93-0.97 and a loading amount of 0.3%-1% with 0.5%-3% aluminum phosphate, followed by dip coating and drying; impregnating with a potassium acetate solution at a loading amount of 0.2%-7.5%, and performing a heat treatment at a negative pressure at 60-200ºC for 1-6 h, to obtain a highly stable, long-life catalyst, which has high strength and few by-products.

This invention discloses a method for preparing gold nanospheres. The principle of this invention is based on the confinement effect of carbon cloth on the attached gold nanospheres, thereby inhibiting the agglomeration and fusion of nanoparticles under high-temperature conditions and ensuring the stable preparation of gold nanospheres. The specific preparation process is as follows: First, gold is attached to carbon cloth in the form of an oxide from a precursor solution under hydrothermal conditions. Simultaneously, the dried carbon cloth with the attached gold compound is reduced at high temperature in a tube furnace. Because the gold compound is tightly attached to the surface of the carbon cloth, the problem of gold nanosphere agglomeration and fusion is effectively avoided, and a large number of gold nanosphere particles are obtained after reduction attached to the surface of the carbon cloth. Finally, dispersed gold nanosphere particles are obtained by ultrasonication or combustion.

The invention relates to a gold-containing nano-enzyme for treating atopic dermatitis and a pharmaceutical preparation thereof, the gold-containing nano-enzyme is prepared from a manganese-zinc metal organic framework nano-enzyme and a gold-containing compound, and the manganese-zinc metal organic framework nano-enzyme is prepared from a manganese salt, a zinc salt and a metal organic framework material. According to the invention, an integrated multi-enzyme simulation platform is constructed, the hydrogel is adopted to provide preparation support for treatment of atopic dermatitis, the biocompatibility and the physical barrier function of the material are enhanced, and a solution is provided for local management of atopic dermatitis.

The invention relates to the technical field of catalytic hydrogenation, in particular to an Au-based supported catalyst and a preparation method and application thereof, and discloses a method for preparing corresponding unsaturated alcohol through pi-pi conjugated aldehyde hydrogenation. The preparation method comprises the following steps: mixing a mixture containing a carrier and a soluble gold compound with an alkaline solution containing a precipitator, regulating the pH value to 6-14, and sequentially carrying out standing, first drying, first roasting and reduction on the obtained mixed slurry to obtain the Au-based supported catalyst, wherein in the alkaline solution, the precipitator is selected from at least one of ammonia water, potassium carbonate, potassium bicarbonate, potassium hydroxide, sodium carbonate, sodium bicarbonate and sodium hydroxide. The Au-based supported catalyst provided by the invention is used for preparing corresponding unsaturated alcohol through pi-pi conjugated aldehyde hydrogenation, and the selectivity of a target product is effectively improved under relatively mild conditions.