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Method for calculating intratumor heterogeneity

A computational method, a technique of heterogeneity, applied in the field of calculation of genetic heterogeneity within tumors

Inactive Publication Date: 2020-05-05
信华生物药业(广州)有限公司
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  • Abstract
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  • Application Information

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Problems solved by technology

Finding suitable targets among the many patient-specific somatic mutations has become a major challenge for neoantigen-based vaccine design

Method used

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  • Method for calculating intratumor heterogeneity
  • Method for calculating intratumor heterogeneity
  • Method for calculating intratumor heterogeneity

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Embodiment Construction

[0030] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0031] Such as Figure 1-Figure 3 As shown, the present invention proposes a calculation method for intratumor genetic heterogeneity, which specifically includes the following steps:

[0032] S1, collecting tumor tissue samples;

[0033] The research plan and procedures for patient tumor sample collection were approved by the Ethics Committee of Quanzhou First Hospital (QYL2019-108). Three tumor tissue samples and one normal / tumor-adjacent tissue sa...

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Abstract

The invention discloses a method for calculating intratumor heterogeneity and belongs to the field of cancers. The method comprises the following steps: acquiring tumor tissue samples, and generatingmutation group data of each tissue sample; and calculating mix indexes of intratumor heterogeneity according to the mutation group data. By adopting the method, the mix indexes are calculated on the basis of mutation of sample data of each tissue sample and variation allele frequency corresponding to the mutation, the mix indexes function as indexes of intratumor heterogeneity, and a quantizationtool is provided for stratification analysis on tumor patients.

Description

technical field [0001] The invention relates to the technical field of cancer, in particular to a method for calculating genetic heterogeneity in tumors. Background technique [0002] Cancer is a major unsolved public health problem in medicine today. Intratumor heterogeneity (IGH) is an important reason why cancer problems are difficult to solve. Immunotherapy (including personalized immunotherapy), such as immune checkpoint inhibitors and personalized tumor vaccines, is emerging as a promising solution to this medical need. To facilitate effective immunotherapy, a systematic understanding and measurement of IGH is required. [0003] In the tumor microenvironment, the immune system can often recognize and eradicate tumor cells. However, tumor cells can employ a number of different strategies to suppress or "hide" from the body's immune system and thus survive various stages of antitumor immune surveillance and response. This function is called immune escape of tumor cel...

Claims

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Application Information

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IPC IPC(8): C12Q1/6858G16B20/20
CPCC12Q1/6858G16B20/20C12Q2521/107C12Q2535/122C12Q2531/113
Inventor 鲁靖黄莉莉王鲁泉
Owner 信华生物药业(广州)有限公司
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