A Screening Method for Ternary Solvent System Aiming at Particle Coalescence into Ball Technology

A ternary solvent and screening method technology, applied in the direction of instruments, surface/boundary effects, measuring devices, etc., can solve the problems of high failure rate and low efficiency, and achieve less workload, less difficult measurement, and strong scalability Effect

Active Publication Date: 2022-03-29
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the defects of blind trial and error, low efficiency and high failure rate in the screening process existing in the existing screening technology, the present invention provides a ternary solvent system screening method for particle coalescence into ball technology

Method used

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  • A Screening Method for Ternary Solvent System Aiming at Particle Coalescence into Ball Technology
  • A Screening Method for Ternary Solvent System Aiming at Particle Coalescence into Ball Technology
  • A Screening Method for Ternary Solvent System Aiming at Particle Coalescence into Ball Technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A ternary solvent system was selected from nine solvents including chloroform, isopropanol, water, toluene, carbon tetrachloride, diiodomethane, cyclohexane, ethanol, and formamide to coalesce cefotaxime sodium into balls. Specific steps are as follows:

[0052] (1) Among the 9 solvents to be selected, list all the ternary solvent combinations according to the orderly arrangement and combination method. First, randomly select a solvent from the 9 solvents to be selected as a good solvent, then randomly select a solvent from the remaining 8 solvents to be selected as a poor solvent, and then randomly select a solvent from the remaining 7 solvents to be selected. A solvent is selected as a bridging agent, and the selected three solvents are combined as a group of ternary solvents. The total number of solvent combinations is then a ternary solvent combination.

[0053] (2) In each ternary solvent combination obtained in step (1), the solubility of the particles in the ...

Embodiment 2

[0070] Select ternary solvent system in 12 kinds of solvents of chloroform, Virahol, water, toluene, carbon tetrachloride, diiodomethane, hexanaphthene, ethanol, formamide, benzene, normal hexane, methyl alcohol, make potassium chloride ( KCl) coalesced into balls. Specific steps are as follows:

[0071] (1) Among the 12 solvents to be selected, list all the ternary solvent combinations according to the orderly arrangement and combination method. First, randomly select a solvent from the 12 solvents to be selected as a good solvent, then randomly select a solvent from the remaining 11 solvents to be selected as a poor solvent, and then randomly select a solvent from the remaining 10 solvents to be selected. A solvent is selected as a bridging agent, and the selected three solvents are combined as a group of ternary solvents. The total number of solvent combinations is then a ternary solvent combination.

[0072] (2) In each ternary solvent combination obtained in step (1)...

Embodiment 3

[0088] Select a ternary solvent system among 13 solvents including chloroform, isopropanol, water, toluene, carbon tetrachloride, cyclohexane, ethanol, formamide, benzene, n-hexane, methanol, ethyl acetate, and dimethyl sulfoxide , to coalesce benzoic acid into balls. Specific steps are as follows:

[0089] (1) Among the 13 solvents to be selected, list all the ternary solvent combinations according to the orderly arrangement and combination method. First, randomly select a solvent from the 13 solvents to be selected as a good solvent, then randomly select a solvent from the remaining 12 solvents to be selected as a poor solvent, and then randomly select a solvent from the remaining 11 solvents to be selected. A solvent is selected as a bridging agent, and the selected three solvents are combined as a group of ternary solvents. The total number of solvent combinations is then a ternary solvent combination.

[0090] (2) In each ternary solvent combination obtained in step ...

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Abstract

The invention discloses a ternary solvent system screening method aimed at particle coalescence into ball technology, and the screened ternary solvent system can realize particle coalescence in the system and form spherical secondary particles. List all the ternary solvent combinations by using the ordered permutation and combination method, and screen the qualified combinations through the solubility, mutual solubility, adhesion ability and wetting ability of the solvents. Then, based on the difference in wettability of the remaining combinations, they were sorted in descending order and verified by rapid balling experiments to determine the final solvent combination that can form balls. The method of the invention significantly improves the correct rate of solvent screening, has strong universality, greatly improved efficiency, less workload, low measurement difficulty, many equipment and methods meeting measurement requirements, and can realize batch screening of a large number of substance systems and solvents.

Description

technical field [0001] The invention belongs to the technical field of crystallization in the chemical engineering industry, and in particular relates to a screening method for a ternary solvent system aimed at particle agglomeration into balls. Background technique [0002] Spherical granules have the characteristics of high fluidity, high compressibility, strong anti-caking performance, and unique taste. The preparation of spherical granule products is an effective way to endow products with unique functions and increase product added value. Therefore, they are widely used in medicine, food, fertilizer, military industry And other fields have a wide range of application value. However, solid particles, especially crystal particles, are anisotropic, and their shapes are generally non-spherical, and the preparation of spherical crystals requires the development of special strengthening techniques. At present, the most common technology is the coalescence of ternary solvent ...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): G01N13/00G01N15/00
CPCG01N13/00G01N15/00
Inventor龚俊波陈明洋余畅游姚孟惠刘岩博汤伟伟吴送姑杜世超高振国侯宝红尹秋响
OwnerTIANJIN UNIV