Ternary solvent system screening method directed at particle coalescence balling technology

A ternary solvent and screening method technology, applied to measuring devices, instruments, scientific instruments, etc., can solve problems such as low efficiency and high failure rate

Active Publication Date: 2020-05-22
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the defects of blind trial and error, low efficiency and high failure rate in the screening process existing in the existing screening technology, the present invention provides a ternary solvent system screening method for particle coalescence into ball technology

Method used

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  • Ternary solvent system screening method directed at particle coalescence balling technology
  • Ternary solvent system screening method directed at particle coalescence balling technology
  • Ternary solvent system screening method directed at particle coalescence balling technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A ternary solvent system was selected from nine solvents including chloroform, isopropanol, water, toluene, carbon tetrachloride, diiodomethane, cyclohexane, ethanol, and formamide to coalesce cefotaxime sodium into balls. Specific steps are as follows:

[0052] (1) Among the 9 solvents to be selected, list all the ternary solvent combinations according to the orderly arrangement and combination method. First, randomly select a solvent from the 9 solvents to be selected as a good solvent, then randomly select a solvent from the remaining 8 solvents to be selected as a poor solvent, and then randomly select a solvent from the remaining 7 solvents to be selected. A solvent is selected as a bridging agent, and the selected three solvents are combined as a group of ternary solvents. The total number of solvent combinations is then a ternary solvent combination.

[0053] (2) In each ternary solvent combination obtained in step (1), the solubility of the particles in the ...

Embodiment 2

[0070] Select ternary solvent system in 12 kinds of solvents of chloroform, Virahol, water, toluene, carbon tetrachloride, diiodomethane, hexanaphthene, ethanol, formamide, benzene, normal hexane, methyl alcohol, make potassium chloride ( KCl) coalesced into balls. Specific steps are as follows:

[0071] (1) Among the 12 solvents to be selected, list all the ternary solvent combinations according to the orderly arrangement and combination method. First, randomly select a solvent from the 12 solvents to be selected as a good solvent, then randomly select a solvent from the remaining 11 solvents to be selected as a poor solvent, and then randomly select a solvent from the remaining 10 solvents to be selected. A solvent is selected as a bridging agent, and the selected three solvents are combined as a group of ternary solvents. The total number of solvent combinations is then a ternary solvent combination.

[0072] (2) In each ternary solvent combination obtained in step (1)...

Embodiment 3

[0088] Select a ternary solvent system among 13 solvents including chloroform, isopropanol, water, toluene, carbon tetrachloride, cyclohexane, ethanol, formamide, benzene, n-hexane, methanol, ethyl acetate, and dimethyl sulfoxide , to coalesce benzoic acid into balls. Specific steps are as follows:

[0089] (1) Among the 13 solvents to be selected, list all the ternary solvent combinations according to the orderly arrangement and combination method. First, randomly select a solvent from the 13 solvents to be selected as a good solvent, then randomly select a solvent from the remaining 12 solvents to be selected as a poor solvent, and then randomly select a solvent from the remaining 11 solvents to be selected. A solvent is selected as a bridging agent, and the selected three solvents are combined as a group of ternary solvents. The total number of solvent combinations is then a ternary solvent combination.

[0090] (2) In each ternary solvent combination obtained in step ...

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Abstract

The invention discloses a ternary solvent system screening method aiming at a particle coalescence balling technology. The ternary solvent system obtained by screening can realize coalescence of particles in the system to form sphere-like secondary particles. All ternary solvent combinations are listed by utilizing an ordered permutation and combination method, and combinations meeting conditionsare screened according to the solubility, intersolubility, adhesion capacity and wetting capacity of solvents. And descending sort arrangement and rapid balling experimental verification are carried out on the basis of the wetting capacity difference of the remained combination to determine the solvent combination which can be balled finally. According to the method, the accuracy of solvent screening is remarkably improved, the universality is high, the efficiency is greatly improved, the workload is small, the measurement difficulty is low, multiple devices and methods meeting the measurementrequirements are provided, and batch screening of a large number of material systems and solvents can be achieved.

Description

technical field [0001] The invention belongs to the technical field of crystallization in the chemical engineering industry, and in particular relates to a screening method for a ternary solvent system aimed at particle agglomeration into balls. Background technique [0002] Spherical granules have the characteristics of high fluidity, high compressibility, strong anti-caking performance, and unique taste. The preparation of spherical granule products is an effective way to endow products with unique functions and increase product added value. Therefore, they are widely used in medicine, food, fertilizer, military industry And other fields have a wide range of application value. However, solid particles, especially crystal particles, are anisotropic, and their shapes are generally non-spherical, and the preparation of spherical crystals requires the development of special strengthening techniques. At present, the most common technology is the coalescence of ternary solvent ...

Claims

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Application Information

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IPC IPC(8): G01N13/00G01N15/00
CPCG01N13/00G01N15/00
Inventor龚俊波陈明洋余畅游姚孟惠刘岩博汤伟伟吴送姑杜世超高振国侯宝红尹秋响
OwnerTIANJIN UNIV