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Contraceptive composition with reduced cardiovascular effects

A technology for contraceptives and uses, which can be applied to medical preparations containing active ingredients, drug combinations, organic active ingredients, etc., and can solve problems such as reducing the risk of thrombosis

Pending Publication Date: 2020-09-18
ESTETRA S P R L
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These patent applications do not mention a reduction in the risk of blood clots

Method used

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  • Contraceptive composition with reduced cardiovascular effects
  • Contraceptive composition with reduced cardiovascular effects
  • Contraceptive composition with reduced cardiovascular effects

Examples

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Embodiment

[0227] Research methods

[0228] A single-centre, randomized, open-label, controlled, three-arm (arm) study was performed to evaluate a combined oral contraceptive (COC) containing 15 mg estetrol (E4) and 3 mg drospirenone (DRSP) and a combination oral contraceptive (COC) containing 30 mcg ethinyl estradiol Effects of two reference COCs of ethanol (EE) and 150 mcg levonorgestrel (LNG) or 20 mcg EE and 3 mg DRSP on endocrine function, metabolic control, and hemostasis over 6 treatment cycles.

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Abstract

The present invention relates to a contraceptive method with reduced cardiovascular effects, such as reduced thromboembolism risk, such as reduced venous thromboembolism (VTE) risk and reduced aorticthromboembolism (ATE) risk. The method of the invention comprises administering to a female mammal an effective amount of an estetrol component in combination with a progestogenic component. The method enjoys a favourable profile for thromboembolism compared to currently available methods which employs contraceptives from the so-called second, third or fourth generation.

Description

technical field [0001] The present invention relates to contraceptive methods with reduced cardiovascular effects, eg reduced risk of thromboembolism, such as reduced risk of venous thromboembolism (VTE) and reduced risk of aortic thromboembolism (ATE). [0002] The methods of the invention comprise administering to a female mammal an effective amount of a combination of an estetrol component and a progestin component. [0003] Further detailed herein, said method has favorable properties with respect to thromboembolism compared to currently available methods using so-called second, third and fourth generation contraceptives. Background technique [0004] The first generation of combined hormonal contraceptives (Combined Hormonal Contraceptives, CHC) included more than 50 μg doses of estrogen. But studies soon showed that this preparation was associated with an unacceptably increased risk of cardiovascular effects, depending on the dose of the estrogenic component. Subsequ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/565A61P15/18
CPCA61K31/585A61K31/565A61K9/0053A61P15/18A61K2300/00
Inventor M·约斯特G·劳辛
Owner ESTETRA S P R L
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