Targeted regulation of the composition of intestinal Ekmansia and short-chain fatty acid-producing bacteria

A short-chain fatty acid and composition technology, applied in the field of synbiotics composition preparation product development, can solve problems such as difficult to achieve probiotic activity, low number of viable bacteria, intolerance, etc., to improve the structure of intestinal flora, promote The effect of body health and regulation of intestinal microecology

Active Publication Date: 2022-05-27
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, it is difficult for the bacteria to tolerate the acidic environment of gastric acid and bile salt solution in the digestive tract of the body and the digestive enzymes.
As a result, the number of live bacteria in probiotic products that finally reach the intestinal target is low, making it difficult to achieve their probiotic activity

Method used

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  • Targeted regulation of the composition of intestinal Ekmansia and short-chain fatty acid-producing bacteria
  • Targeted regulation of the composition of intestinal Ekmansia and short-chain fatty acid-producing bacteria
  • Targeted regulation of the composition of intestinal Ekmansia and short-chain fatty acid-producing bacteria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The various components of the composition are calculated as the mass percentage of the composition:

[0033] (1) The probiotics added in the composition select about 10 Bifidobacterium breve 8 cfu / g, about 10 of Pediococcus pentosaceus 8 cfu / g, about 5×10 Clostridium butyricum 6 cfu / g;

[0034] (2) The composition contains 30% guar gum-derived low-molecular-weight galactomannan (1-10 kDa) and 15% alginate-derived alginate oligosaccharide (DP 2-4) as prebiotics;

[0035] (3) The composition contains bacterial cell protective agent: skim milk powder 22%, trehalose 7%, γ-polyglutamic acid 8% and glycerol 5%;

[0036] (4) The composition contains 3% of orange powder and 4% of cranberry powder as auxiliary materials.

[0037] Synbiotics preparation process:

[0038] (1) Bifidobacterium bifidum and Pediococcus pentosaceus were placed in the sterilized MRS medium, and Clostridium butyricum was placed in the RCM liquid medium for 24 hours at 37°C, and the bacteria were ac...

Embodiment 2

[0045] The components of synbiotics are calculated as the mass percentage of the composition:

[0046] (1) The probiotics added in the composition are about 5×10 Bifidobacterium lactis 7 cfu / g, about 5×10 Bifidobacterium bifidum 7 cfu / g, about 10 for Clostridium butyricum 7 cfu / g;

[0047] (2) The composition contains 32% guar gum-derived low-molecular-weight galactomannan (1-10 kDa) and 16% alginate-derived alginate oligosaccharide (DP 2-4) as prebiotics;

[0048] (3) The composition contains bacterial cell protective agent: skim milk powder 23%, trehalose 7%, γ-polyglutamic acid 7% and glycerol 5%;

[0049] (4) The composition contains 7% of pumpkin powder as an auxiliary material.

[0050] Synbiotics preparation process:

[0051] (1) Bifidobacterium lactis was inserted into the sterilized MRS medium, and Clostridium butyricum was inserted into the RCM medium for static culture for 24 hours to activate the strains;

[0052] (2) Transfer the activated bacterial liquid i...

Embodiment 3

[0057] Example 3: Pure strain synbiotic preparation

[0058] Mass percent of the composition:

[0059] (1) The bacterial strain selected in the composition is: a strain in Bifidobacterium breve, Bifidobacterium bifidum, Bifidobacterium lactis, Pediococcus pentosaceus or Clostridium butyricum, and the added probiotics are respectively 10 8 cfu / g;

[0060] (2) The composition contains 34% guar gum-derived galactomannan (1-10 kDa) and 17% alginate-derived alginate oligosaccharide (DP 2-4) as prebiotics;

[0061] (3) Contains bacterial cell protectant: skim milk powder 20%, trehalose 6%, γ-polyglutamic acid 6% and glycerol 5%. ;

[0062] Synbiotics preparation process:

[0063] (1) Bifidobacterium breve, Bifidobacterium bifidum or Bifidobacterium lactis and Pediococcus pentosaceus were inserted into the sterilized MRS medium, and Clostridium butyricum was inserted into the RCM medium for static culture for 24 hours, and then activated. strain;

[0064] (2) Transfer the activ...

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Abstract

The invention relates to a composition for targeted regulation of Ekmansia intestinalis and short-chain fatty acid producing bacteria, which belongs to the field of synbiotic composition preparation product development. The probiotics contained in the composition are 10 6 ~10 10 cfu / g, the mass percentage is 30-60% prebiotics, the mass percentage is 17-37% skim milk powder, the mass percentage is 4.5-10% trehalose, and the mass percentage is 4.5-10% γ-polyglutamic acid and 3-6% of glycerin by mass percentage; 5-10% by mass of fruit and vegetable powder. The composition of the invention can target to increase the abundance level of Ekmansia and short-chain fatty acid producing bacteria in human body, and has the functions of improving intestinal flora structure, regulating intestinal microecology, and promoting body health.

Description

technical field [0001] The invention belongs to the field of product development of synbiotic composition preparations, in particular to the development of a synbiotic combination for improving Ekmania intestinalis and short-chain fatty acid-producing bacteria based on galactomannan and fucoidan oligosaccharide compound prebiotics The preparation method of the composition, and the application of the composition in regulating intestinal flora. Background technique [0002] Probiotics refer to a class of live microorganisms that can benefit the host's health and physiological functions by improving the balance of the host's intestinal microflora. Studies have shown that the proliferation and metabolism of probiotics (such as Bifidobacterium, Lactobacillus, Ekmania muciniphila, Clostridium butyricum, etc.) in the gut can improve the intestinal microecological environment, inhibit pathogenic bacteria, repair colon damage, and improve Body immunity, lower cholesterol and blood s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L33/135A23L33/21C12N1/20C12N1/04C12R1/01C12R1/145
CPCA23L33/135A23L33/21C12N1/20C12N1/04A23V2002/00A23V2400/427A23V2400/517A23V2400/519A23V2400/531A23V2200/3204A23V2200/3202A23V2250/51A23V2250/284A23V2250/636A23V2250/6406
Inventor 牟海津魏心怡付晓丹肖梦诗
Owner OCEAN UNIV OF CHINA
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