Composition for targeted regulation of intestinal Akkermansia and short chain fatty acid producing bacteria

A short-chain fatty acid and composition technology, which is applied in the field of synbiotic composition preparation product development, can solve problems such as intolerance, low number of viable bacteria, and difficulty in achieving probiotic activity

Active Publication Date: 2020-10-27
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, it is difficult for the bacteria to tolerate the acidic environment of gastric acid and bile salt solution in the digestive tract of the body and the digestive enzymes.
As a result, the number of live bacteria in probiotic products that finally reach the intestinal target is low, making it difficult to achieve their probiotic activity

Method used

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  • Composition for targeted regulation of intestinal Akkermansia and short chain fatty acid producing bacteria
  • Composition for targeted regulation of intestinal Akkermansia and short chain fatty acid producing bacteria
  • Composition for targeted regulation of intestinal Akkermansia and short chain fatty acid producing bacteria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The various components of the composition account for the mass percentage of the composition:

[0033] (1) The probiotics added in the composition select about 10 Bifidobacterium breve 8 cfu / g, Pediococcus pentosacea about 10 8 cfu / g, Clostridium butyricum about 5×10 6 cfu / g;

[0034] (2) The composition contains 30% low-molecular-weight galactomannans (1-10 kDa) derived from guar gum and 15% fucoidan oligosaccharides (DP 2-4) derived from enzymatic hydrolysis of algin as prebiotics;

[0035] (3) The composition contains bacterium protecting agent: 22% of skim milk powder, 7% of trehalose, 8% of gamma-polyglutamic acid and 5% of glycerin;

[0036] (4) The composition contains 3% of orange powder and 4% of cranberry powder as auxiliary materials.

[0037] Synbiotics preparation process:

[0038] (1) Bifidobacterium bifidum and Pediococcus pentosacea were inserted into the sterilized MRS medium, and Clostridium butyricum was inserted into the RCM liquid medium for st...

Embodiment 2

[0045] The components of synbiotics are calculated by mass percent of the composition:

[0046] (1) The probiotics added in the composition select about 5×10 Bifidobacterium lactis 7 cfu / g, about 5×10 Bifidobacterium bifidum 7 cfu / g, Clostridium butyricum about 10 7 cfu / g;

[0047] (2) The composition contains 32% low-molecular-weight galactomannans (1-10 kDa) derived from guar gum and 16% fucoidan oligosaccharides (DP 2-4) derived from enzymatic hydrolysis of algin as prebiotics;

[0048] (3) The composition contains bacterium protecting agent: 23% of skim milk powder, 7% of trehalose, 7% of gamma-polyglutamic acid and 5% of glycerin;

[0049] (4) The composition contains 7% pumpkin powder as an auxiliary material.

[0050] Synbiotics preparation process:

[0051] (1) Bifidobacterium lactis was inserted into the sterilized MRS medium, and Clostridium butyricum was inserted into the RCM medium for static culture for 24 hours to activate the strains;

[0052] (2) Transfer...

Embodiment 3

[0057] Embodiment 3: pure strain synbiotics preparation

[0058] The mass percent meter of composition:

[0059] (1) The bacterial strain selected in the composition is: one of Bifidobacterium breve, Bifidobacterium bifidum, Bifidobacterium lactis, Pediococcus pentosaceae or Clostridium butyricum, and the added probiotics are 10 8 cfu / g;

[0060] (2) The composition contains 34% of galactomannan (1-10 kDa) derived from guar gum and 17% of fucoidan oligosaccharides (DP 2-4) derived from enzymatic hydrolysis of algin as prebiotics;

[0061] (3) Containing bacterial cell protection agent: 20% of skimmed milk powder, 6% of trehalose, 6% of gamma-polyglutamic acid and 5% of glycerin. ;

[0062] Synbiotics preparation process:

[0063] (1) Bifidobacterium breve, Bifidobacterium bifidum or Bifidobacterium lactis and Pediococcus pentosaceae were inserted into the sterilized MRS medium, Clostridium butyricum was inserted into the RCM medium for static culture for 24 hours, and acti...

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Abstract

The invention relates to a composition for targeted regulation of intestinal Akkermansia and short chain fatty acid producing bacteria, and belongs to the field of development of synbiotic compositionpreparation products. The composition contains, in percentage by mass, 10<6>-10<10> cfu / g of probiotics, 30-60% of prebiotics, 17-37% of skim milk powder, 4.5-10% of trehalose, 4.5-10% of gamma-polyglutamic acid, 3-6% of glycerin and 5-10% of fruit and vegetable powder. The composition can improve the abundance level of the Akkermansia and short chain fatty acid producing bacteria in a human bodyin a targeted manner, has the functions of improving the structure of intestinal florae, regulating the intestinal microecology, and promoting the health of organisms.

Description

technical field [0001] The invention belongs to the field of product development of synbiotic composition preparations, and specifically relates to the development of a synbiotic combination for improving intestinal Ekmansia and short-chain fatty acid-producing bacteria based on galactomannan and fucoidan oligosaccharide compound prebiotics The preparation method of the composition, and the application of the composition in regulating intestinal flora. Background technique [0002] Probiotics refer to a class of living microorganisms that can improve the host's health and physiological functions by improving the balance of the microbial flora in the host's intestines. Studies have shown that the proliferation and metabolism of probiotics in the intestine (such as Bifidobacterium, Lactobacillus, Ekmansia muciniphila, Clostridium butyricum, etc.) can improve the intestinal micro-ecological environment, inhibit pathogenic bacteria, repair colon damage, and improve Immunity, lo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135A23L33/21C12N1/20C12N1/04C12R1/01C12R1/145
CPCA23L33/135A23L33/21C12N1/20C12N1/04A23V2002/00A23V2400/427A23V2400/517A23V2400/519A23V2400/531A23V2200/3204A23V2200/3202A23V2250/51A23V2250/284A23V2250/636A23V2250/6406
Inventor 牟海津魏心怡付晓丹肖梦诗
Owner OCEAN UNIV OF CHINA
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