Application of vsm in preparation of medicine for treating rhabdomyosarcoma

Abstract

The invention provides the application of VSM in the preparation of medicine for treating rhabdomyosarcoma. VSM can actin cytoskeleton, reduce the motility, invasiveness, colony formation, growth and proliferation levels of tumor cells, and then lead to metabolic shutdown, has effective actin filament stabilization, and has low side effects, and can treat pediatric alveolar striated muscle sarcoma.

Description

technical field

[0001] The invention relates to the field of medicine, in particular to the application of VSM in preparing a medicine for treating rhabdomyosarcoma. Background technique

[0002] The disclosure of information in this Background section is only for enhancement of understanding of the general background of the invention and should not necessarily be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art.

[0003] Rhabdomyosarcoma (RMS) is the most common childhood soft tissue tumor, accounting for approximately 6-8% of all childhood malignancies. The RMS tumor type originates from skeletal muscle cells and arises from failure of the myogenic differentiation program. RMS can be histologically divided into several subtypes. The two most common subtypes are embryonal (RME; 70%) and alveolar (RMA; 20%). The most challenging issues in treating patients with RMS are pr...

Examples

Embodiment Construction

[0036] The present invention will be further described below in conjunction with specific embodiments. It should be understood that these examples are only used to illustrate the present invention and not to limit the scope of the present invention. In the following examples, the experimental methods without specific conditions are usually in accordance with conventional conditions or in accordance with the conditions suggested by the manufacturer.

[0037] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. The reagents or raw materials used in the present invention can be purchased through conventional channels. Unless otherwise specified, the reagents or raw materials used in the present invention are used in a conventional manner in the art or in accordance with product instructions. In addition, any methods and materials similar or equivalent to those described can be used in th...

technical field

[0001] The invention relates to the field of medicine, in particular to the application of VSM in preparing a medicine for treating rhabdomyosarcoma. Background technique

[0002] The disclosure of information in this Background section is only for enhancement of understanding of the general background of the invention and should not necessarily be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art.

[0003] Rhabdomyosarcoma (RMS) is the most common childhood soft tissue tumor, accounting for approximately 6-8% of all childhood malignancies. The RMS tumor type originates from skeletal muscle cells and arises from failure of the myogenic differentiation program. RMS can be histologically divided into several subtypes. The two most common subtypes are embryonal (RME; 70%) and alveolar (RMA; 20%). The most challenging issues in treating patients with RMS are pr...

Examples

Embodiment Construction

[0036] The present invention will be further described below in conjunction with specific embodiments. It should be understood that these examples are only used to illustrate the present invention and not to limit the scope of the present invention. In the following examples, the experimental methods without specific conditions are usually in accordance with conventional conditions or in accordance with the conditions suggested by the manufacturer.

[0037] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. The reagents or raw materials used in the present invention can be purchased through conventional channels. Unless otherwise specified, the reagents or raw materials used in the present invention are used in a conventional manner in the art or in accordance with product instructions. In addition, any methods and materials similar or equivalent to those described can be used in th...

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