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5-hydroxy-1, 7-diphenyl-3-heptanone separated from galangal and application thereof

A technology of diphenyl and galangal, applied in the separation/purification of carbonyl compounds, active ingredients of ketones, metabolic diseases, etc., can solve problems such as deficiency, improve glucose tolerance, improve IR effect, and reduce random blood sugar levels Effect

Inactive Publication Date: 2021-04-13
HAINAN MEDICAL COLLEGE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the current report lacks more in-depth research, and cannot well determine the specific effects of 5-hydroxy-1,7-diphenyl-3-heptanone isolated and extracted from galangal on diabetes

Method used

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  • 5-hydroxy-1, 7-diphenyl-3-heptanone separated from galangal and application thereof
  • 5-hydroxy-1, 7-diphenyl-3-heptanone separated from galangal and application thereof
  • 5-hydroxy-1, 7-diphenyl-3-heptanone separated from galangal and application thereof

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Embodiment Construction

[0025] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0026] A kind of 5-hydroxyl-1,7-diphenyl-3-heptanone isolated in galanga, the method for separating comprises the steps:

[0027] Galanga extract extraction steps: 42kg of galangal is pulverized, 80% ethanol is heated and refluxed 3 times, each time for 2h, the ratio of solid to liquid is 1:10, the combined filtrate is concentrated to 10L to obtain; separation and purification: a small amount of galangal extract is separated into liquid Add a lar...

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Abstract

The invention discloses 5-hydroxy-1, 7-diphenyl-3-heptanone separated from galangal and application of the 5-hydroxy-1, 7-diphenyl-3-heptanone. After the 5-hydroxy-1, 7-diphenyl-3-heptanone is intervened, sugar tolerance is obviously improved, and the effect of the 5-hydroxy-1, 7-diphenyl-3-heptanone on improving IR is obvious. The compound can up-regulate the transcriptional level of Nrf2 mRNA and downstream target genes.

Description

technical field [0001] The invention relates to the technical field of natural medicines, in particular to 5-hydroxyl-1,7-diphenyl-3-heptanone isolated from galangal and an application thereof. Background technique [0002] Galangal is the dry rhizome of Alpinia officinarum Hance, a plant of the ginger family Zingiberaceae. It has the effects of warming the middle and dispelling cold, warming and relieving pain, harmonizing the stomach, and promoting qi and guiding stagnation. It is often used clinically to treat abdominal cold pain , stomach cold, vomiting and other symptoms. Chemical studies have shown that galangal mainly contains flavonoids, volatile oils and diphenylheptane compounds. Pharmacological studies have found that it has various pharmacological effects such as anti-diabetes, anti-ulcer, anti-emetic, and anti-inflammatory. It has been reported that galangal extract has a significant hypoglycemic effect. Domestic studies have also reported that galangal extra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/245C07C45/79C07C45/80C07C45/82C07C45/78A61P3/10A61P3/06A61P3/00A61P3/04A61P9/00A61P19/06A61K31/12
CPCC07C45/79C07C45/80C07C45/82C07C45/78C07C49/245A61P3/10A61P3/06A61P3/00A61P3/04A61P9/00A61P19/06
Inventor 张俊清李海龙赖伟勇李丽张钰昕刘爱霞李湘怡谢振蕊周明艳
Owner HAINAN MEDICAL COLLEGE
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