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5-hydroxy-7-(4-hydroxy-3-methoxyphenyl) 1-phenyl-3-heptanone separated from galangal and application of 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl) 1-phenyl-3-heptanone

A technology of methoxyphenyl and galangal, which is applied in the field of separating 5-hydroxy-7-1-phenyl-3-heptanone from galangal, can solve problems such as deficiency, and achieve improved glucose tolerance and random blood sugar levels. The effect of reducing and improving the IR effect

Pending Publication Date: 2021-06-04
HAINAN MEDICAL COLLEGE
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  • Description
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Problems solved by technology

However, the current report lacks deeper research, and it cannot be well determined that 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl) 1-phenyl-3-heptanone isolated from Galangal The Specific Effects of Diabetes

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  • 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl) 1-phenyl-3-heptanone separated from galangal and application of 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl) 1-phenyl-3-heptanone
  • 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl) 1-phenyl-3-heptanone separated from galangal and application of 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl) 1-phenyl-3-heptanone
  • 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl) 1-phenyl-3-heptanone separated from galangal and application of 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl) 1-phenyl-3-heptanone

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[0024] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0025] 5-hydroxyl-7-(4-hydroxyl-3-methoxyphenyl) 1-phenyl-3-heptanone isolated from galanga, the separation method comprises the following steps;

[0026] Galangal extract extraction: 42kg of galangal is pulverized, heated and refluxed 3 times with 80% ethanol, each time for 2h, the ratio of solid to liquid is 1:10, and the combined filtrate is concentrated to 10L to obtain; separation and purification to prepare galangal extract: take a small amount of galanga...

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Abstract

The invention discloses 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl) 1-phenyl-3-heptanone separated from galangal and application of the 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl) 1-phenyl-3-heptanone. A separation method comprises the following steps: crushing 42kg of galangal, heating and refluxing for three times by using 80% ethanol, heating and refluxing for 2 hours each time according to a solid-liquid ratio of 1: 10, combining filtrates, and concentrating to 10L to obtain a galangal extract; taking 55g of the galangal extract, loading the galangal extract on a column according to the ratio of 1: 7 (silica gel), wherein the loading amount of the silica gel is 385g, and a silica gel is 55g; carrying out elution at the eluent ratio of petroleum ether to ethyl acetate is (30: 1), (25: 1), (20: 1), (15: 1), (10: 1), (5: 1) and (5: 3); and eluting with petroleum ether and ethyl acetate in a ratio of 10: 1 to obtain the 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl) 1-phenyl-3-heptanone monomer. The galangal extract has a remarkable effect of improving IR. The compound can up-regulate the transcriptional level of Nrf2mRNA and downstream target genes.

Description

technical field [0001] The invention relates to the technical field of natural medicines, in particular to the separation of 5-hydroxyl-7-(4-hydroxyl-3-methoxyphenyl)1-phenyl-3-heptanone from galanga and its application. Background technique [0002] Galangal is the dry rhizome of Alpinia officinarum Hance, a plant of the ginger family Zingiberaceae. It has the effects of warming the middle and dispelling cold, warming and relieving pain, harmonizing the stomach, and promoting qi and guiding stagnation. It is often used clinically to treat abdominal cold pain , stomach cold vomiting and other symptoms. Chemical studies have shown that galangal mainly contains flavonoids, volatile oils and diphenylheptane compounds. Pharmacological studies have found that it has various pharmacological effects such as anti-diabetes, anti-ulcer, anti-emetic, and anti-inflammatory. It has been reported that galangal extract has a significant hypoglycemic effect. Domestic studies have also re...

Claims

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Application Information

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IPC IPC(8): C07C45/78C07C45/79C07C49/255A61K31/12A61P3/00A61P3/04A61P3/06A61P3/10A61P5/50A61P19/06A61P9/00A23L33/105
CPCC07C45/78C07C45/79A61K31/12A61P3/00A61P3/04A61P3/06A61P3/10A61P5/50A61P19/06A61P9/00A23L33/105A23V2002/00
Inventor 张俊清李海龙赖伟勇李丽张钰昕刘爱霞李湘怡谢振蕊周明艳
Owner HAINAN MEDICAL COLLEGE
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