Separation and identification of anti-migraine effective components in Duijinsan and application of anti-migraine effective components in Duijinsan
A technology of wine making and chrysin, which is applied in medical preparations containing active ingredients, organic active ingredients, organic chemistry, etc., can solve the problems that have not yet been treated with Scutellaria baicalensis and rhubarb in treating migraine, and achieve remarkable results
Pending Publication Date: 2021-04-27
CHINA PHARM UNIV
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Problems solved by technology
Modern studies on the chemical constituents and pharmacological effects of Scutellaria baicalensis and rhubarb are relatively
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The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses separation and identification of anti-migraine effective components in Duijinsan and application of the anti-migraine effective components in the Duijinsan. The anti-migraine effective components in the Duijinsan are screened and selected from any one monomeric compound or a mixture composed of more than one monomeric compound in any proportion of baicalin, chrysin-7-O-beta-D-glucuronide, oroxylin A-7-O-beta-D-glucuronide, chrysin-6-C-arabinose-8-C-glucoside and chrysin-6-C-glucose-8-C-arabinoside. A research result shows that the monomeric compound obtained through separation has a remarkable effect in an anti-migraine medicine.
Description
technical field [0001] The invention belongs to the field of discovery and application of effective components of traditional Chinese medicine compound prescriptions for treating migraine, and particularly relates to the separation, identification and application of the effective components of "Dujinsan" for treating migraine. Background technique [0002] Migraine is a primary disorder of the central nervous system with unilateral or bilateral throbbing headaches. Its etiology is relatively complex. The release of certain neuropeptides, such as CGRP, causes excessive expansion of the walls of adjacent intracranial vessels, resulting in fluctuating headaches. At the same time, it leads to changes in vascular permeability, leakage of plasma components, activation of platelets, degranulation of mast cells, aseptic inflammation, and a vicious circle. Studies on trigeminal nerve cells have shown that under conditions of neurogenic inflammation, the release of CGRP from trigemin...
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Login to view more IPC IPC(8): A61K31/7048A61P25/06C07H1/08C07H17/07
CPCA61K31/7048A61P25/06C07H1/08C07H17/07
Inventor 张春凤郑果甘露
Owner CHINA PHARM UNIV
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