Hydrogel motor for guiding T cell chemotaxis and application thereof
A hydrogel and motor technology, applied in the direction of animal cells, vertebrate cells, cell culture active agents, etc., can solve the problem of immune cell chemotaxis failure, and achieve excellent control precision and good biocompatibility Effect
Active Publication Date: 2021-06-15
SUN YAT SEN UNIV
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[0044] The conception and technical effects of the present invention will be clearly and completely described below in conjunction with the embodiments, so as to fully understand the purpose, features and effects of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, rather than all of them. Based on the embodiments of the present invention, other embodiments obtained by those skilled in the art without creative efforts belong to The protection scope of the present invention.
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Abstract
The invention discloses a hydrogel motor for guiding T cell chemotaxis and application of the hydrogel motor. The hydrogel motor comprises a chemotactic factor. The invention designs a spiral hydrogel magnetic micromotor through a device which is easy to manufacture and is universal, and magnetic Fe3O4 nanoparticles arranged in the hydrogel motor allow remote magnetic field driving and control. The wireless control provides good biocompatibility and excellent control precision, a porous hydrogel structure also provides high capacity of chemotactic factor loading and retention release. The spiral motor driven by a rotating magnetic field can accurately reach a target lesion site, and sends a chemotactic factor signal to an immune following cell to generate directed T cell chemotaxis or recruitment towards a chemotactic factor release site.
Description
technical field [0001] The invention belongs to the field of biomaterials, in particular to a hydrogel motor for guiding T cell chemotaxis and its application. Background technique [0002] Chemotaxis refers to the directional migration of organisms along chemical gradient cues in the external environment. Nature provides a biological system of chemotaxis. For example, houseflies may be attracted to the smell of rotting food, bacteria gather to areas of high glucose concentration, and cells migrate along concentration gradients of cytokines. For cell chemotaxis behavior, the leader cell is an important role, it accurately senses the gradient and guides the direction of the cluster, while the follower cells move along through the combination of chemokine (from the leader cell)-receptor (on the follower cell) moves in the direction of the cluster with finite error. [0003] Collective migration of immune cell populations to diseased sites is an important innate immune respo...
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Login to View More IPC IPC(8): A61K9/06A61K38/19A61K41/00A61K47/02A61K47/32A61P37/02C12N5/0783
CPCA61K9/06A61K47/32A61K41/00A61K47/02A61K38/195A61P37/02C12N5/0636C12N2501/21C12N2533/30C12N2533/20
Inventor 彭飞王珍付冬梅
Owner SUN YAT SEN UNIV