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Application of arbidol in preparation of drug for prevention or treatment of diseases caused by SARS-CoV-2 virus

A sars-cov-2, use technology, applied in the field of use of arbidol in the preparation of medicines for preventing or treating diseases caused by SARS-CoV-2 virus, which can solve the problems of no one reporting

Pending Publication Date: 2021-09-17
CSPC OUYI PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature to disclose and confirm the effect of Abidol in the prevention or treatment of SARS-CoV-2 virus infection, and no one has reported whether Abidol has an inhibitory effect on the inflammatory storm caused by SARS-CoV-2 virus infection

Method used

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  • Application of arbidol in preparation of drug for prevention or treatment of diseases caused by SARS-CoV-2 virus
  • Application of arbidol in preparation of drug for prevention or treatment of diseases caused by SARS-CoV-2 virus
  • Application of arbidol in preparation of drug for prevention or treatment of diseases caused by SARS-CoV-2 virus

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Embodiment Construction

[0019] The technical solutions of the present invention will be further described in detail below in conjunction with specific embodiments. The following examples are only to illustrate and explain the present invention, but should not be construed as limiting the protection scope of the present invention. All technologies realized based on the above contents of the present invention are covered within the scope of protection intended by the present invention.

[0020] Unless otherwise stated, the raw materials and reagents used in the following examples are commercially available or can be prepared by known methods.

[0021] 1. Experimental materials:

[0022] 1. Test drug: Arbidol hydrochloride.

[0023] 2. Cells: VeroE6 and Huh-7 cells, provided by the virus room of the State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health.

[0024] 3. Virus: SARS-CoV-2, titer is TCID 50 =10 -6 / 100μL, provided by BSL-3 Laboratory of Guangzhou Customs ...

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Abstract

The invention provides application of arbidol or pharmaceutically acceptable salt thereof in preparation of a drug for the prevention or treatment of SARS-CoV-2 virus. The invention discovers and proves for the first time that arbidol hydrochloride has an inhibiting effect on cytopathy caused by infection of Vero E6 cells by novel coronavirus SARS-CoV-2 in vitro, can obviously inhibit mRNA overexpression of SARS-CoV-2 induced inflammatory factors TNF-a, IL-6, MCP-1 and IP-10, and can be quickly applied to resisting SARS-CoV-2 virus infection and relieving epidemic situation.

Description

technical field [0001] The present invention relates to the new medicinal use of Arbidol, in particular to the application of Arbidol in the preparation of medicines for preventing or treating diseases caused by SARS-CoV-2 virus. Background technique [0002] Coronaviruses belong to the order Nesting Viridae, the family Coronaviridae, and the genus Coronaviridae. They are a class of RNA viruses with an envelope and a linear single-stranded positive strand genome. They are a large class of viruses that exist widely in nature. The 5' end of the viral genome has a methylated cap structure, and the 3' end has a poly(A) tail. The total length of the genome is about 27-32 kb, and it is the virus with the largest genome among known RNA viruses. Coronaviruses only infect vertebrates and are related to a variety of diseases in humans and animals, and can cause respiratory, digestive and nervous system diseases in humans and animals. [0003] The 2019 novel coronavirus (SARS-CoV-2, a...

Claims

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Application Information

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IPC IPC(8): A61K31/4045A61K45/06A61P31/14A61P11/00
CPCA61K31/4045A61K45/06A61P31/14A61P11/00A61K2300/00
Inventor 杨子峰钟南山褚苍丽王莉芳申东民叶枫燕海潮曹亚青李润峰
Owner CSPC OUYI PHARM CO LTD
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