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A kind of uspio-mof assembly body and its preparation method and application

A technology of assembly and antibody, which is applied in the field of USPIO-MOF assembly and its preparation, can solve the problems such as the inability to detect small molecules, and achieve the effect of increasing the apparent diffusion coefficient, high-throughput detection, and improving the transverse relaxation rate

Active Publication Date: 2022-02-18
CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although higher sensitivity and better reproducibility have been achieved, it is still unable to detect small molecules that require very high sensitivity

Method used

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  • A kind of uspio-mof assembly body and its preparation method and application
  • A kind of uspio-mof assembly body and its preparation method and application
  • A kind of uspio-mof assembly body and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]A USPIO-MOF assembly, comprising a USPIO material combined with a first antigen or a first antibody, a MOF material combined with a second antibody or a second antigen, the first antigen and the second antibody or the first antibody and the second antibody Through specific binding, the USPIO material is assembled on the surface of the MOF material to form a USPIO-MOF assembly.

[0038] The preparation method of this USPIO-MOF assembly comprises the following steps:

[0039] S1. Combining the USPIO material with the first antigen or the first antibody;

[0040] S2. Combining the MOF material with a second antibody or a second antigen;

[0041] S3. The USPIO material combined with the first antigen or the first antibody and the MOF material combined with the second antibody or the second antigen are formed into an assembly through antigen-antibody specific binding.

[0042] More specifically, the preparation method of the USPIO-MOF assembly of this embodiment includes th...

Embodiment 2

[0063] The USPIO-MOF assembly prepared in Example 1 was used as a magnetic relaxation switch sensor to detect bisphenol A.

[0064] Bisphenol A (BPA) is an important raw material widely used in the production of baby feeding bottles, dental fillings and the lining of food jars. The residues of BPA in food mainly come from food raw materials and food packaging materials. Considered an endocrine-disrupting chemical, numerous studies have shown that BPA may contribute to reproductive disorders including neurological and behavioral changes in infants and children, diabetes, hyperactivity, obesity and various cancers such as Breast, prostate and testicular cancer. my country's "Drinking Water Hygienic Standard" GB5749-2006 stipulates that the limit of BPA is 0.01mg / L. Specific migration or maximum residue shall not exceed 0.6mg / kg. We construct a magnetic relaxation switch sensor based on USPIO and MOF for the detection of BPA.

[0065] (1) Establishment of BPA standard curve

...

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Abstract

The present invention provides a USPIO-MOF assembly and its preparation method and application. The assembly includes a USPIO material combined with a first antigen or a first antibody and a second antibody or antibody corresponding to the first antigen or first antibody. The second antigen-binding MOF material, the USPIO material and the MOF material form an assembly through antigen-antibody specific binding. By assembling USPIO on the surface of MOF, the assembly reduces the entry of water molecules into the assembly, increases the apparent diffusion coefficient of the assembly, and further increases its transverse relaxation rate to improve the sensitivity of the magnetic relaxation switch sensor.

Description

technical field [0001] The present invention relates to the field of nanomaterial science, more specifically, to a USPIO-MOF assembly and its preparation method and application. Background technique [0002] In recent years, magnetic relaxation switch sensors based on state changes of magnetic nanoparticles have received increasing attention in modern analysis. Magnetic relaxation switch sensors have been widely used to detect different targets, such as heavy metals, bacteria, pesticides, viruses, and antibiotics. Compared with the current detection mode, the magnetic relaxation switch sensor has more anti-interference performance for the detection of food samples, because the magnetic relaxation switch sensor is uniform and independent of light, and the magnetization of most food samples rate can be ignored. [0003] However, the traditional magnetic relaxation switch sensor is not suitable for the analysis of trace target substances due to its low sensitivity. To addres...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N24/08H01F1/42
CPCG01N24/08H01F1/42Y02A90/30
Inventor 许宙陈艳秋程云辉丁利陈茂龙戴诗勤文李焦叶
Owner CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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