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Methods to predict liver disease mortality using lipoprotein lp-z

A technology of LP-Z and lipoprotein, which is applied in the field of determination of lipoprotein components in plasma and serum, and can solve problems such as unreliable prediction of mortality

Pending Publication Date: 2021-11-05
LIPOSCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these scores cannot reliably predict mortality and guide clinical decisions regarding liver transplantation

Method used

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  • Methods to predict liver disease mortality using lipoprotein lp-z
  • Methods to predict liver disease mortality using lipoprotein lp-z
  • Methods to predict liver disease mortality using lipoprotein lp-z

Examples

Experimental program
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Embodiment approach 1

[0066] Illustrative embodiment 1 is a method of predicting patient mortality in alcoholic hepatitis comprising: acquiring an NMR spectrum of a biological sample obtained from a subject; programmatically determining, based on the NMR spectrum of the sample, LP-Z and total apoB-containing lipoprotein concentrations, wherein the NMR spectrum of the sample includes LP-X and LP-Z; and calculating a Z-index score.

[0067] Illustrative embodiment 2 is the method of any preceding or subsequent embodiment, wherein the obtaining step of the method comprises: generating a measured lipid signal profile for an NMR spectrum of a biological sample obtained from the subject; and generating a Calculate alignment.

[0068] Illustrative embodiment 3 is the method of any preceding or subsequent embodiment, wherein the calculated profile is based on derived concentrations of lipoprotein fractions comprising LP-X and LP-Z.

[0069] Illustrative embodiment 4 is the method of any preceding or subse...

Embodiment approach 16

[0085] Illustrative Embodiment 16 is an NMR analyzer comprising:

[0086] NMR spectrometer;

[0087] a probe in communication with the spectrometer; and

[0088] a controller in communication with the spectrometer, the controller configured to obtain an NMR signal defining a single peak region of the NMR spectrum associated with the LP-Z of the fluid sample in the probe and generate a patient-provided LP-Z level Report.

[0089] Illustrative embodiment 17 is the analyzer of any preceding or subsequent embodiment, wherein the controller is in communication with at least one local or remote processor, wherein the at least one processor is configured to:

[0090] (i) obtaining a composite NMR spectrum of the fitted region of the fluid sample; and

[0091] (ii) Deconvolve the composite NMR spectrum using a defined deconvolution model to generate LP-Z levels.

[0092] Illustrative embodiment 18 is the analyzer of any preceding or subsequent embodiment, wherein the deconvolution...

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Abstract

Described herein are methods for the determination of patient mortality from alcoholic hepatitis in biosamples by NMR spectroscopy and more specifically for the determination of a Z index score based on lipoprotein constituent LP-Z in blood plasma and serum.

Description

[0001] related application [0002] This application claims the benefit of priority to U.S. Provisional Patent Application Serial No. 62 / 757,505, filed November 8, 2018, the contents of which are incorporated herein by reference as if fully set forth herein. technical field [0003] Described herein are methods and systems for determining constituents in plasma and serum, and more particularly for determining lipoprotein constituents in plasma and serum. Background technique [0004] Alcoholic hepatitis (AH) is a common cause of hospital admission for liver disease hospitalized patients in the United States. Among the spectrum of alcoholic liver diseases, AH causes the most acute manifestations, with a mortality rate of 5-10% in all patients and as high as 30-50% in severe forms. Unlike other forms of liver failure, AH manifestations are characterized by severe blood clotting defects (coagulopathy) and stagnation of bile (cholestasis), which can occur without significant he...

Claims

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Application Information

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IPC IPC(8): G01N33/92G01N24/00
CPCG01N33/92G01N2800/52G01N2800/085G01R33/465G01N24/08A61B5/055A61B5/145G01R33/4625G16B40/10G16H50/30
Inventor Z·G·蒋J·D·奥特沃斯I·沙劳罗瓦E·J·耶亚拉加赫M·A·康奈利M·库里N·阿夫达尔Y·波波夫M·佩雷斯马托斯
Owner LIPOSCI
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