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Nanopore sequencing circuit, sequencing method and device

A nanopore sequencing and circuit technology, which is applied in the field of nanopore sequencing, can solve problems such as difficult to achieve resistance and achieve accurate sequencing results

Active Publication Date: 2021-11-26
QITAN TECH LTD CHENGDU
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in integrated circuit design, it is difficult to realize resistors with resistance values ​​up to the order of gigaohms using passive components.

Method used

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  • Nanopore sequencing circuit, sequencing method and device
  • Nanopore sequencing circuit, sequencing method and device
  • Nanopore sequencing circuit, sequencing method and device

Examples

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Embodiment Construction

[0053]The characteristics and exemplary embodiments of various aspects of the application will be described in detail below. In order to make the purpose, technical solution and advantages of the application clearer, the application will be further described in detail below in conjunction with the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described here are only intended to explain the present application rather than limit the present application. It will be apparent to one skilled in the art that the present application may be practiced without some of these specific details. The following description of the embodiments is only to provide a better understanding of the present application by showing examples of the present application.

[0054] In order to better understand the present application, before introducing the specific implementation of the present application, a brief introduction of related technologies i...

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Abstract

The invention discloses a nanopore sequencing circuit, a sequencing method and a device. The nanopore sequencing circuit comprises at least one signal detection circuit and an analog-to-digital conversion circuit, wherein the input end of the signal detection circuit is connected with a nanopore sequencing channel, and the output end of the signal detection circuit is connected with the input end of the analog-to-digital conversion circuit; the signal detection circuit comprises a current amplification circuit and a voltage conversion circuit, wherein the input end of the current amplification circuit is connected with the nanopore sequencing channel, and the current amplification circuit is used for amplifying a current signal generated in the nanopore sequencing channel; the input end of the voltage conversion circuit is connected with the output end of the current amplification circuit, the output end of the voltage conversion circuit is connected with the input end of the analog-to-digital conversion circuit, and the voltage conversion circuit is used for converting the amplified current signal into a voltage signal; and the analog-to-digital conversion circuit is used for converting the voltage signal into a digital signal. Through the circuit, a sequencing signal can be accurately acquired.

Description

technical field [0001] The present application belongs to the technical field of nanopore sequencing, and in particular relates to a nanopore sequencing circuit, a sequencing method and a device. Background technique [0002] At present, the nanopore gene sequencer measures the current signal flowing through the membrane nanopore to deduce the gene sequence passing through the membrane nanopore. The current signal is very weak, usually on the order of tens of picoamperes. Usually, in the nanopore sequencing circuit, a transimpedance amplifier circuit is used to convert the microcurrent signal into a voltage signal for amplification, and an analog-to-digital conversion circuit is used to sample the amplified voltage signal to obtain corresponding measurement results. [0003] However, usually in a transimpedance amplification circuit, high-value resistors (on the order of hundreds of megohms to several gigaohms) are required to amplify the tiny current flowing through the na...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6869
CPCC12Q1/6869C12Q2535/122C12Q2565/631
Inventor 鄂强王琎
Owner QITAN TECH LTD CHENGDU
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