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Application of boningmycin in treatment of drug-resistant tuberculosis

A technology of boningmycin and drug resistance, which is applied in the field of tuberculosis treatment, can solve the problems of being unable to be effectively treated, and achieve the effects of significant inhibition of activity, low production cost and high activity

Pending Publication Date: 2021-12-03
MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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  • Abstract
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AI Technical Summary

Problems solved by technology

However, there are still more than 500,000 drug-resistant MTB strains that cannot be effectively treated in the world (7), and the clinical demand for new anti-TB drugs is still urgent

Method used

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Examples

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Embodiment Construction

[0042] The following examples of the embodiments in conjunction with embodiments of the present invention will be described in detail, those skilled in the art will appreciate that the following examples merely illustrate the invention and should not be construed as limiting the scope of the present invention. In the examples, the specific conditions are not indicated, followed by conventional conditions or manufacturers. The reagents or instruments used are not indicated by the manufacturer, all of which can be obtained through the market.

[0043] Boningmycin (hydrochloride) is a new microbial products Institute of Chinese Academy of Medical Pharmaceutical Biotechnology, isolated from soil in Pingyang City, Zhejiang Province to Streptomyces verticillus var Duong fermentation, which can be prepared according to China invention patent application CN 98101253.1, Title: an antitumor antibiotics and their microbial fermentation process.

[0044] 1. strain recovery

[0045] MTB used i...

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PUM

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Abstract

The invention relates to application of boningmycin in treatment of drug-resistant tuberculosis, in particular to application of the boningmycin or pharmaceutically acceptable salts thereof in preparation of drugs. The drugs are used for (1) inhibiting growth or proliferation of mycobacterium tuberculosis; (2) killing or damaging the mycobacterium tuberculosis; (3) inhibiting mycobacterium tuberculosis infection; and / or (4) treating diseases caused by the mycobacterium tuberculosis infection. Results show that the boningmycin has remarkable inhibitory activity on sensitive and drug-resistant mycobacterium tuberculosis, has the advantages of high activity and low production cost, and provides a new choice for tuberculosis treatment.

Description

Technical field [0001] The present invention is in the field of treatment of tuberculosis, in particular, to the application 72 from the fermentation of Streptomyces verticillus var Duong (StreptomycesVerticillus var.Pingyangensis n.Var) product isolated boningmycin (Boningmycin) in the treatment of drug-resistant TB. Background technique [0002] TB (Tuberculosis, TB) is an infectious disease with high lethality by Mycobacterium tuberculosis (Mycobacterium tuberculosis, MTB) caused by infection, it is the highest mortality (1) unity of the source of infection caused. Worldwide, about two billion people carry MTB, our country is the second-highest incidence of TB in the country, of which 5% to 10% of people will be likely to develop TB patients. DOTS program can save the lives of 85% of TB patients. New applications and combinations of anti-TB drugs, making TB prevalence and mortality with respect to 2000 has been reduced to some extent. But TB prevention and control situation is...

Claims

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Application Information

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IPC IPC(8): A61K38/14A61K45/06A61P31/06
CPCA61K38/14A61K45/06A61K9/0053A61K9/0019A61P31/06
Inventor 蒙建州何琪杨解云英陈阳陈汝贤许鸿章
Owner MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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