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Microfluidic chip architecture with optimized phase flow

A microfluidic chip and microchannel technology, applied in fluid controllers, laboratory appliances, laboratory containers, etc., can solve the problems of unconfigured chambers and unsuitable storage of droplets, etc., to increase the number of droplets /Surface ratio, optimized detection reproducibility and accuracy, optimized space occupation effects

Active Publication Date: 2022-02-11
STILLA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the chamber is not configured to store droplets, nor is it suitable for storing droplets

Method used

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  • Microfluidic chip architecture with optimized phase flow
  • Microfluidic chip architecture with optimized phase flow
  • Microfluidic chip architecture with optimized phase flow

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Embodiment Construction

[0093] The present disclosure provides components, devices, systems, devices and methods for performing droplet-based detection using microfluidic chips. These may involve, for example, preparing samples for analysis (such as clinical or environmental samples); separating sample components by dividing these components into droplets or other partitions, each containing only one or a few components (e.g., a single copy of a nucleic acid target or other analyte of interest); amplify or otherwise react components within a droplet or partition; detect amplified or reacted components or their characteristics; and / or analyze generated data. In this way, complex samples can be transformed into multiple simpler, easier-to-analyze samples while reducing background and analysis time.

[0094] The following detailed description is better understood when read in conjunction with the accompanying figures. For purposes of illustration, apparatuses, systems and devices are shown in presentl...

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Abstract

The present invention relates to a microfluidic chip (300) comprising an inlet channel and an output channel in close proximity; systems comprising the same configured to flow a continuous phase without disrupting the integrity of a population of dispersed phase droplets and / or to homogenize a locally static continuous phase throughout droplet loading or generation; and methods using the same.

Description

[0001] The present invention relates to microfluidic chips for generating liquid droplets for nucleic acid amplification and analysis. Background technique [0002] Microfluidic processes typically use emulsions, which contain droplets of a dispersed liquid phase surrounded by an immiscible continuous liquid phase. Droplets can be used as reaction vessels for chemical or biological reactions, storage vessels, and / or methods for separating and compartmentalizing molecules such as chemical or biological elements. By using the right chemicals, such as surfactants on the droplet surface, the droplets can be made "stabilized," meaning they don't essentially mix and merge when they come into contact with each other. This stability allows one to create populations, or libraries, of droplets composed of different chemical or biological components that can be stored in roughly the same volume of space without intersecting components of one droplet and another. Mixing or contamination ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00B01L7/00
CPCB01L3/502784B01L7/52B01L2200/027B01L2200/0631B01L2200/0673B01L2300/0819B01L2300/0838B01L2400/0688B01L7/00B01L3/00
Inventor 尼古拉斯·费尔南德斯艾蒂安·弗拉代雷米·当格拉大卫·肖万
Owner STILLA TECH