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Green tea polyphenol anti-caries coating film

A technology of green tea polyphenols and tea polyphenols, applied in the field of stomatology, can solve the problems of deposition, promotion of tartar, uncertain biological safety, etc.

Inactive Publication Date: 2005-06-08
SHANGHAI SECOND MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, these coatings also have certain problems, such as the relatively high concentration of fluoride in the fluorine-containing coatings, and there are uncertain factors in terms of biological safety; long-term use of chlorhexidine coatings will cause bacterial flora imbalance, promote calculus deposition, Pigmentation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Put 30 grams of bisphenol A dimethyl methacrylate in a 100 ml three-necked flask, stir and add 6 grams of hydroxypropyl methacrylate in a constant temperature water bath at 70°C, and keep it for 2 hours after uniformity, then move the flask to room temperature to cool , the viscosity measured by the SDJ-7 rotary viscometer is 12000 centipoise (CPS) / 25°C; second, take 5 ml of acetone, 45 ml of ethanol, and 50 ml of ethyl acetate, add an appropriate amount of flavoring agent and mix evenly Stand-by; the third, get 1 gram of green tea polyphenols and dissolve it in 99 grams of ethanol (95%) for stand-by; get 10 grams of resin prepared in the first step, 80 milliliters of the second-step solution and 10 milliliters of the third-step solution respectively, in Mix evenly in a covered container to obtain a brownish-yellow clear liquid. The measured viscosity is less than 10CPS / 20°C. Take a little of the above-mentioned liquid on a glass slide and flow naturally to form a film. ...

Embodiment 2

[0033] Put 27 grams of bisphenol A dimethyl methacrylate in a 100 ml three-necked flask, stir and add 3 grams of hydroxypropyl methacrylate, heat in a constant temperature water bath at 70°C for 2 hours, then move the flask to room temperature to cool, The viscosity measured by the SDJ-7 rotary viscometer is 25,000 centipoise (CPS) / 25°C; take 10 grams of the above resin and other solutions in the same amount as in the examples, and mix them evenly to obtain a brownish-yellow clear liquid. The measured viscosity is less than 10CPS / 20°C.

Embodiment 3

[0035] 1, get the resin that embodiment 2 prepares.

[0036] 2. Take 55 ml of 95% ethanol, 40 ml of ethyl acetate, and 5 ml of acetone and mix appropriate amount of flavoring agent for use.

[0037] 3. Dissolve 1 gram of green tea polyphenols in 90 grams of ethanol (95%) for later use. Take 10 grams of resin, add 95 milliliters of solution and 5 grams of active solution, and mix evenly to obtain a brownish-yellow clear liquid. The measured viscosity is less than 10CPS / 20°C.

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Abstract

The green tea polyphenol anti-caries coating film of the invention relates to the field of stomatology, especially its formula and process. The green tea polyphenol anti-caries coating film uses green tea polyphenols as an anti-caries material, resin as a film-forming material, solvent and flavoring agent as a flavoring and dispersion material, and green tea polyphenols dispersed in a solvent as an active material. The invention is non-toxic to the body and has no mucosal stimulation to the oral cavity; the green tea polyphenol coating film can adhere stably to the tooth surface, and the residence time is longer, which is beneficial to the release of green tea polyphenols, and the green tea polyphenol coating film can effectively reduce the deciduous teeth of children and the incidence of dental caries in six-year-old teeth. Green tea polyphenol coating can significantly reduce the occurrence of caries in children's deciduous teeth. Compared with similar products, the green tea polyphenol coating film has the advantages of simple operation, convenient coating and good safety.

Description

technical field [0001] The green tea polyphenol anti-caries coating film of the invention relates to the field of stomatology, especially its formula and process. Background technique [0002] At present, the prevention of caries at home and abroad basically adopts two types of methods. The first type is the use of fluoride throughout the body, such as adding fluoride to drinking water, oral fluoride tablets, fluoridated milk, fluoridated salt, etc. However, there are still different views on the safety of fluorine preparations on the human body, especially the use of fluorides. Therefore, the use of such methods must be carried out under the guidance of a doctor. The other is local use of various anti-caries preparations, such as gargles, fluoride toothpaste, anti-caries gel, pit and fissure sealing, etc. Proper use of these methods can effectively reduce the incidence of caries, but there are also limitations in the promotion of use, such as the operation of sealants is ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/05A61K31/353A61P1/02
Inventor 冯希平徐大年刘正刘颖
Owner SHANGHAI SECOND MEDICAL UNIV
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