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Method of thalidomide for effective intervening oral cancer in animal model

A technology of thalidomide and oral cancer, which is applied in the field of vascular inhibitors to intervene in animal models of oral cancer, can solve the problems of lack of data and achieve the effect of moderate experimental time

Inactive Publication Date: 2007-05-23
上海第二医科大学附属第九人民医院
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  • Abstract
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Problems solved by technology

However, there is still a lack of complete data on the effect of the drug on oral cancer

Method used

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  • Method of thalidomide for effective intervening oral cancer in animal model
  • Method of thalidomide for effective intervening oral cancer in animal model
  • Method of thalidomide for effective intervening oral cancer in animal model

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Experimental program
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Effect test

Embodiment 1

[0026] 1. Experimental animals and drugs

[0027] 1. Selection and grouping of experimental animals: 80 male Syrian golden hamsters aged 6-8 weeks, weighing 80-100 grams, clean grade, provided by Shanghai Slack Experimental Animal Co., Ltd. [license number: SCXK (Shanghai) 2002-2003]. Raised in separate cages, 5 per cage, fed with special feed for golden hamsters, and the drinking water was distilled water. They were randomly divided into groups A, B, C, D and E5, with 20 rats in each of groups A, B and C, and 10 rats in each of groups D and E.

[0028] 2. Chemical carcinogens: dimethylbenz(a)anthracene (DMBA) (sigma) and analytically pure acetone solution were prepared into 5 g / L DMBA solution.

[0029] 3. Drugs: The original drug of salvianolic acid B was provided and identified by the Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University. The original drug of thalidomide was provided by Changzhou Pharmaceutical Factory.

[003...

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Abstract

A method for the active interference of thalidomide to animal model of oral cancer includes such steps as creating the animal model of oral cancer, interferring it by thalidomide, histological examination and pathological evaluation. Its advantages are long interference time (12 weeks) and playing the full role of thalidomide.

Description

technical field [0001] The present invention relates to a method for angiostatin to intervene in an animal model of oral cavity cancer, in particular to a method for intervening thalidomide in an animal model of oral cavity cancer. Background technique [0002] Oral cancer is one of the most common malignant tumors of the head and neck. Because of its easy metastasis and poor prognosis, the prevention of oral cancer is particularly important. Cancer chemoprevention has become one of the most promising means to reduce the incidence of oral cancer. In view of the long-term application of cancer chemoprevention drugs, the development of natural plant or food-based drugs is the current direction of cancer chemoprevention. [0003] Promoting blood circulation and removing stasis is one of the basic principles of TCM treatment of tumors. Clinical studies have shown that blood circulation promoting and stasis medicine can improve microcirculation, anticoagulation, inhibit growth...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00
Inventor 周曾同杨娅
Owner 上海第二医科大学附属第九人民医院
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