Pharmaceutical composition for intramuscular injection containing loxoprofen

A composition and injection technology, applied in the field of intramuscular injection preparations, can solve the problems of patch not being fully developed, falling off, restricting movement and discomfort

Inactive Publication Date: 2003-03-05
SHIN POONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, patches have not been fully developed in a large number of studies
In addition, transdermal formulations of loxoprofen must contain many adjuvants such as penetration enhancers, and thus can introduce side effects such as skin rashes
In addition, they can cause discomfort that restricts movement due to being glued to one part of the body for a long time
Specifically, since inflammation or pain may occur at joints, transdermally absorbed patches may have many problems in continuously providing expected pharmacological effects, for example, because they are easily peeled off from the skin due to joint motion

Method used

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  • Pharmaceutical composition for intramuscular injection containing loxoprofen
  • Pharmaceutical composition for intramuscular injection containing loxoprofen

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

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[0032] Preparation of injectable powders

Embodiment 11

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[0038] The plasma concentration of loxoprofen of the intramuscular injection obtained in Example 1 in 6-week-old specific pathogen-free male SD rats was evaluated and compared with commercially available loxoprofen tablets (loxonin: control).

[0039] time

[0040]As described in Table 15 above, since the intramuscular injection was administered at 50% of the dose of the tablet, its drug plasma concentration showed a slightly lower drug plasma concentration than that of the tablet. However, the curves of drug plasma concentration changes between the test and control groups showed very similar ( figure 1 ). Embodiment 2: Stability test of intramuscular injection

Embodiment 2

[0041] stored temperature

[0042] As shown in Table 16 above, the drug content and pH of loxoprofen intramuscular injection remained stable and did not change significantly. Example 3: Comparison of paw edema of loxoprofen in rats between tablet and intramuscular injection

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Abstract

Disclosed is a formulation for intramuscular injection containingloxoprofen or a pharmaceutically acceptable salt thereof, having an excellent anti-inflammatory analgesic effect, as an active ingredient.

Description

technical field [0001] The invention relates to a new pharmaceutical preparation containing loxoprofen. Specifically, the present invention relates to a preparation for intramuscular injection containing loxoprofen or a pharmaceutically acceptable salt thereof as an active ingredient, which has excellent anti-inflammatory and analgesic effects. Background technique [0002] Loxoprofen (chemical name: 2-[4-(2-oxocyclopentane)phenyl]propionic acid) is a propionic acid non-steroidal anti-inflammatory drug (NSAID) and is represented by the following formula: [0003] The above drugs are generally available in the form of the sodium salt, that is to say loxoprofen sodium. [0004] Loxoprofen sodium is effective in the treatment of rheumatoid arthritis, osteoarthritis, lumbosacral strain, adhesive bursitis, and shoulder-brachial-neck syndrome. The drug is also known to be effective in reducing postoperative or post-traumatic pain, or for analgesia after toot...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K9/08A61K9/00A61K9/19A61K31/19A61K31/192A61K47/02A61K47/04A61K47/12A61P29/00
CPCA61K31/192A61K47/02A61K9/0019A61P29/00A61K9/08
Inventor李星泰韩信朴雨逸李哲规金惠善
OwnerSHIN POONG PHARMA CO LTD