Erigeron ester B and its preparation method as well as application in pharmacy

A technology of febrifuga ester B and compound, which is applied in the direction of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve the problem of no new compound patent and so on

Inactive Publication Date: 2003-12-24
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The above disclosures are patents for new uses of known compounds, and there are no patents for new compounds

Method used

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  • Erigeron ester B and its preparation method as well as application in pharmacy
  • Erigeron ester B and its preparation method as well as application in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: the extraction and preparation technology of phyllonidyl ester B

[0046] Get 50kg of the whole herb or above-ground part of Erigeron brevicapus, crush it, and use 70%

[0047] The acetone aqueous solution was extracted three times, and the three extracts were combined and concentrated under reduced pressure. Macroporous resin chromatography on the concentrated solution, eluting with water first, then using 40% ethanol, collecting the 40% ethanol eluent and concentrating under reduced pressure to obtain 800g of the extract, which is repeatedly purified with Sephdex HL-20. B) 150g.

Embodiment 2

[0048] The preparation technology of the tablet of embodiment 2, fenponate B

[0049] Tablet Prescription Feponate B 10g Starch 50g10% Starch Slurry 10g Magnesium Stearate 2g

[0050] After mixing Fipeng ester B and starch evenly, add 10% starch slurry to make soft material, pass through a 14-mesh sieve to granulate, dry at 70-80°C, pass through a 12-mesh sieve for granulation, and add magnesium stearate After mixing, it is pressed into 1000 pieces, that is to say. Each tablet contains 10mg of effective extract.

Embodiment 3

[0051] The capsule preparation technology of embodiment 3, fenponate second

[0052] Capsule prescription Fei Peng ester B 10g starch 50g magnesium stearate 2g

[0053] Add the prescription amount of Fipronate B, add starch and magnesium stearate dried at 80°C, mix evenly, and pack into 1000 capsules, each capsule contains 10mg of extract.

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Abstract

A caffeciate type compound, erigeron ester B, used as the medicine for treating cardiovascular and cerebrovascular diseases is prepared from the dried herb of erigeron breviscapus through extracting and separating.

Description

1. Technical field [0001] The present invention relates to a new compound Erigeroster B which has the activity of treating cardiovascular and cerebrovascular diseases, specifically the new compound Erigeroster B extracted from Erigeron breviscapus, its preparation method and its application in pharmacy Applications. 2. Background technology [0002] The number of cardiovascular and cerebrovascular diseases is increasing day by day, and its serious condition is the first cause of human death. Therefore, its incidence and treatment have also received special attention from the medical community and society. In addition to economic development, the population is aging, and there are many cardiovascular and cerebrovascular diseases in the elderly, which makes the problem more acute. Erigeron breviscapus (Vant.) Hand.-Mazz., also known as Erigeron breviscapus, is the dried whole herb of the genus Erigeron breviscapus (Vant.) Hand.-Mazz. in the family Asteraceae. For the first t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/35A61K31/7028A61P9/10C07D493/08C07H15/18
Inventor 赵勤实孙汉董彭丽艳
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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