Combinations of inhibin with bronchodilators

A technology of bronchodilators and statins, applied in drug combinations, antipyretics, pharmaceutical formulations, etc., can solve problems such as systemic inflammation that has not been optimized

Inactive Publication Date: 2007-06-20
ASTRAZENECA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, anti-inflammatory drugs currently developed for the signs and symptoms of specific diseases may not be optimized for the long-term treatment of concurrent systemic inflammation, which is postulated to be the cause of many common pathologies

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Example 1 - Inhalation - Dry Powder

[0084] INGREDIENTS PER DOSAGE

[0085] Formoterol (as fumarate dihydrate) 4.5 μg

[0086] Budesonide 160μg

[0087] Rosuvastatin 1mg

Embodiment 2

[0088] Example 2 - Inhalation - Metered dose inhaler

[0089] INGREDIENTS PER DOSAGE

[0090] Formoterol (as fumarate dihydrate) 4.5 μg

[0091] Budesonide 160μg

[0092] Rosuvastatin 1mg

[0093] HFA227 50μl

Embodiment 3

[0094] Example 3 - Inhalation - Dry Powder

[0095] INGREDIENTS PER DOSAGE

[0096] Formoterol (as fumarate dihydrate) 4.5 μg

[0097] Budesonide 160μg

[0098] Rosuvastatin 1mg

[0099] Lactose up to 1, 2, 5, 10 or 20mg

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PUM

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Abstract

The invention provides medicaments comprising combinations of bronchodilators, glucocorticosteroids and HMG-CoA reductase inhibitors in the treatment of respiratory disorders such as chronic obstructive pulmonary disease (COPD).

Description

technical field [0001] The present invention provides medicaments for the treatment of respiratory diseases such as chronic obstructive pulmonary disease (COPD) comprising combinations of bronchodilators, glucocorticosteroids and HMG-CoA reductase inhibitors. Background technique [0002] The diagnosis and treatment of many diseases focus, for obvious reasons, on the typical criteria and manifestations that are characteristic of a particular disease (thereby distinguishing it from other diseases). Examples are joint-related signs and symptoms in rheumatoid arthritis (RA), and lung function tests in COPD. [0003] But many diseases have significant co-morbidity, and they are often considered "other" diseases because they are not unique to or specific to the primary disease. For example, cardiovascular co-morbidities may often be considered indeterminate and not directly related to primary diseases such as RA or COPD. However, co-morbidities can be as important as regular ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/40A61K31/505A61K31/58A61K31/165A61P11/00A61P11/06A61P11/08
CPCA61K31/505A61K31/165A61K31/58A61K45/06A61K31/40A61P11/00A61P11/06A61P11/08A61P19/02A61P29/00A61P43/00A61K2300/00
Inventor 伯蒂尔·林德马克安德斯·I·索伦
Owner ASTRAZENECA AB
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