Treatment of alcohol abuse and alcoholism using modulators of neurosteroid binding sites on gabaa receptors

a technology of neurosteroid binding site and gabaa receptor, which is applied in the field of treatment of alcohol abuse and acute alcohol poisoning in humans, can solve the problems of ineffective treatment in many patients, off-target toxicity, etc., and achieve the effect of reducing alcohol drinking behavior

Inactive Publication Date: 2011-04-14
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIV & AGRI & MECHANICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

The current drugs on the market (e.g., opiate antagonists and acetaldehyde inhibitors such as disulfram) exhibit certain unwanted adverse effects and non-targeted or off-target toxicity, rendering them ineffective in many patients.

Method used

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  • Treatment of alcohol abuse and alcoholism using modulators of neurosteroid binding sites on gabaa receptors
  • Treatment of alcohol abuse and alcoholism using modulators of neurosteroid binding sites on gabaa receptors
  • Treatment of alcohol abuse and alcoholism using modulators of neurosteroid binding sites on gabaa receptors

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Embodiment Construction

[0016]The present invention provides methods for reducing alcohol drinking behavior in humans exhibiting alcoholism and for treating acute alcohol poisoning. The agents utilized in the methods of the invention are neutral or negative modulators of the neurosteroid sites on GABAA receptors. These agents avoid the unwanted side-effects of opiate antagonists and display specificity toward the neurosteroid binding sites on GABAA receptors.

[0017]It is noted that the administration of certain neuroactive steroids to humans may provide benefits to those with certain psychiatric disorders, such as stress disorders, anxiety disorders, and depression. See U.S. Patent Application Publication No. 2008 / 0070879 A1, which is hereby incorporated by reference.

[0018]According to an exemplary though non-limiting embodiment of the present invention, a method for therapeutic treatment of alcoholism may comprise administration of a modulating agent that demonstrates specificity to neurosteroid binding si...

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Abstract

The present invention provides methods for reducing alcohol drinking behavior in humans and treating acute alcohol poisoning through the use of neutral or negative modulating agents of the neurosteroid sites on GABAA receptors. These agents avoid the unwanted side-effects of opiate antagonists and displays specificity toward the neurosteroid binding sites on GABAA receptors.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application claims the benefit of prior U.S. Provisional Application No. 61 / 278,424, filed Oct. 7, 2009, which is hereby incorporated by reference.FIELD OF THE INVENTION[0002]The present invention relates generally to methods for the treatment of alcoholism and acute alcohol poisoning in humans, and in particular, to methods for the treatment of alcoholism and acute alcohol poisoning in humans through the administration of neutral or negative modulating agents of neurosteroid binding sites on GABAA receptors.BACKGROUND[0003]On an international scale, the World Health Organization estimates that alcohol dependence is the third leading cause of disease in developing countries worldwide. Alcohol use disorders, including alcohol abuse and dependence, affect seven to eight percent of Americans (about 15 to 20 million adults) at any given time. Accordingly, in the United States alone alcohol use disorders account for roughly $185 bi...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/5685A61K31/56A61P25/32
CPCA61K31/5685A61K31/56A61P25/32
Inventor WINSAUER, PETER
Owner BOARD OF SUPERVISORS OF LOUISIANA STATE UNIV & AGRI & MECHANICAL COLLEGE
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