Light collection system

a light collection and light source technology, applied in the field of biological sample detection methods and systems, can solve the problems of adding complexity and size to the detection system of external light sources and associated optical components

Inactive Publication Date: 2012-11-08
LIFE TECH CORP
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This approach reduces light loss and simplifies the detection system by allowing for efficient collection and detection of luminescent light emitted from the biological sample within the container, providing a compact and effective means of biological sample analysis.

Problems solved by technology

External light source and associated optical components add complexity and size to detection systems.

Method used

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[0081]FIGS. 8 and 9 show the results of an example of a detection cell for biological material. A 2.5 microliter luminescent reaction was set up containing 2×10-13 moles of pyrophosphate, ATP sulfurlase, adenosine-5′-O-phosphosulfate and luciferase. The reaction was combined in a tube and then introduced into a glass capillary (0.4 mm inside diameter, 0.86 outside diameter, 15 mm in length). Light intensity produced by the reaction was quantified using a Turner TD 20 / 20 luminometer. Luminescence was measured from five different orientations of the capillary using the same capillary and reaction. Each of the measurements were taking over 25 seconds. FIG. 8 shows the results of intensity over time. The five data sets for the five orientations resulted in line 810 representing light from capillary wall and ends, line 830 representing light from one end of the capillary, line 840 representing light from the capillary wall only (ends taped with black tape), line 820 representing light fr...

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Abstract

The present teachings provide a detection cell for a biological material and methods for detecting biological material including a photosensitive material optically coupled to an interior volume containing the biological material so to avoid optical components or an external light source.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims a priority benefit under 35 USC §119(e) from U.S. Patent Application No. 60 / 626,784 filed Nov. 9, 2004, which is incorporated herein by reference.FIELD[0002]The present teaching relate to methods and systems for detection of biological samples.INTRODUCTION[0003]Detection of results from assays on biological samples is usually done by detection of emission light from the biological samples. Typically, excitation light is provided by an external light source to excite a moiety of the biological sample to provide emission light. The direction of excitation light to the biological sample from the external light source and the direction of emission light to a detector from the biological sample require optical components to direct the light, such as lenses, mirrors, gratings, prisms, etc. External light source and associated optical components add complexity and size to detection systems. It is desirable to select assay...

Claims

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Application Information

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Patent Type & AuthorityApplications(United States)
IPC IPC(8): C12M1/34G01N21/76
CPCG01N21/6428G01N21/645G01N21/66G01N21/763G01N2021/6469C12Q1/66G01N33/581G01N2021/6439
InventorBAHATT, DARFAULSTICH, KONRAD
OwnerLIFE TECH CORP