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Drug delivery system

a delivery system and encapsulation technology, applied in the direction of chewing gum, pharmaceutical product form change, drug composition, etc., can solve the problems of large amount of time, complex encapsulation methods, heat and moisture in order to properly form the encapsulated final product,

Inactive Publication Date: 2013-01-24
CAPRICORN PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The inventive method described in this patent does not require heat or moisture to create the encapsulated product. This allows for high levels of active ingredients to be included in the product. Additionally, the encapsulated product has a consistent amount of active ingredients and is strong enough to withstand pressure during processing and chewing in the mouth. This ensures that the active ingredients are released in the stomach.

Problems solved by technology

There are a number of disadvantages when using the traditional encapsulation processes to encapsulate active ingredients.
The disadvantages include the need for heat and moisture in order to properly form the encapsulated final product.
Also, most encapsulation methods are complex and consume large amounts of time in order to obtain the final encapsulated product.
Further, current encapsulated ingredients vary in size from nanometers to about 400 microns, and the active ingredients are not uniformly distributed throughout the encapsulated product.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of Encapsulated Product Containing Dimenhydrinate

[0095]The encapsulated product according to the present inventive subject matter may be made by the following process.

[0096]43.5 grams of dimenhydrinate is mixed into 51.3 grams of compressible sucrose to form a mixture. The mixture is then granulated using 3.9 grams of povidone k30, a binder. After mixing with the binder, the material is passed through a no. 10 mesh and allowed to air dry. The dried material is then passed through a no. 20 mesh and mixed with 1.3 grams of magnesium stearate. The final mixture is mixed for 3 minutes. The mixture is loaded into a tableting machine.

[0097]A series of caplets 3 millimeters in length and 3 millimeters in diameter is produced using 20 KN of force. The punch is then changed in the tableting machine and a series of caplets 1.3 millimeters in length and 1.3 millimeters in diameter is produced using 20 KN of force.

example 2

Preparation of Encapsulated Product Containing Nifedipine

[0098]The encapsulated product according to the present inventive subject matter may be made by the following process.

[0099]34.1 grams of nifedipine is mixed into 51.7 grams of compressible sucrose to form a mixture. The mixture is then granulated using 4.2 grams of plasdone k-29 / 32, a binder. After mixing with the binder, the material is passed through a no. 10 mesh and allowed to air dry. The dried material is then passed through a no. 20 mesh and mixed with 1.0 grams of magnesium stearate. The final mixture is mixed for 3 minutes. The mixture is loaded into a tableting machine.

[0100]A series of caplets 3 millimeters in length and 3 millimeters in diameter is produced using 20 KN of force. The punch is then changed in the tableting machine and a series of caplets 1.3 millimeters in length and 1.3 millimeters in diameter is produced using 20 KN of force.

example 3

Preparation of Encapsulated Product Containing Nifedipine

[0101]The encapsulated product according to the present inventive subject matter may be made by the following process.

[0102]34.1 grams of nifedipine is mixed into 60.0 grams of compressible sucrose to form a mixture. The mixture is then granulated using 5.0 grams of plasdone k-29 / 32, a binder. After mixing with the binder, the material is passed through a no. 10 mesh and allowed to air dry. The dried material is then passed through a no. 20 mesh and mixed with 1.0 grams of magnesium stearate. The final mixture is mixed for 3 minutes. The mixture is loaded into a tableting machine.

[0103]A series of caplets 3 millimeters in length and 3 millimeters in diameter is produced using 20 KN of force. The punch is then changed in the tableting machine and a series of caplets 1.3 millimeters in length and 1.3 millimeters in diameter is produced using 20 KN of force.

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Abstract

A novel encapsulated product is provided and includes: at least one pharmaceutical; at least one compressible material; and at least one tableting material; wherein the encapsulated product is in the form of a caplet having a diameter of from about 1 millimeter to about 7 millimeters and a length from about 1 millimeter to about 7 millimeters. A method for preparing the encapsulated product is also provided.

Description

RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 09 / 920,093, filed Oct. 19, 2001, which is a continuation- in-part of Provisional Application No. 60 / 308,568, filed Jul. 31, 2001, which is a continuation-in- part of application Ser. No. 09 / 587,971, filed Jun. 6, 2000, now U.S. Pat. No. 6,555,145 that issued on Apr. 29, 3003, the entire contents of all which are incorporated herein by reference in their entirety.FIELD OF THE INVENTION[0002]The present invention relates to an encapsulation process, and in particular, an alternate encapsulation process for concentrating pharmaceuticals using compression.DESCRIPTION OF THE PRIOR ART[0003]Various types of chewable articles are known in commerce. These articles include food items such as food items, confectionery items and chewing gum. The chewable articles often include various types of active agents or ingredients within the chewable articles. Examples of such active ingredients include fla...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61P31/00A61J3/10A61P25/18A61P9/00A61K9/00A61P1/00A21D13/08A23G3/00A23G3/54A23G4/00A23G4/20A23L2/395A23L27/00
CPCA21D13/08A23G3/54A23L2/395A23L1/22016A23G4/20A23L27/72A21D13/80A61P1/00A61P25/18A61P31/00A61P9/00
Inventor CHERUKURI, S. RAO
Owner CAPRICORN PHARMA INC