Unlock instant, AI-driven research and patent intelligence for your innovation.

Method for determining glucose concentration in human blood

Inactive Publication Date: 2015-03-12
HEALBE
View PDF1 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a method for measuring blood glucose concentration in humans using electrodes attached to the body. The method involves measuring the volume of fluid in the body region between the electrodes at different times and using these measurements to calculate the concentration of glucose in the blood. The method is non-invasive and can be used to monitor glucose levels in real-time. The measured volume of fluid is used to estimate the concentration of glucose in the blood by measuring the change in osmotic pressure caused by the movement of water in response to changes in the concentration of solids dissolved in it. The method is based on the principle that changes in water spaces in the body are caused by metabolic processes and can be used as indicators of the character of these processes. The method can be used to monitor glucose levels in humans during different stages of life activity, such as food intake.

Problems solved by technology

However, the above-described methods are characterized by one common disadvantage—namely, the values of glucose concentration in human blood obtained through the use of these methods rank below the values obtained using direct invasive methods in terms of measurement accuracy.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for determining glucose concentration in human blood
  • Method for determining glucose concentration in human blood
  • Method for determining glucose concentration in human blood

Examples

Experimental program
Comparison scheme
Effect test

example 1

Processing of Measurement Data for Healthy Volunteer #1

[0093]A 38-year-old healthy male, took a meal (food load) of 300 g of sweet beverage (Pepsi Cola). FIG. 1b shows the graphs of impedance value variation ZHF and ZLF and temperature T° C. recorded by the sensor located on the forearm, while FIG. 1a shows the graph of variation of glucose concentration in the blood of Volunteer #1. Dots indicate values of blood sample taken during the measurements (Roche Accu-Chek Active glucometer was used). The mean error for the measurement interval of 150 minutes was equal to 6.8%.

example 2

Processing of Measurement Data for Healthy Volunteer #2

[0094]A 45-year-old healthy male, took a meal (food load) of two 200 g glasses of sweet beverage (Pepsi Cola). FIG. 2b shows the graphs of impedance value variation ZHF and ZLF and temperature T° C. recorded by the sensor located on the forearm, while FIG. 2a shows the graph of variation of glucose concentration in the blood of Volunteer #2. Dots indicate values of blood sample taken during the measurements (Roche Accu-Chek Active glucometer was used). The mean error for the measurement interval of 140 minutes was equal to 7.2%.

example 3

Processing of Measurement Data for Healthy Volunteer #3

[0095]A 42-year-old healthy male, took a combined meal (food load) of 200 g of sweet beverage (Pepsi Cola) and banana. FIG. 3b shows the graphs of impedance value variation ZHF and ZLF and temperature T° C. recorded by the sensor located on the forearm, while FIG. 3a shows the graph of variation of glucose concentration in the blood of Volunteer #3. Dots indicate values of blood sample taken during the measurements (Roche Accu-Chek Active glucometer was used). The mean error for the measurement interval of 150 minutes was equal to 9.5%.

[0096]The conducted tests showed that the method claimed herein is characterized by lesser error when determining the value of glucose concentration in human blood as compared to the known non-invasive methods.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Measuring the impedance of a human body region at a high frequency (ZHF) and a low frequency (ZLF). ZHF is used to obtain the value of the volume of fluid in the tissues of the region. ZLF is used to obtain the value of the volume of extracellular fluid in the tissues. The increase in the metabolic component in the volume of extracellular fluid is determined by the increase of the volume of all of the fluid in comparison with the previous measurement, determining the increase in the volume of extracellular fluid in comparison with the previous measurement and subsequently calculating the difference between the increases in the volume of all of the fluid and the volume of extracellular fluid. The glucose concentration G(tk) is determined by adding the amount of increase in the glucose concentration and the value of the glucose concentration determined at the previous measuring stage.

Description

RELATED APPLICATIONS[0001]This Application is a Continuation application of International Application PCT / RU2013 / 000144, filed on Feb. 22, 2013, which in turn claims priority to Russian Patent Applications No. RU2012106461, filed Feb. 24, 2012, both of which are incorporated herein by reference in their entirety.FIELD OF THE INVENTION[0002]The invention refers to non-surgical methods for medical examination of human health, namely, to methods for determining glucose concentration in human blood as a result of measuring the impedance of human body part.BACKGROUND OF THE INVENTION[0003]Non-invasive methods for determining glucose concentration in human blood based on measuring the electrical impedance of a human body part or impedance components are known.[0004]For example, a method for the indication of sugar content in human blood is known [RU Pat. No. 2073242, G01N33 / 4, 1997], with which sugar content level is determined based on variation of dielectric permeability of a finger pla...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61B5/145G01N27/02A61B5/0531
CPCG01N27/02A61B5/14532A61B5/053A61B5/0537A61B5/1473A61B5/25
Inventor SOKOLOV, EVGENIY L.CHECHIK, ANDREY A.ELOKHOVSKIY, VLADIMIR Y.
Owner HEALBE