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Treatment of Irritable Bowel Syndrome

a technology of irritable bowel syndrome and tapentadol, which is applied in the field of tapentadol, can solve the problems of insufficient knowledge of the cost of ibs to society is substantial, and the pathophysiology of ibs is complex, so as to increase the amount of tapentadol, avoid side effects, and avoid side effects

Inactive Publication Date: 2017-02-16
GRUNENTHAL GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text explains the advantages of using low doses of tapentadol in medications to avoid side effects. The preferred dosage range is 0.001 to 99.9999%, with 0.01 to 99.999% being more ideal. To minimize side effects, it may be beneficial to gradually increase the amount of tapentadol given to the body. The medication is first administered at a low dose to allow the body to become accustomed to the active substance slowly. This approach is especially important when starting treatment with tapentadol because it has a higher potential for causing side effects than other pain medications.

Problems solved by technology

Due to its high prevalence and, for many patients, chronic nature and incapacitating symptoms the cost of IBS to society is substantial.
The pathophysiology of IBS is complex and still incompletely known.
Due to the limited efficacy and tolerability of current treatment, there is still a great need to find new treatment alternatives for this big patients group.

Method used

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  • Treatment of Irritable Bowel Syndrome
  • Treatment of Irritable Bowel Syndrome
  • Treatment of Irritable Bowel Syndrome

Examples

Experimental program
Comparison scheme
Effect test

examples

1. Effects of Tapentadol on the Twitch Contractions of the Isolated Guinea Pig Ileum

[0059]It was investigated whether tapentadol is able to modulate gastrointestinal motility. For this purpose, the responses to the compound were tested on electrically induced contractions of guinea pig ileum (so called Twitch reactions), which are known to be reduced e.g. by opioids (Paton, W D M. (1957) The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. Br. J. Pharmacol. Chemother. 11: 119-127).

1.1 Experimental Animals

[0060]Male guinea pigs (PBW, Charles River, Kiβlegg, FRG) weighing 250-350 g were used for the study. The animals were kept under standard housing conditions: light / dark rhythm (06.00-18.00 h light, 18.00-6.00 h dark); room temperature 22±2° C., rel. air humidity 55±5%; 15 air changes per hour, air movement <0.2 m / sec. The animals were given water and an exclusive diet of “Herilan RM 204” (Eggersmann Compa...

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Abstract

A method of treating irritable bowel syndrome in a patient in need thereof by administering to said patient a pharmaceutically effective amount of tapentadol.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a division of co-pending application Ser. No. 13 / 172,103, filed Jun. 29, 2011. Priority is claimed based on U.S. provisional patent application No. 61 / 360,191, and European patent application no. EP 10 006 782.6, each filed Jun. 30, 2010.BACKGROUND OF THE INVENTION[0002]The invention relates to tapentadol for use in the treatment of irritable bowel syndrome. Irritable bowel syndrome (IBS or spastic colon) is characterized by abdominal pain and / or discomfort related to abnormal bowel habits. It is probably the most common disorder encountered by gastroenterologists and also the most common gastrointestinal disorder seen in primary care. In the Western world, IBS appears to affect up to 20% of the population at any given time, although the prevalence figures vary substantially depending on the definition of IBS (Posserud I, Ersryd A, Simrén M, Functional findings in irritable bowel syndrome. World J. Gastroenterol. 2006;...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/137A61K9/20A61K9/00
CPCA61K31/137A61K9/20A61K9/0053A61K31/135A61P1/00A61P1/04A61P1/06A61P1/10A61P1/12
Inventor SCHIENE, KLAUSBLOMS-FUNKE, PETRACHRISTOPH, THOMASSCHROEDER, WOLFGANG
Owner GRUNENTHAL GMBH