Constructs targeting afp peptide/mhc complexes and uses thereof

a technology of afp protein and complex, which is applied in the field of constructs targeting afp protein/mhc complex, can solve the problems of patients relapse, antibody directed against afp protein has little therapeutic effect, and the target of afp protein has not been a very active area for anti-cancer antibody developmen

Inactive Publication Date: 2018-07-26
EUREKA THERAPEUTICS INC
View PDF1 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because AFP is not a cell-surface protein, targeting AFP has not been a very active area for anti-cancer antibody drug development.
Non-surgical treatments, such as trans-arterial chemoembolization (TACE / TAE), radio-frequency ablation and systemic targeted agent like sorafenib, have been shown to reduce tumor burden and improve survival rate but these treatments do not eradicate cancer cells and the patients frequently relapse.
Antibodies directed against the AFP protein have little therapeutic efficacy since AFP is not a cell-surface protein, and may be present at high circulating levels, thus reducing any specific targeting of the antibody to the cells expressing AFP.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Constructs targeting afp peptide/mhc complexes and uses thereof
  • Constructs targeting afp peptide/mhc complexes and uses thereof
  • Constructs targeting afp peptide/mhc complexes and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

embodiment 1

[0518]In some embodiments, there is provided an isolated anti-AMC construct comprising an antibody moiety that specifically binds to a complex comprising an alpha-fetoprotein (AFP) peptide and a major histocompatibility (MHC) class I protein (an AFP / MHC class I complex, or AMC).

embodiment 2

[0519]In some further embodiments of embodiment 1, the AFP / MHC class I complex is present on a cell surface.

embodiment 3

[0520]In some further embodiments of embodiment 1, the AFP / MHC class I complex is present on the surface of a cancer cell.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
equilibrium dissociation constantaaaaaaaaaa
equilibrium dissociation constantaaaaaaaaaa
Login to view more

Abstract

The present application provides constructs comprising an antibody moiety that specifically binds to a complex comprising an AFP peptide and an MHC class I protein. Also provided are methods of making and using these constructs.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Application No. 62 / 142,958, filed on Apr. 3, 2015, U.S. Provisional Application No. 62 / 244,653, filed on Oct. 21, 2015, and U.S. Provisional Application No. 62 / 304,915, filed on Mar. 7, 2016, all of which are hereby incorporated by reference in their entireties.FIELD OF THE INVENTION[0002]This invention pertains to antibody constructs that specifically bind MHC molecules complexed with AFP peptides, and uses thereof including treating and diagnosing diseases.SUBMISSION OF SEQUENCE LISTING ON ASCII TEXT FILE[0003]The content of the following submission on ASCII text file is incorporated herein by reference in its entirety: a computer readable form (CRF) of the Sequence Listing (file name: 750042000140SEQLIST.txt, date recorded: Apr. 1, 2016, size: 65 KB).BACKGROUND OF THE INVENTION[0004]Cell surface proteins constitute only a small fraction of the cellular proteins and these proteins are...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(United States)
IPC IPC(8): C07K16/28A61K39/395C07K14/725C07K14/705C07K16/30
CPCC07K16/2809A61K39/395C07K14/7051C07K14/70596C07K16/2833C07K16/303A61K2039/54C07K2317/21C07K2317/31C07K2317/33C07K2317/34C07K2317/565C07K2317/622C07K2317/734C07K2317/92C07K2319/02C07K2319/03C07K16/30C07K14/4715C07K14/70539C12N5/0636A61K47/6801A61K47/6851A61K47/6849A61K39/001181A61K39/001114A61P35/00A61P1/16A61P15/00A61P35/04C07K2317/56C07K2319/33C12N2510/00A61K2039/5156A61K2039/5158A61K39/00C07K16/18C07K2319/00A61K38/00A61K39/0011A61K2039/505
Inventor LIU, CHENGLIU, HONGXU, YIYANGXIANG, JINGYILONG, LI
Owner EUREKA THERAPEUTICS INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products