Constructs targeting afp peptide/mhc complexes and uses thereof
a technology of afp protein and complex, which is applied in the field of constructs targeting afp protein/mhc complex, can solve the problems of patients relapse, antibody directed against afp protein has little therapeutic effect, and the target of afp protein has not been a very active area for anti-cancer antibody developmen
Inactive Publication Date: 2018-07-26
EUREKA THERAPEUTICS INC
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Problems solved by technology
However, because AFP is not a cell-surface protein, targeting AFP has not been a very active area for anti-cancer antibody drug development.
Non-surgical treatments, such as trans-arterial chemoembolization (TACE / TAE), radio-frequency ablation and systemic targeted agent like sorafenib, have been shown to reduce tumor burden and improve survival rate but these treatments do not eradicate cancer cells and the patients frequently relapse.
Antibodies directed against the AFP protein have little therapeutic efficacy since AFP is not a cell-surface protein, and may be present at high circulating levels, thus reducing any specific targeting of the antibody to the cells expressing AFP.
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embodiment 1
[0518]In some embodiments, there is provided an isolated anti-AMC construct comprising an antibody moiety that specifically binds to a complex comprising an alpha-fetoprotein (AFP) peptide and a major histocompatibility (MHC) class I protein (an AFP / MHC class I complex, or AMC).
embodiment 2
[0519]In some further embodiments of embodiment 1, the AFP / MHC class I complex is present on a cell surface.
embodiment 3
[0520]In some further embodiments of embodiment 1, the AFP / MHC class I complex is present on the surface of a cancer cell.
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Abstract
The present application provides constructs comprising an antibody moiety that specifically binds to a complex comprising an AFP peptide and an MHC class I protein. Also provided are methods of making and using these constructs.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Application No. 62 / 142,958, filed on Apr. 3, 2015, U.S. Provisional Application No. 62 / 244,653, filed on Oct. 21, 2015, and U.S. Provisional Application No. 62 / 304,915, filed on Mar. 7, 2016, all of which are hereby incorporated by reference in their entireties.FIELD OF THE INVENTION[0002]This invention pertains to antibody constructs that specifically bind MHC molecules complexed with AFP peptides, and uses thereof including treating and diagnosing diseases.SUBMISSION OF SEQUENCE LISTING ON ASCII TEXT FILE[0003]The content of the following submission on ASCII text file is incorporated herein by reference in its entirety: a computer readable form (CRF) of the Sequence Listing (file name: 750042000140SEQLIST.txt, date recorded: Apr. 1, 2016, size: 65 KB).BACKGROUND OF THE INVENTION[0004]Cell surface proteins constitute only a small fraction of the cellular proteins and these proteins are...
Claims
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Patent Type & Authority Applications(United States)
IPC IPC(8): C07K16/28A61K39/395C07K14/725C07K14/705C07K16/30
CPCC07K16/2809A61K39/395C07K14/7051C07K14/70596C07K16/2833C07K16/303A61K2039/54C07K2317/21C07K2317/31C07K2317/33C07K2317/34C07K2317/565C07K2317/622C07K2317/734C07K2317/92C07K2319/02C07K2319/03C07K16/30C07K14/4715C07K14/70539C12N5/0636A61K47/6801A61K47/6851A61K47/6849A61K39/001181A61K39/001114A61P35/00A61P1/16A61P15/00A61P35/04C07K2317/56C07K2319/33C12N2510/00A61K2039/5156A61K2039/5158A61K39/00C07K16/18C07K2319/00A61K38/00A61K39/0011A61K2039/505
Inventor LIU, CHENGLIU, HONGXU, YIYANGXIANG, JINGYILONG, LI
Owner EUREKA THERAPEUTICS INC
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