Susceptibility gene for Alzheimer's disease
a gene and susceptibility technology, applied in the field of gene susceptibility to alzheimer's disease, can solve the problems of alzheimer's disease patients being more prone to certain types of cancer, and becoming a major health problem in the western world
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Genotyping of p21cip 1 Polymorphisms
Patient Population
[0044]The subjects tested were full participants in the Oxford Project to Investigate Memory and Ageing (OPTIMA). The yearly routine OPTIMA examination includes a physical examination, cognitive and neuropsychological testing. Drug intake and any intercurrent infections are recorded.
Materials and Methods
Exon 2 of p21cip was amplified from genomic DNA (extracted from brain or blood) using primers 5′-CGGGATCCGGCGCCATGTCAGAACCGGC-3′ (SEQ ID NO: 1) and 5′-CCAGACAGGTCAGCCCTTGG-3′ (SEQ ID NO: 2) (Facher, E. A., et al., Association between human cancer and two polymorphisms occurring together in the p21Waf1 / Cip1 cyclin-dependent kinase inhibitor gene. Cancer, 1997. 79(12): p. 2424-9). PCR amplification was carried out in a final volume of 50 μl using 1.25 units of Tag DNA polymerase, 1.5 mM MgCl2, 0.1% Gelatine, 200 μM of each DNTP in PCR buffer (75 mM Tris-HCl, pH 8.8, 20 mM (NH4)2SO4 and 0.01% Tween). The hot start (95° C. for 5′) was...
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