Nano medicament containing oregano oil and vitamins

A nano-drug and vitamin technology, which is applied to medical preparations containing active ingredients, drug combinations, and non-active ingredients medical preparations, etc., can solve the problems such as bacteria breeding in drinking fountains, low bioavailability, and clogging of drinking fountains. Achieve uniform intake, high bioavailability, and rapid exposure to animals

CN101530466BInactive Publication Date: 2012-05-09NORTHWEST A & F UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2012-05-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a nano medicament containing oregano oil and vitamins. The grain diameter of the nano medicament is between 1 and 100 nm, and the nano medicament consists of the following compositions by mass percentage: 0.002 to 10 percent of the oregano oil, 0.00054 to 2.7 percent of vitamin A oil, 0.00008 to 0.4 percent of vitamin D3 oil, 0.001 to 5 percent of vitamin E oil, 0.00005 to0.25 percent of vitamin K3, 0.001 to 15 percent of water-soluble vitamin, 0.001 to 5 percent of isopropyl myristate, 0.025 to 50.015 percent of surfactant, 0.003 to 15 percent of cosurfactant and 19.98 to 99.98 percent of distilled water. The medicament is mainly used for preventing and controlling alimentary bacteriosis of beasts and birds, supplementing deficiency of vitamins in vivo of animals, promoting metabolism, improving alimentation, improving feeder conversion rate, promoting growth and weight increment, and improving the immunity of organisms.
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Description

technical field

[0001] The invention belongs to the field of veterinary medicine, and relates to a method for preventing and treating bacterial diseases of the digestive tract of livestock and poultry caused by Escherichia coli, Salmonella and Staphylococcus aureus, supplementing the deficiency of vitamins in animals, maintaining normal physiological functions of animals, and promoting metabolism. The medicine for promoting food intake, improving nutrient absorption, improving feed conversion rate, promoting growth and weight gain, and improving body immunity specifically relates to a nano-medicine containing oregano oil and vitamins used by livestock and poultry. Background technique

[0002] Oregano oil (Oregano oil) is a volatile essential oil extracted from the plant oregano, and its main components are carvacrol, thymol, thymol, lithioquinone, dipentene, and karokiol and carvacrol etc. Oregano oil is a pharmaceutical feed additive approved by the Ministry of Agricultur...

Examples

Embodiment 1

[0073] 1) The preparation method of oregano oil nanoemulsion: under normal temperature and pressure, after mixing 5g oregano oil, 2.5g isopropyl myristate, 25g Tween-80, and 7.5g ethanol, stir evenly, and slowly pour into it Add 10g of distilled water and stir while adding to form oregano oil nanoemulsion;

[0074] 2) The preparation method of vitamin nanoemulsion: under normal temperature and pressure, 0.54g vitamin A oil, 0.08g vitamin D 3 Oil, 1g vitamin E oil and 4.86g Tween-80 were mixed, homogenized for 30min, and then slowly added dropwise 3 , 0.18g thiamine, 0.72g riboflavin, 0.3g pyridoxine, 0.0009g vitamin B 12 , 1g of calcium pantothenate, 2.7g of nicotinamide, and 0.015g of biotin in 38.55g of distilled water. Stir while adding. At the beginning, the viscosity of the system is small. With the addition of water, the system will become viscous. Continue to add dropwise and keep stirring. After the amount of water reaches a certain value, the system will become thin...

Embodiment 2

[0078] 1) The preparation method of oregano oil nanoemulsion: under normal temperature and pressure, after mixing 5g oregano oil, 2.5g isopropyl myristate, 25g Tween-80, and 7.5g propylene glycol, stir evenly, and slowly pour into it Add 10g of distilled water and stir while adding to form oregano oil nanoemulsion;

[0079] 2) The preparation method of vitamin nanoemulsion: under normal temperature and pressure, 0.54g vitamin A oil, 0.08g vitamin D 3 Oil, 1g vitamin E oil and 4.86g Tween-80 were mixed, homogenized for 30min, and then slowly added dropwise 3 , 0.18g thiamine, 0.72g riboflavin, 0.3g pyridoxine, 0.0009g vitamin B 12 , 1g of calcium pantothenate, 2.7g of nicotinamide, and 0.015g of biotin in 38.55g of distilled water. Stir while adding. At the beginning, the viscosity of the system is small. With the addition of water, the system will become viscous. Continue to add dropwise and keep stirring. After the amount of water reaches a certain value, the system will be...

Embodiment 3

[0083] 1) The preparation method of oregano oil nanoemulsion: under normal temperature and pressure, after mixing 5g oregano oil, 2.5g isopropyl myristate, 25g Tween-80, and 7.5g ethanol, stir evenly, and slowly pour into it Add 10g of distilled water and stir while adding to form oregano oil nanoemulsion;

[0084] 2) The preparation method of vitamin nanoemulsion: under normal temperature and pressure, 1.35g vitamin A oil, 0.2g vitamin D 3 Oil, 2.5g vitamin E oil and 12.15g Tween-80 were mixed, homogenized for 30min, and then slowly added dropwise to it containing 0.125g vitamin K 3 Add 33.675g of distilled water and stir while adding. At the beginning, the viscosity of the system is small. With the addition of water, the system will become viscous. Continue to add dropwise and stir continuously. When the amount of water reaches a certain value, the system will become thinner again. Then add enough water to form vitamin nanoemulsion;

[0085] 3) After mixing the oregano oil...