Method for preparing polymer liquid crystal membrane material with biomimic structure and use of material

Abstract

The invention belongs to the field of biomedical materials and particularly relates to a method for preparing a polymer liquid crystal membrane material with a biomimic structure and a use of the material. The method for preparing the polymer liquid crystal membrane material with the biomimic structure comprises the following steps: coating the polymer liquid crystal material in liquid crystal state under a physiological temperature by a solution method to form a film, immersing into the water solution of the vinyl monomer containing choline phosphate and a polymerization inhibitor to immerse, and co-radiating by <60>Co-gamma ray or electron beam to perform grafting reaction to obtain the polymer liquid crystal membrane material with the biomimic structure. The method is simple in process, low in cost, short in production period and excellent in industrial application future, the effects of energy saving and emission reduction are realized by using a civil nuclear technology, and the environment pollution is reduced; while obtaining the polymer liquid crystal membrane material with the biomimic structure, the molecular structure and the aggregation structure of the cell membrane are simultaneously simulated, and the material is excellent in surface biological property and is widely used in the fields such as the surgical dressing, the interventional implantation instrument and the medical instrument contacted with the blood.

Description

technical field

[0001] The invention belongs to the field of biomedical materials, and in particular relates to the preparation and application of a polymer liquid crystal membrane material imitating a cell membrane structure. Background technique

[0002] With the development of biomedicine, the application of biomaterials has become more and more extensive and important, and the key performance of biomaterials is their biocompatibility. Since biomedical materials often need to be in contact with the human body surface, blood, and body fluids, and some even require permanent implantation in the body, in order to ensure the safety of their use, they must have excellent biocompatibility. The key to the design of ideal biomedical materials lies in the effective regulation of the interaction between the life system and the material interface at the molecular and cellular levels, and biomimetic material technology has been considered an important way to develop high-quality biom...

Examples

Embodiment 1

[0024] Embodiment 1, The preparation of the polymer liquid crystal membrane material of the imitation cell membrane structure of the present invention

[0025] (1) Dissolve butyl hydroxypropyl cellulose (BPC), which is in a liquid crystal state at physiological temperature, in acetone to form a homogeneous solution with a mass concentration of 1%, and spray it on a medical stainless steel sheet to form a BPC liquid crystal film;

[0026] (2) Set the area to 20cm 2 Immerse the BPC liquid crystal film in 20mL of 2wt% methacryloxyethyl phosphorylcholine and 0.02mol / L ferric sulfate solution, soak for 2h at room temperature; then irradiate with high-energy electron beams, with a total irradiation dose of 60kGy;

[0027] (3) Take out the irradiated liquid crystal film, wash it with deionized water, and dry it in vacuum at room temperature to obtain a polymer liquid crystal film material with a cell membrane structure: the hydroxyl group of polymethacryloyloxyethylphosphorylcholin...

Embodiment 2

[0028] Embodiment 2, The preparation of the polymer liquid crystal membrane material of the imitation cell membrane structure of the present invention

[0029] (1) Dissolve hydroxypropyl cellulose octyl ester (OPC) which is in a liquid crystal state at physiological temperature in tetrahydrofuran to form a homogeneous solution with a mass concentration of 6%, and cast it on a PET base film to form an OPC liquid crystal film;

[0030] (2) At room temperature, the area is 10cm 2 Immerse the OPC liquid crystal film in 10mL of 5wt% methacryloyloxyethylphosphorylcholine and 0.05mol / L copper nitrate solution for 12h; then irradiate with high-energy electron beams, with a total irradiation dose of 20kGy;

[0031] (3) Take out the irradiated liquid crystal film, wash it with deionized water, and dry it in vacuum at room temperature to obtain a polymer liquid crystal film material with a cell membrane structure: the hydroxyl group of polymethacryloyloxyethylphosphorylcholine grafted ...

Embodiment 3

[0032] Embodiment 3, The preparation of the polymer liquid crystal membrane material of the imitation cell membrane structure of the present invention

[0033] (1) Dissolve hydroxypropyl cellulose propyl ester (PPC), which is in a liquid crystal state at physiological temperature, in acetone to form a homogeneous solution with a mass concentration of 8%, and dip-coat it on a polyurethane tube to form a PPC liquid crystal film;

[0034] (2) Set the area to 10cm 2 The PPC liquid crystal film was immersed in 20mL of 8wt% methacryloxyethyl phosphorylcholine and 0.05mol / L ferric sulfate solution, soaked at 50°C for 1h; then used 60 Co-γ rays are irradiated in a nitrogen atmosphere, and the total irradiation dose is 30kGy;

[0035] (3) Take out the irradiated liquid crystal film, wash it with deionized water, and dry it in vacuum at 40°C to obtain a polymer liquid crystal film material with a cell membrane structure: surface-grafted polymethacryloyloxyethylphosphorylcholine Hydrox...

technical field

[0001] The invention belongs to the field of biomedical materials, and in particular relates to the preparation and application of a polymer liquid crystal membrane material imitating a cell membrane structure. Background technique

[0002] With the development of biomedicine, the application of biomaterials has become more and more extensive and important, and the key performance of biomaterials is their biocompatibility. Since biomedical materials often need to be in contact with the human body surface, blood, and body fluids, and some even require permanent implantation in the body, in order to ensure the safety of their use, they must have excellent biocompatibility. The key to the design of ideal biomedical materials lies in the effective regulation of the interaction between the life system and the material interface at the molecular and cellular levels, and biomimetic material technology has been considered an important way to develop high-quality biom...

Examples

Embodiment 1

[0024] Embodiment 1, The preparation of the polymer liquid crystal membrane material of the imitation cell membrane structure of the present invention

[0025] (1) Dissolve butyl hydroxypropyl cellulose (BPC), which is in a liquid crystal state at physiological temperature, in acetone to form a homogeneous solution with a mass concentration of 1%, and spray it on a medical stainless steel sheet to form a BPC liquid crystal film;

[0026] (2) Set the area to 20cm 2 Immerse the BPC liquid crystal film in 20mL of 2wt% methacryloxyethyl phosphorylcholine and 0.02mol / L ferric sulfate solution, soak for 2h at room temperature; then irradiate with high-energy electron beams, with a total irradiation dose of 60kGy;

[0027] (3) Take out the irradiated liquid crystal film, wash it with deionized water, and dry it in vacuum at room temperature to obtain a polymer liquid crystal film material with a cell membrane structure: the hydroxyl group of polymethacryloyloxyethylphosphorylcholin...

Embodiment 2

[0028] Embodiment 2, The preparation of the polymer liquid crystal membrane material of the imitation cell membrane structure of the present invention

[0029] (1) Dissolve hydroxypropyl cellulose octyl ester (OPC) which is in a liquid crystal state at physiological temperature in tetrahydrofuran to form a homogeneous solution with a mass concentration of 6%, and cast it on a PET base film to form an OPC liquid crystal film;

[0030] (2) At room temperature, the area is 10cm 2 Immerse the OPC liquid crystal film in 10mL of 5wt% methacryloyloxyethylphosphorylcholine and 0.05mol / L copper nitrate solution for 12h; then irradiate with high-energy electron beams, with a total irradiation dose of 20kGy;

[0031] (3) Take out the irradiated liquid crystal film, wash it with deionized water, and dry it in vacuum at room temperature to obtain a polymer liquid crystal film material with a cell membrane structure: the hydroxyl group of polymethacryloyloxyethylphosphorylcholine grafted ...

Embodiment 3

[0032] Embodiment 3, The preparation of the polymer liquid crystal membrane material of the imitation cell membrane structure of the present invention

[0033] (1) Dissolve hydroxypropyl cellulose propyl ester (PPC), which is in a liquid crystal state at physiological temperature, in acetone to form a homogeneous solution with a mass concentration of 8%, and dip-coat it on a polyurethane tube to form a PPC liquid crystal film;

[0034] (2) Set the area to 10cm 2 The PPC liquid crystal film was immersed in 20mL of 8wt% methacryloxyethyl phosphorylcholine and 0.05mol / L ferric sulfate solution, soaked at 50°C for 1h; then used 60 Co-γ rays are irradiated in a nitrogen atmosphere, and the total irradiation dose is 30kGy;

[0035] (3) Take out the irradiated liquid crystal film, wash it with deionized water, and dry it in vacuum at 40°C to obtain a polymer liquid crystal film material with a cell membrane structure: surface-grafted polymethacryloyloxyethylphosphorylcholine Hydrox...

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