A kind of gold nanorod region modified intraocular lens and preparation method and use thereof

Abstract

The invention provides an intraocular lens regionally modified by a gold nanorod, and a preparation method and application thereof. The intraocular lens comprises an intraocular lens body and the gold nanorod coated by a connection layer, wherein the connection layer is connected with the equatorial region of the intraocular lens body. The intraocular lens is prepared by subjecting the equatorial region of the intraocular lens body to hydroxyl modification and then to chemical bonding with the gold nanorod. The intraocular lens regionally modified by the gold nanorod poses no influence on the optical performance of the intraocular lens body, has good biological compatibility, can realize real-time controllable killing of lens epithelial cells and effectively reduce the recurrence rate of cataract, and overcomes the serious clinical problem of after cataract. The intraocular lens enables chemicals to selectively act on the lens epithelial cells without injuring other tissue in eyes and provides a novel thought, approach and method for prevention of after cataract.

Description

technical field

[0001] The invention belongs to the technical field of intraocular lens, relates to an intraocular lens and its preparation method and application, in particular to a gold nanorod domain-modified intraocular lens for preventing and / or treating after-occurring cataract, and its preparation method and application. Background technique

[0002] Cataract lens opacity, commonly known as cataract, with the aging of the global population, the incidence rate and the total number of affected population are increasing. Cataract has become the world's first blinding eye disease. Among the 40-45 million blind people in the world, 46% of them are blinded by cataract. At present, there are 6.7 million cataract patients in my country, and about 1.3 million new cataract-blind people are added every year. Cataracts cause blurred vision or even blindness, causing great inconvenience and pain to cataract patients. Surgical removal of the cataract lens and intraocular intraocul...

Examples

Embodiment 1

[0055] an intraocular lens such as figure 1 shown. The intraocular lens comprises an intraocular lens body and gold nanorods coated with a silicon dioxide layer on the surface, and the silicon dioxide layer is bonded to the equator of the intraocular lens body; the diameter of the gold nanorods is 4nm; length and diameter The ratio is 3; the thickness of the silicon dioxide layer is 30nm; the material of the intraocular lens body is hydrophilic acrylate polymer.

[0056] The preparation method of described intraocular lens comprises the steps:

[0057] (1) Cover the surface outside the equatorial part of the intraocular lens body with 3M adhesive tape, and use plasma surface treatment to modify the equatorial part of the intraocular lens body with hydroxyl groups, wherein the discharge gas source for the plasma surface treatment is argon , the discharge power is 29.6W, and the plasma treatment time is 5min;

[0058] (2) Soak the intraocular lens body with hydroxyl group mod...

Embodiment 2

[0077] An artificial lens comprises an artificial lens body and a gold nanorod covered with a silicon dioxide layer on the surface, and the silicon dioxide layer on the surface of the gold nanorod is bonded to the equator of the artificial lens body. The diameter of the gold nanorod is 2nm; the ratio of length to diameter is 2; the thickness of the silicon dioxide layer is 10nm; the material of the artificial lens is silica gel.

[0078] The preparation method of described intraocular lens comprises the steps:

[0079] (1) Cover the surface outside the equatorial part of the intraocular lens body with 3M adhesive tape, and use plasma surface treatment to modify the equatorial part of the intraocular lens body with hydroxyl groups, wherein the discharge gas source for the plasma surface treatment is argon and nitrogen, the discharge power is 14W, and the treatment time is 600min;

[0080] (2) Soak the intraocular lens body with the hydroxyl group modified at the equator in a c...

Embodiment 3

[0083] An artificial lens comprises an artificial lens body and a gold nanorod covered with a silicon dioxide layer on the surface, and the silicon dioxide layer on the surface of the gold nanorod is bonded to the equator of the artificial lens body. The diameter of the gold nanorod is 20nm; the ratio of length to diameter is 10; the thickness of the silicon dioxide layer is 35nm; the material of the artificial lens is silicone gel.

[0084] The preparation method of described intraocular lens comprises the steps:

[0085] (1) Cover the surface outside the equatorial part of the intraocular lens body with 3M tape, and use plasma surface treatment to modify the equatorial part of the intraocular lens body with hydroxyl groups, wherein the discharge gas source of the plasma surface treatment is oxygen, The discharge power is 200W, and the treatment time is 1min; the thickness of the silicon dioxide layer is 35nm;

[0086] (2) Soak the intraocular lens body with the hydroxyl gro...

technical field

[0001] The invention belongs to the technical field of intraocular lens, relates to an intraocular lens and its preparation method and application, in particular to a gold nanorod domain-modified intraocular lens for preventing and / or treating after-occurring cataract, and its preparation method and application. Background technique

[0002] Cataract lens opacity, commonly known as cataract, with the aging of the global population, the incidence rate and the total number of affected population are increasing. Cataract has become the world's first blinding eye disease. Among the 40-45 million blind people in the world, 46% of them are blinded by cataract. At present, there are 6.7 million cataract patients in my country, and about 1.3 million new cataract-blind people are added every year. Cataracts cause blurred vision or even blindness, causing great inconvenience and pain to cataract patients. Surgical removal of the cataract lens and intraocular intraocul...

Examples

Embodiment 1

[0055] an intraocular lens such as figure 1 shown. The intraocular lens comprises an intraocular lens body and gold nanorods coated with a silicon dioxide layer on the surface, and the silicon dioxide layer is bonded to the equator of the intraocular lens body; the diameter of the gold nanorods is 4nm; length and diameter The ratio is 3; the thickness of the silicon dioxide layer is 30nm; the material of the intraocular lens body is hydrophilic acrylate polymer.

[0056] The preparation method of described intraocular lens comprises the steps:

[0057] (1) Cover the surface outside the equatorial part of the intraocular lens body with 3M adhesive tape, and use plasma surface treatment to modify the equatorial part of the intraocular lens body with hydroxyl groups, wherein the discharge gas source for the plasma surface treatment is argon , the discharge power is 29.6W, and the plasma treatment time is 5min;

[0058] (2) Soak the intraocular lens body with hydroxyl group mod...

Embodiment 2

[0077] An artificial lens comprises an artificial lens body and a gold nanorod covered with a silicon dioxide layer on the surface, and the silicon dioxide layer on the surface of the gold nanorod is bonded to the equator of the artificial lens body. The diameter of the gold nanorod is 2nm; the ratio of length to diameter is 2; the thickness of the silicon dioxide layer is 10nm; the material of the artificial lens is silica gel.

[0078] The preparation method of described intraocular lens comprises the steps:

[0079] (1) Cover the surface outside the equatorial part of the intraocular lens body with 3M adhesive tape, and use plasma surface treatment to modify the equatorial part of the intraocular lens body with hydroxyl groups, wherein the discharge gas source for the plasma surface treatment is argon and nitrogen, the discharge power is 14W, and the treatment time is 600min;

[0080] (2) Soak the intraocular lens body with the hydroxyl group modified at the equator in a c...

Embodiment 3

[0083] An artificial lens comprises an artificial lens body and a gold nanorod covered with a silicon dioxide layer on the surface, and the silicon dioxide layer on the surface of the gold nanorod is bonded to the equator of the artificial lens body. The diameter of the gold nanorod is 20nm; the ratio of length to diameter is 10; the thickness of the silicon dioxide layer is 35nm; the material of the artificial lens is silicone gel.

[0084] The preparation method of described intraocular lens comprises the steps:

[0085] (1) Cover the surface outside the equatorial part of the intraocular lens body with 3M tape, and use plasma surface treatment to modify the equatorial part of the intraocular lens body with hydroxyl groups, wherein the discharge gas source of the plasma surface treatment is oxygen, The discharge power is 200W, and the treatment time is 1min; the thickness of the silicon dioxide layer is 35nm;

[0086] (2) Soak the intraocular lens body with the hydroxyl gro...

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