A kind of bactericidal composition containing cloconazole and thiram and its application

Abstract

The invention discloses a bactericidal composition containing ipconazole and thiram and an application thereof. The bactericidal composition takes ipconazole and thiram as main active ingredients with the weight ratio of 1:40-24:1. The bactericidal composition can be applied for prevention and treatment of wheat scab, wheat rust disease, wheat powdery mildew, wheat leaf blight, downy mildew of cucurbits, and crop gray mold, has relatively good synergistic effects, overcomes and delays drug resistance of pathogenic bacteria, has the advantages of good fast-acting property, low residues, long period of preserving effect and environmental friendliness, reduces the application cost, and has important practical significance on increasing social, economic and ecological benefits.

Description

Technical field

[0001] The invention relates to a bactericidal composition containing inoconazole and thiram and its application, and belongs to the pesticide composition with synergistic and dose-reducing effects in the technical field of pesticides, and its active ingredients are inoconazole and thiram. Background technique

[0002] Conazole, English common name: Ipconazole, molecular formula: C 18 H 24 ClN 3 O, chemical name: 2-((4-chlorobenzyl)methyl-5-(1-isopropyl)-1-(1H-1,2,4-triazole-1-methyl)cyclopentanol , The molecular structure is as follows:

[0003]

[0004] Conazole is a triazole ergosterol biosynthesis inhibitor. It has systemic, protective and therapeutic activities. It can effectively prevent diseases caused by ascomycetes, basidiomycetes and deuteromycetes. It is conducted from roots to stems and leaves through seed treatment. It has good control effect on head blight, leaf spot and fusarium wilt.

[0005] Fumei double, English common name: Thiram, molecular formu...

Examples

experiment example

[0024] Experimental example: indoor activity measurement

[0025] To be sensitive to carbendazim (MBC S ) And drug resistance (MBC R ) Was used as the test target, and the virulence and the synergistic coefficient of the target were tested indoors with different ratios of inoconazole and thiram. The method uses inoconazole and thiram original medicinal methanol to dissolve into 1000 μg / mL mother liquor, and store at 4°C for later use. Inoconazole and thiram are formulated into a mixture of 1:40, 1:20, 1:10, 1:5, 1:1, 3:1, 6:1, 12:1, 24:1 according to the effective content. The series of test solutions were mixed with the culture medium (PDA) to determine the sensitivity to wheat head blight and carbendazim (MBC S ) And resistance (MBC R ) Inhibitory activity of strain mycelial growth, calculate EC 50 Value and synergy factor.

[0026] Average inhibition rate of mycelial growth=[(average control colony diameter-average treatment colony diameter) / (average control colony diameter-ino...

Embodiment 1

[0031] Example 1: 50% inoconazole·thiram wettable powder

[0032] Seeconazole 10%, Thiram 40%, NNO-1 4%, Sodium Lignosulfonate 5%, Attapulgite 30%, White Carbon Black 8%, and the rest is kaolin supplemented to 100%. The above components are thoroughly mixed, crushed by a sand mill and sieved through a 300-mesh sieve, to obtain a 50% inoconazole·thiram wettable powder.

Embodiment 2

[0033] Example 2: 28% inoconazole·thiram wettable powder

[0034] Seeconazole 20%, thiram 8%, NNO-1 4%, sodium lignosulfonate 5%, attapulgite 30%, white carbon black 8%, and the rest is kaolin supplemented to 100%. The above components are thoroughly mixed, crushed by a sand mill and sieved through a 300-mesh sieve, to obtain 28% conazole·thiram wettable powder.

Technical field

[0001] The invention relates to a bactericidal composition containing inoconazole and thiram and its application, and belongs to the pesticide composition with synergistic and dose-reducing effects in the technical field of pesticides, and its active ingredients are inoconazole and thiram. Background technique

[0002] Conazole, English common name: Ipconazole, molecular formula: C 18 H 24 ClN 3 O, chemical name: 2-((4-chlorobenzyl)methyl-5-(1-isopropyl)-1-(1H-1,2,4-triazole-1-methyl)cyclopentanol , The molecular structure is as follows:

[0003]

[0004] Conazole is a triazole ergosterol biosynthesis inhibitor. It has systemic, protective and therapeutic activities. It can effectively prevent diseases caused by ascomycetes, basidiomycetes and deuteromycetes. It is conducted from roots to stems and leaves through seed treatment. It has good control effect on head blight, leaf spot and fusarium wilt.

[0005] Fumei double, English common name: Thiram, molecular formu...

Examples

experiment example

[0024] Experimental example: indoor activity measurement

[0025] To be sensitive to carbendazim (MBC S ) And drug resistance (MBC R ) Was used as the test target, and the virulence and the synergistic coefficient of the target were tested indoors with different ratios of inoconazole and thiram. The method uses inoconazole and thiram original medicinal methanol to dissolve into 1000 μg / mL mother liquor, and store at 4°C for later use. Inoconazole and thiram are formulated into a mixture of 1:40, 1:20, 1:10, 1:5, 1:1, 3:1, 6:1, 12:1, 24:1 according to the effective content. The series of test solutions were mixed with the culture medium (PDA) to determine the sensitivity to wheat head blight and carbendazim (MBC S ) And resistance (MBC R ) Inhibitory activity of strain mycelial growth, calculate EC 50 Value and synergy factor.

[0026] Average inhibition rate of mycelial growth=[(average control colony diameter-average treatment colony diameter) / (average control colony diameter-ino...

Embodiment 1

[0031] Example 1: 50% inoconazole·thiram wettable powder

[0032] Seeconazole 10%, Thiram 40%, NNO-1 4%, Sodium Lignosulfonate 5%, Attapulgite 30%, White Carbon Black 8%, and the rest is kaolin supplemented to 100%. The above components are thoroughly mixed, crushed by a sand mill and sieved through a 300-mesh sieve, to obtain a 50% inoconazole·thiram wettable powder.

Embodiment 2

[0033] Example 2: 28% inoconazole·thiram wettable powder

[0034] Seeconazole 20%, thiram 8%, NNO-1 4%, sodium lignosulfonate 5%, attapulgite 30%, white carbon black 8%, and the rest is kaolin supplemented to 100%. The above components are thoroughly mixed, crushed by a sand mill and sieved through a 300-mesh sieve, to obtain 28% conazole·thiram wettable powder.

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