Eccentric structure polymer microsphere and preparation method thereof

Abstract

The invention discloses an eccentric structure polymer microsphere and a preparation method thereof and mainly relates to the field of high polymer material processing. The method comprises the following steps that by organically combining a micro-fluidic control technology and an electrostatic spraying technology and by matching with proper internal-phase solution and external-phase solution, themonodisperse eccentric structure polymer microsphere with controllable size and morphology; and by regulating relevant parameters, relative regulation and control of shell thickness, eccentric area,eccentric degree and size of the microsphere are realized. Therefore, due to a unique structure and a controllable preparation method, the eccentric structure polymer microsphere has good biocompatibility, controlled drug release ability and ability of loading hydrophilic and hydrophobic materials and thus has important popularization and application values.

Description

technical field

[0001] The invention relates to the field of polymer material processing, in particular to a polymer microsphere with an eccentric structure and a preparation method thereof. Background technique

[0002] Electrospray technology refers to the process of polymer melt or solution forming microspheres under the action of high-voltage electrostatic field. Due to the high monodispersity, high drug loading rate and high repeatability of the prepared microspheres, and the low cost of electrospray technology, and easy operation and improvement, it is widely used in the preparation of nano-drug carriers, double-loaded growth Factor microcapsules, multi-chamber carriers, red blood cell-sized microsphere carriers and other biomedical fields and other research fields.

[0003] However, the existing methods for preparing microspheres have a relatively complicated preparation process, and relatively poor operability and controllability, which have affected the structure a...

Examples

Embodiment 1

[0033] This embodiment provides a method for preparing polymer microspheres with an eccentric structure, and the preparation process is as follows:

[0034] First, 2 mL of glycerin was dissolved in 0.5 mL of deionized water, and magnetically stirred for 12 h to make it uniformly mixed to obtain an internal phase solution. Dissolve 2 g of polylactic acid-glycolic acid copolymer in 10 mL of dimethyl carbonate, and stir for 12 h to make it uniformly mixed to obtain an external phase solution.

[0035] Then, the internal phase and the external phase are respectively pushed into the corresponding injection ports of the microfluidic device through the Teflon tube at the pushing speed of 0.2mL / h and 0.6mL / h, and the oil-packed phase is formed under the action of shear force. Water type EFI. Emulsion droplets with uniform size and equal spacing can be observed at the outlet tube of the microfluidic device. Among them, the size and spacing of milk droplets can be regulated by adjusti...

Embodiment 2

[0039] This example provides a method for preparing polymer microspheres with an eccentric structure, which is roughly the same as the method for preparing polymer microspheres with an eccentric structure provided in Example 1, except that 1 g of polylactic acid-glycolic acid is used in this example The copolymer was dissolved in 10 mL of dimethyl carbonate, and magnetically stirred for 12 hours for uniform mixing to obtain an external phase solution.

[0040] Further, different from Example 1, the pushing speeds of the internal phase solution and the external phase solution of this embodiment are 0.2mL / h and 0.8mL / h respectively. It should be noted that the rest of the parameters and the preparation process of this embodiment are the same as those of Embodiment 1.

[0041] This embodiment also provides a polymer microsphere with an eccentric structure, which is prepared by the method for preparing the polymer microsphere with an eccentric structure provided in this embodiment...

Embodiment 3

[0043] This example provides a method for preparing polymer microspheres with an eccentric structure, which is roughly the same as the method for preparing polymer microspheres with an eccentric structure provided in Example 1, except that this example uses 2 g of polylactic acid-polyethylene The diol copolymer was dissolved in 10 mL of dimethyl carbonate, and magnetically stirred for 12 hours for uniform mixing to obtain an external phase solution. It should be noted that the rest of the parameters and the preparation process of this embodiment are the same as those of Embodiment 1.

[0044] This embodiment also provides a polymer microsphere with an eccentric structure, which is prepared by the method for preparing the polymer microsphere with an eccentric structure provided in this embodiment.

technical field

[0001] The invention relates to the field of polymer material processing, in particular to a polymer microsphere with an eccentric structure and a preparation method thereof. Background technique

[0002] Electrospray technology refers to the process of polymer melt or solution forming microspheres under the action of high-voltage electrostatic field. Due to the high monodispersity, high drug loading rate and high repeatability of the prepared microspheres, and the low cost of electrospray technology, and easy operation and improvement, it is widely used in the preparation of nano-drug carriers, double-loaded growth Factor microcapsules, multi-chamber carriers, red blood cell-sized microsphere carriers and other biomedical fields and other research fields.

[0003] However, the existing methods for preparing microspheres have a relatively complicated preparation process, and relatively poor operability and controllability, which have affected the structure a...

Examples

Embodiment 1

[0033] This embodiment provides a method for preparing polymer microspheres with an eccentric structure, and the preparation process is as follows:

[0034] First, 2 mL of glycerin was dissolved in 0.5 mL of deionized water, and magnetically stirred for 12 h to make it uniformly mixed to obtain an internal phase solution. Dissolve 2 g of polylactic acid-glycolic acid copolymer in 10 mL of dimethyl carbonate, and stir for 12 h to make it uniformly mixed to obtain an external phase solution.

[0035] Then, the internal phase and the external phase are respectively pushed into the corresponding injection ports of the microfluidic device through the Teflon tube at the pushing speed of 0.2mL / h and 0.6mL / h, and the oil-packed phase is formed under the action of shear force. Water type EFI. Emulsion droplets with uniform size and equal spacing can be observed at the outlet tube of the microfluidic device. Among them, the size and spacing of milk droplets can be regulated by adjusti...

Embodiment 2

[0039] This example provides a method for preparing polymer microspheres with an eccentric structure, which is roughly the same as the method for preparing polymer microspheres with an eccentric structure provided in Example 1, except that 1 g of polylactic acid-glycolic acid is used in this example The copolymer was dissolved in 10 mL of dimethyl carbonate, and magnetically stirred for 12 hours for uniform mixing to obtain an external phase solution.

[0040] Further, different from Example 1, the pushing speeds of the internal phase solution and the external phase solution of this embodiment are 0.2mL / h and 0.8mL / h respectively. It should be noted that the rest of the parameters and the preparation process of this embodiment are the same as those of Embodiment 1.

[0041] This embodiment also provides a polymer microsphere with an eccentric structure, which is prepared by the method for preparing the polymer microsphere with an eccentric structure provided in this embodiment...

Embodiment 3

[0043] This example provides a method for preparing polymer microspheres with an eccentric structure, which is roughly the same as the method for preparing polymer microspheres with an eccentric structure provided in Example 1, except that this example uses 2 g of polylactic acid-polyethylene The diol copolymer was dissolved in 10 mL of dimethyl carbonate, and magnetically stirred for 12 hours for uniform mixing to obtain an external phase solution. It should be noted that the rest of the parameters and the preparation process of this embodiment are the same as those of Embodiment 1.

[0044] This embodiment also provides a polymer microsphere with an eccentric structure, which is prepared by the method for preparing the polymer microsphere with an eccentric structure provided in this embodiment.

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