The invention discloses a propamidine water dispersible granule (WDG) and a preparation method thereof. Prepared propamidine water dispersible granules comprise the following raw materials in percentage by weight: 85-90 percent of propamidine, 2.5-5 percent of dispersant, 2.5-5 percent of humectant and 2.5-5 percent of disintegrating agent, and the total percentage of the raw materials is 100. The preparation method comprises the steps as follows: the raw materials in a formula, including the propamidine, the humectant, the dispersant and the disintegrating agent, are uniformly mixed, crushed by an airflow crushing machine, and made into ultra-fine wettable powder, then the ultra-fine wettable powder is added with a certain amount of water, and made into granules via an extrusion type granulator, the granules are dried by an airflow drier, and screened and separated, as a result, the water dispersible granules are obtained. According to the invention, the cost of package and transport can be effectively reduced, the storage stability and the shelf life of the WDG are increased, the safety and the performance of environmental protection in links about the production and the utilization of the propamidine WDG are also improved, and the plant botrytis cinerea pathogenic bacterium can be very efficiently prevented and treated.