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Propamidine is an antiseptic and disinfectant. Propamidine isethionate, the salt of propamidine with isethionic acid, is used in the treatment of Acanthamoeba infection. Propamidine is a member of the aromatic diamidine group of compounds which possess bacteriostatic properties against a wide range of organisms. These diamidines exert antibacterial action against pyrogenic cocci, antibiotic resistant staphylococci and some Gram-negative bacilli, the activity of the diamidines being retained in the presence of organic matter such as tissue fluids, pus and serum.
A process for the preparation of propamidine
PendingCN122145330AOrganic compound preparationOrganic-compounds/hydrides/coordination-complexes catalystsPropizochlorPropanidid
The application discloses a method for preparing propafenone, and belongs to the technical field of drug synthesis. The method comprises the following steps: (1) taking 4-bromoguaiacol as raw material to perform etherification reaction with N,N-diethylchloroacetamide to obtain an intermediate A; (2) performing cross coupling reaction on the intermediate A and dipropyl malonate under the catalysis of a copper / oxamide ligand combination system to obtain an intermediate B; and (3) performing decarboxylation on the intermediate B by heating to obtain the propafenone. The raw material is cheap and easy to obtain, the route is short, the operation is simple, and the method has good industrial application value.
Owner:EAST CHINA UNIV OF SCI & TECH