2results about How to "Avoid using directly" patented technology

The invention relates to the field of medicinal chemistry, and particularly discloses a novel TLR8 agonist intermediate as well as a preparation method and application thereof, which are suitable for process development of 4, 6-diaminopyridino [3, 2-d] pyrimidine TLR8 agonists. According to the preparation method, tert-butyl is adopted to replace 2, 4-dimethoxybenzyl to serve as an amino protecting group, so that the crystallization property of the intermediate is remarkably improved, column chromatography is avoided, the cost is reduced, and the process stability is improved. The preparation method of the TLR8 agonist intermediate comprises the steps of reduction, acylating chlorination, coupling, amination and the like, has the advantages of being easy and convenient to operate, high in yield, environmentally friendly and the like, and is particularly suitable for industrial production.

This invention discloses a pesticide reduction and enhancement adjuvant and its preparation method, belonging to the field of pesticide technology. The adjuvant is composed of 7-9 parts potassium oleate, 1-2 parts dipotassium hydrogen phosphate, and 1-2 parts 2-ethylidene-5-phenylvaleric acid. The preparation method involves stirring and mixing the components at room temperature to form a homogeneous solution. When used in combination with chemical pesticides such as triadimefon, carbendazim, and pyraclostrobin, this adjuvant can significantly enhance pesticide efficacy. Even with a 50%-80% reduction in chemical pesticide usage, the control efficacy remains above 90%, effectively reducing pesticide residues and environmental risks. This invention has the advantages of simple composition, low cost, and environmentally friendly process, and is suitable for reducing pesticide use and increasing efficiency in agricultural production.