31results about How to "Dysregulation" patented technology

The invention discloses Bacillus licheniformis H2 which is resistant to acid, heat and cholate and has good resistance to Clostridium perfringens and application of Bacillus licheniformis H2 in prevention and control of necrotic enteritis in chicken. The strain is obtained by separation, screening and identification, and has the preservation number of CCTCC NO: M2011133; and Bacillus licheniformis H2 can be prepared into a microorganism preparation, and can effectively prevent and control necrotic enteritis in chicken caused by Clostridium perfringens, promote growth of normal physiological anaerobic bacteria in intestinal tract of chicken, improve intestinal tract microorganism diversity and immune organ index of chicken and improve growth performance of chicken when used as a veterinary medicine and chicken feed additive. Bacillus licheniformis H2 is suitable for feed factories, veterinary drug factories and scaled chicken farms.

The invention discloses a DHA (docosahexaenoic acid) cheese sandwich biscuit and a preparation method of the DHA cheese sandwich biscuit, and belongs to the technical field of nutritious food processing. The DHA cheese sandwich biscuit is characterized by comprising two parts including a biscuit and a DHA cheese sandwich material, wherein the biscuit is selected from one kind of crispy biscuits, hard biscuits, soda biscuits, cookie biscuits, wafer biscuits and thin and brittle biscuits made in the prior art, the DHA cheese sandwich material consists of raw materials including cheese powder, mycose, erythritol, cream, algae oil, DHA and lutein ester, and the mass ratio of the sandwich material to the biscuit is 1:(3 to 3.5). The DHA cheese sandwich biscuit and the preparation method thereof have the advantages that the effects of nutrition complementation and synergetic gain are fully realized, and the market blank is filled; the mouth feeling is better, the eating is convenient, the safety is good, the acceptability is high, and no toxic or side effect exists; after eating, the visual fatigue can be obviously relieved, the digestion is promoted, the intestinal flora imbalance is regulated, the memory is improved, auxiliary protection effects can be realized on hypertension, hyperlipidemia and high blood glucose cardiovascular diseases, the immunity is improved, and the body health is maintained; the production process is simple, the control is easy, and great market development potential is realized.

The invention provides a lactobacillus plantarum AR113 strain with a protection function on stroke. The lactobacillus plantarum AR113 is preserved in the China General Microbiological Culture Collection Center on March 22, 2017, and the preservation number is CGMCCC No.13909. By adopting the lactobacillus plantarum AR113 strain provided by the invention is capable of improving antioxidant enzyme activities of brain tissue, reducing levels of oxidation products, activating Nrf-ARE signal channels, regulating relative expression amounts of antioxidation factors Nrf2, NQO01 and HO-1, meanwhile, reducing miRNA (micro ribonucleic acid) expression of apoptosis-promoting factors Cyt-C, Caspase-3 and Bax, increasing relative expression of an anti-apoptosis factor Bcl-2, and furthermore, relievingbran cell damage caused by cerebral ischemia reperfusion.

The invention discloses cassava residue biological feed and a making method of the cassava residue biological feed. The making method comprises the steps that cassava residues are smashed firstly, then the smashed cassava residues are soaked in a water pool for 24 hours, sediments are taken out, fermentation is conducted on the sediments after yeast is added to the sediments, the moisture content of raw materials is controlled to be 40%, after the raw materials are mixed evenly, the raw materials are stacked in a strip shape, the PH value is controlled to be 7, the fermentation temperature is 35+ / -1 DEG C, anaerobic fermentation is conducted for 48-96 hours, fermented products are dried at the temperature of 85-95 and cooled to cooled to the temperature within five DEC G higher than the indoor temperature, 50-55% of the cassava residues, 10-25% of oil bran or wheat bran, 5-10% of corns and 1-10% of bean pulp are mixed and fermented according to a weight ratio and smashed, compound microorganism strains and flavor improving agents are added to the mixture and evenly mixed with the mixture, and then the final mixture is packaged in a quantified mode. By means of the cassava residue biological feed and the making method of the cassava residue biological feed, production cost and environment cost can be lowered, the environment is protected, and the development of the ecological breeding industry is promoted.

An application of butanoic acid bacteria in preparation of candy. The invention relates to novel usage of butanoic acid bacteria in field of candy preparation, the butanoic acid bacteria candy has many actions when it is considered as a candy food and is eat for long time, such as maintaining the stability of normal bacteria in intestinal canal, maintaining the body in a state of good health, adjusting the imbalance of bacteria in intestinal canal, improving the action of micro-ecologic environment, playing a role of adjusting the intestine and defending infection, and the butanoic acid bacteria can adjust the normal creeping motion of intestine to achieving the action of softening stool, releasing or eliminating constipation, eliminating abdominal distention and adjusting, treating, preventing constipation, the butanoic acid bacteria candy can improve the immune function, inhibiting and rreleasing anaphylaxis, improving the role of the liver.

The invention discloses an application of clostridium butyrate in a preparation for prevention and treatment or adjuvant therapy of hyperglycemia and belongs to the technical field of prevention and treatment of diabetes. According to the application, during the prevention and treatment or adjuvant therapy of the hyperglycemia, butyric acid is produced in an intestinal tract, meanwhile, florae of the intestinal tract are changed, signals are sent to an ileum, a liver, a pancreatic gland and a brain by a portal vein blood sugar sensor, the ileum is promoted to secrete (GLP-1) glucagon-like peptide-1, the gluconeogenesis of the liver is lowered, pancreatic beta cells are protected, the secretion of insulin of the pancreatic gland is promoted, and thus, the action of reducing blood sugar is exerted. The clostridium butyrate is a medicine which has been proven by clinical drug trials and can be directly taken orally.

The invention provides a cordycepin-containing composition, and belongs to the field of traditional Chinese medicine preparations. The cordycepin-containing composition is prepared from the followingraw materials in parts by weight: 0.1 to 3 parts of cordycepin and 1 to 12 parts of nuciferine. The cordycepin-containing composition provided by the invention is simple in compatibility, the source of raw materials is wide, accumulation of white fat and the contents of serum TC (Total Cholesterol), TG (Triglyceride) and LDL (Low-Density Lipoprotein) can be remarkably reduced, the content of HDL (High-Density Lipoprotein) can be remarkably increased, the protein level of a adenosine A1 receptor of a GH3 cell can be induced to be increased, and lactation release of the GH3 cell can be remarkably inhibited; visually, the cordycepin-containing composition provided by the invention is capable of preventing obesity, losing weight, preventing / treating hyperlipidemia, conditioning lipoprotein abnormality, conditioning lipid metabolism and reducing an occurrence rate of a coronary heart disease at the same time.

The invention discloses acid-proof cholate-resisting dog source bacillus licheniformis Y10 with acid resistance, cholate resistance and good antibacterial effect and application of the dog source bacillus licheniformis Y10 in prevention and treatment of dog enteritis and dysentery. The dog source bacillus licheniformis Y10 is obtained through separation, screening and identification, and the preservation number is CCTCC NO: M2011134; the bacillus licheniformis Y10 can be prepared into a micro-ecological agent to be used as a veterinary medicine and a dog food additive for regulating alteration of intestinal flora, increasing microbial diversity and immune organ index of dog intestinal tract, improving dog growth performance, effectively preventing dog dysentery, and providing a new concept for prevention of bacterial diseases of dog intestinal tract and a feasible alternate strain for development of the dog source micro-ecological agent. The dog source bacillus licheniformis Y10 is suitable for feed mills and large-scale dog-breeding kennels.

The invention discloses probiotics fermented milk and a preparation technology thereof. The preparation technology comprises the following steps of pretreating, centrifuging and separating, fermenting, material mixing, filling and storing. The preparation technology has the advantages that multiple bacterial strains are inoculated at one time in the fermenting process, and the temperature in different fermenting phases is controlled to control the growth rates of different bacterial strains, so that the different bacterial stains can reach the pilot function; the survival rate of probiotics in the fermenting process is improved; the production technology is simplified, and the probiotics fermented milk with high nutritional value, more probiotics and long quality warranty period is obtained.

The invention discloses laying hen feed capable of producing high-folate nutritional eggs and a preparation method of the laying hen feed. The laying hen feed contains base yeasts, folate yeast autolysate and glycyl glutamine, wherein based on the weight of the base yeasts, the content of the folate yeast autolysate is 5-7.5wt%, and the content of the glycyl glutamine is 0.01-0.5wt%. The base yeasts are products obtained by inoculating bacillus cereus and bacillus megaterium to the base material of the laying hen feed, and performing ventilation fermentation; and the folate yeast autolysate isprepared by the following method steps: respectively adding folic acid into beer yeasts in the logarithmic growth phase and at the stationary growth stage, fermenting, collecting the bacterium liquid, and preparing thallus; mixing the inactivated thallus and neutral protease, and performing autolysis; and cooling and collecting the autolysis liquid, centrifuging to obtain a precipitate, and performing freeze-drying on the precipitate, thereby obtaining the folate yeast autolysate.

Belonging to the technical field of feed additive formulation design, the invention specifically relates to a novel green broiler chicken feed additive, which has a formula composed of a probiotic composition, xylanase, polysaccharide and a carrier. Application of the feed additive in broiler chicken breeding can obviously enhance the daily gain of broiler chickens, raise the utilization efficiency of broiler chickens on daily ration, reduce the feed meat ratio, improve the growth performance of broiler chickens, and is free of drug resistance, drug residual and other problems, so that the chicken meat quality is good.

The invention provides a slimming and fat reducing composition and application thereof, and relates to the field of biochemical technology. The slimming and fat reducing composition, comprises, by weight, 6-15 parts of berberine hydrochloride and 1-5 parts of aplidium constellatum fat-soluble extract. The aplidium constellatum fat-soluble extract is obtained by homogenizing aplidium constellatum,performing filtering to obtain filtrate, extracting the filtrate by n-butanol and concentrating the extract. The composition has the remarkable effects of reducing body weight and regulating blood lipids, and can obviously prevent and treat hyperlipidemia, prevent obesity, reduce the body weight, regulate lipoprotein abnormality and lipid metabolism, and reduce the incidence of coronary heart disease.

The invention discloses a compound oral liquid for treating children diarrhea and a preparation method thereof. The compound oral liquid for treating the children diarrhea comprises the following components of Nutrilite Double powder, dideoxyinosine, gastrodia elata polypeptide, disaccharidase, ribavirin, racecadotril, bismuth pectin, hydrotalcite, dry yeast, probiotics, potassium chloride, sodium chloride, sodium lactate, calcium gluconate, corrigent, emulsifying agent, buffer liquid, and antioxidant. The compound oral liquid for treating the children diarrhea has the advantages that the environment of children gastrointestinal tracts is improved, the effective microbial community is increased, the digestion and adsorbing of gastrointestinal tract are promoted, the water-electrolyte metabolic disorder is prevented, and the body immunity is improved; the cost is low, the toxic or side effect is little, the compound oral liquid can be used for a long time, and the children diarrhea can be prevented and thoroughly cured after long-time administration.

The present invention belongs to the field of food and particularly relates to synbiotics cereal and vegetable meal replacement powder and a preparation method thereof and an application thereof. Thesynbiotics cereal and vegetable meal replacement powder comprises the following components in 100 g: 60-80 g of highland barley powder, 10-20 g of pumpkin powder, 5-10 g of soybean powder, 5-10 g of konjac flour, 0.5-5.0 g of prebiotics and 10[6]-10[12] cfu of probiotics. The components in the provided synbiotics cereal and vegetable meal replacement powder have multiple effects, are mutually beneficial and mutually reinforced and have synergistic effects on relaxing bowels, regulating imbalance of intestinal flora and controlling blood sugar. The synbiotics cereal and vegetable meal replacement powder can replace breakfast, lunch or dinner, can meet basic needs of energy and nutrients for healthy people or special populations, has a light brown coffee color after being brewed, has a wheatfragrance and is thick and soft in mouthfeel.

A process for preparing the bifidobacterial honey milk for promoting the reproduction of bifidobacterium in human body and improving the gastrointestinal function features that the quality of honey is controlled to have low water content and high-contents of amylase, pectose, glucose and sucrose, the ratio of polyisomaltose to honey is (25-35%): (65-75%), the mixture is filtered multiple times after stirred, it is concentrated at 50 + / - 2 deg.C under -0.2 KPa for 60 min, and its packing material must be sterilized.

The invention provides a special disease-prevention and root growth-promotion powdery agricultural microbial agent for strawberries, and a production technology thereof. The agricultural microbial agent comprises the following components: a carrier which is vermiculite powder; microbial thalluses which are Bacillus licheniformis, Bacillus mucilaginosus, Bacillus cereus and Streptomyces microflavus; a protection agent which comprises glycerol, skimmed milk powder, chitosan, ascorbic acid, citric acid, composite amino acid and dextrin; and an adsorbent which is weathered coal dust, wherein the microbial thalluses are bacterial sludge obtained after centrifugation and precipitation of a fermentation solution. The production technology comprises the following steps: strain activation, shakingculture, fermentation culture, bacterial sludge production, ingredient addition and aseptic packaging. The above formula is specially designed for the strawberries against the easy powdery mildew invasion problem of the strawberries according to the growth characteristics of shallow root system and large blades of the strawberries; the agricultural microbial agent has the advantages of good livingbacterium symbiosis, good stability, and realization of green blades, powdery mildew resistance and obviously enhanced stress resistance of cultivated plants; and the production technology has the advantages of simplicity, low cost, and convenience in promotion and use.

The invention discloses a preparation method of novel fermented golden flaxseed meal and particularly relates to the technical field of feeds. The method includes: 1) preparing a fermenting agent including 15% of lactobacillus acidophilus, 25% of bacillus natto, 15% of lactobacillus plantarum, 20% of enterococcus faecalis, 10% of EM bacteria, and 15% of saccharomycetes; 2) adding water to the fermenting agent and golden flaxseed meal for mixing fermentation under a sealed condition for 70-72 h, wherein the fermenting agent accounts for 0.5 mass% of the golden flaxseed meal. The preparation method is simple, is good in condition controllability, and is short in fermenting time, high in efficiency and low in cost. After fermentation, contents of small-molecular peptides, active probiotics and organic acids in the golden flaxseed meal are high. The fermented golden flaxseed meal is blended with complete pig feed for feeding pigs, thus increasing the content of alpha-linolenic acid and eicosapentaenoic acid (EPA). The product also can effectively increase intake of pigs and increase daily gain and can increase feed conversion ratio and improve the taste and quality of the pork.

The invention discloses a drug capsule for preventing and treatingchronic diarrhea. The drug capsule is prepared from main drug components and a capsuleadjuvant material, and is characterized in that the main drug components compriseextracts of rhizoma atractylodismacrocephalae, rhizoma atractylodis, rhizoma zingiberis, poriacocos, radix glycyrrhizaepreparata, radix saposhnikoviae, pericarpiumcitrireticulatae, radix paeoniae alba, myristicafragrans, fructus evodiae, fructus psoralea, radix angelicae, raw coix seeds, caulis perllae, wrinkled gianthyssopherb, semen euryales,stir-baked rhizoma dioscoreae and fructus schizandrae. The drug capsule can obviously reduce the generation and development of chronic diarrhea, has the functions of improving enteric internal environment, promoting intestinal mucosarepair and regeneration, resisting and defending invasion of harmful microorganisms and absorption of water by intestinal tract, and improving the digestive system, and has the effects of invigorating the spleen, tonifying the kidney, strengthening and consolidating body resistance and treatingboth the symptoms and root causes of diseases.

The invention provides a weight-loss and lipid-lowering composition and an application thereof, and relates to the technical field of biochemistry. The weight-loss and lipid-lowering composition of the invention comprises, in parts by weight, 6-15 parts of berberine hydrochloride and 1-5 parts by weight of berberine hydrochloride. A lipid-soluble extract of Ascidian constellation is obtained; the lipid-soluble extract of Ascidian constellation is obtained by homogenizing the Ascidian constellation, filtering to obtain a filtrate, extracting the filtrate with n-butanol and concentrating. The composition provided by the invention has the functions of significantly reducing body weight and regulating blood lipids, and can obviously prevent and treat hyperlipidemia, prevent obesity, reduce body weight, regulate abnormal lipoproteins, regulate lipid metabolism and reduce the incidence of coronary heart disease.

The invention discloses an application of clostridium butyrate in a preparation for prevention and treatment or adjuvant therapy of hyperglycemia and belongs to the technical field of prevention and treatment of diabetes. According to the application, during the prevention and treatment or adjuvant therapy of the hyperglycemia, butyric acid is produced in an intestinal tract, meanwhile, florae of the intestinal tract are changed, signals are sent to an ileum, a liver, a pancreatic gland and a brain by a portal vein blood sugar sensor, the ileum is promoted to secrete (GLP-1) glucagon-like peptide-1, the gluconeogenesis of the liver is lowered, pancreatic beta cells are protected, the secretion of insulin of the pancreatic gland is promoted, and thus, the action of reducing blood sugar is exerted. The clostridium butyrate is a medicine which has been proven by clinical drug trials and can be directly taken orally.

The invention relates to an externally used medicine waistcoat for treating the gasp syndrome and a medicine preparation method. The waistcoat comprises a front part and a rear part, and the middle of the front part and the middle of the rear part are respectively provided with a medicine bag. Each medicine bag comprises a main medicine core filled with medicine of about 100 g, wherein two auxiliary medicine cores filled with the medicine are arranged on the two sides of the main medicine core respectively, and the main medicine core comprises semen lepidii, semen brassicae, perillaseeds, semen raphani, lumbricus, almonds, asarum, euphorbia kansui, rhizoma zingiberis, trichosanthes kirilowii maxim, roots of red-rooted salvia, platycodon grandiflorum and allium macrostemon and achyranthes roots, and auxiliary materials comprise natural resin, far infrared ceramic powder and azone. The waistcoat adjusts a patient with the gasp syndrome and all internal organs comprehensively, and enables all respiratory organs of the human body to tend to be normal through tonifying qi, purging the lung of pathogenic fire and relieving asthma, and the waistcoat particularly improves lung, spleen and kidney functions more obviously.

The invention discloses drug capsules for preventing and treating chronic atrophic gastritis and belongs to the technical field of drug preparations. The drug capsules are made with a main drug component and a capsule auxiliary material; the main drug component comprises tangshen root, roasted seed of common jujube, roasted rhizome of largehead atractylodes, Poria, prepared licorice root, rhizome of common yam, turmeric rhizome, prepared rhizome of ternate pinellia, and baked ginger; the capsule auxiliary material includes a binder, a filling agent, a cracking agent, an adsorbent, and a lubricant. The drug capsules are capable of significantly decreasing the progress and development of chronic atrophic gastritis, decreasing the complications such as gastric cancer, and maximally increasing the living quality of a patient.

The invention discloses microbial feed and a preparation method thereof. The microbial feed consists of base materials, microorganisms, sugar, table salt and water. The preparation method comprises the following steps: putting the sugar into the water to be stirred for sufficient dissolution, and inoculating the solution with the microorganisms after sterilization for fermentation, thereby obtaining fermentation broth; evenly mixing the base materials, and sterilizing the mixed base materials to obtain sterilized base materials for further use; evenly stirring the fermentation broth and the sterilized base materials for secondary fermentation, thereby obtaining fermented base materials; and subjecting the fermented base materials to coating treatment with the conventional coating process,thereby obtaining the microbial feed. The microbial feed of the invention is high in fermentation efficiency and bioavailability and capable of providing nutrients required for poultry, inhibiting thegrowth of Escherichia coli and other micro-organisms in intestinal tract, promoting intestinal absorption and ensuring the health status of the poultry to a certain extent; and the preparation methodis simple and mild in condition, and the prepared microbial feed can be stored for a long time under certain conditions.

The invention relates to a formula of a bathing product and a preparation method of the bathing product, in particular relates to bubble mud for bathing and the preparation method of the bubble mud, and belongs to the technical field of daily articles. Sandy soil and alum in the formula are traditional Chinese medicines with cold property, play the roles of reducing internal heat, relieving pain, relieving itching, diminishing inflammation, detumescence and degreasing when people usually take bathes with the bubble mud, and have curative effects of regulating disorder to body asthenic-heat rising such as prickly heat, blain and white hair due to hot and dry weather; the sandy soil in the formula is taken from 1m depth underground, rich in fluorine element, and pollution-free; and particularly the local special geological conditions result in the resources which are rich in the fluorine element.

The invention relates to the technical field of oral disease treatment and prevention, in particular to novel application of non-coding RNA and streptococcus constructed by the non-coding RNA. The invention discloses application of non-coding RNA (Ribonucleic Acid) in preparation of streptococcus mutans with reduced cariogenic ability. The sequence of the non-coding RNA is shown as SEQ ID NO. 1. According to the scheme, the research finds that the expression quantity of non-coding RNA in dental plaque of children without caries is increased, the inventor constructs an ASvicK overexpression strain, confirms that ASvicK can regulate and control vicK gene expression, and finds that ASvicK can change the growth form of streptococcus mutans and interfere exopolysaccharide metabolism and cariogenic property of streptococcus mutans. According to the scheme, the technical problem that a streptococcus mutans mutant strain which has an ideal caries treatment effect and is simple in preparation method is lacked in the prior art is solved, and the obtained strain can be used for adjusting oral flora imbalance, reducing the number of streptococcus mutans with high cariogenic capacity and preventing occurrence and development of caries.

The invention discloses a Chinese medicinal preparation for treating persistent vegetative state (PVS), which comprises the following components in part by weight: 20 to 40 parts of astragalus, 9 to 12 parts of Chinese angelica, 0.05 to 0.1 part of musk, 8 to 12 parts of peach seed, 6 to 12 parts of grassleaf sweelflag rhizome and 9 to 12 parts of dahurian angelica root. The Chinese medicinal preparation for treating the persistent vegetative state (PVS) is vitality invigorating and aperture inducing granules and has the effects of improving the PVS marking of prior-treatment and post-treatment patients, promoting the patients to revive, improving cerebral blood supply and the hypoxia tolerant capacity of cerebral cells, exciting cerebral cortical neurons, adjusting the imbalance of intracerebral neurotransmitter dopamine and amino acid, repairing nerve cells. The pure Chinese medicinal preparation in the formulation of the granules maintains the characteristics of quick absorption and response of decoction, and overcomes the defects that the decoction is inconvenient to decoct when in use, large in dose, easy to mildew and deteriorate and the like.

The invention provides a special clinical nutritional formulation for AIDS (Acquired Immune Deficiency Syndrome). The special clinical nutritional formulation is prepared from the following componentsin parts by weight: 23 to 32 parts of protein, 13 to 17 parts of fat, 27 to 40 parts of carbohydrate, 10 to 20 parts of dietary fiber, 0.4 to 0.7 part of macro elements, 0.01 to 0.04 part of trace elements, 0.005 to 0.02 part of fat soluble vitamin, 0.1 to 0.25 part of water-soluble vitamin, 0.1 to 4 parts of dietary essence, 0.2 to 2 parts of medicinal and edible ingredients and 0.05 to 4 partsof new resource food. The invention also provides a preparation method of the clinical nutritional formulation. The clinical nutritional formulation provided by the invention has the advantages that the toxic and side effects and adverse reactions of anti-AIDS drugs can be alleviated; corresponding symptoms of the AIDS are relieved from the pathogenesis; the autoimmunity barrier of patients is repaired and the occurrence of opportunistic infection is prevented, so that nutritional auxiliary functions of the special clinical nutritional formulation in clinical treatment are realized.

The invention discloses a dendrobium nobile composition as well as a preparation method and application thereof, and belongs to the field of plant compositions. The dendrobium composition is prepared from the following raw materials in parts by weight: 1.0 part of dendrobium officinale, 1.2 to 2.0 parts of radix astragali seu hedysari, 1.0 to 2.5 parts of radix pseudostellariae and 0.2 to 0.6 part of fructus lycii. The invention further discloses a preparation method and application of the dendrobium nobile composition. The dendrobium nobile composition has the effects of reducing blood sugar and blood fat, improving hyperglycemia symptoms and the like.