The invention relates to a cannabidiol rubber plaster with an osteopathy treatment effect, and a production method thereof. The plaster is produced from, by weight, 7.14-7.24 parts of cannabidiol, 62.96-63.5 parts of zinc oxide, 4-5 parts of methyl salicylate, 103.3-103.8 parts of rubber, 111.8-112.8 parts of lithopone, 49.5-50.5 parts of rosin, 11.3-12.3 parts of yellow Vaseline, 4.2-4.5 parts of lanolin and 2.8-3.8 parts of liquid paraffin. The production method comprises the following steps: 1, weighing; 2, rubber swelling; 3, mixing; 4, refining; 5, rubber fermentation; and 6, coating and slicing. The cannabidiol rubber plaster with an osteopathy treatment effect has the advantages of easiness in pasting, convenience in uncovering, convenience in use, small irritation to skins, and good channel regulating, collateral activating and pain relieving effects.